The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice
A combination of buprenorphine/naltrexone treatment had been proven to successfully attenuate relapse (reinstatement) to morphine/methamphetamine (poly-drug) addiction in mice using a conditioned place preference (CPP) model. This treatment combination exhibits a mixed opioid receptor pharmacologica...
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| Format: | Article |
| Language: | English |
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A and V Publication
2017
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| Online Access: | http://irep.iium.edu.my/63442/ http://irep.iium.edu.my/63442/1/63442_The%20crucial%20role%20of%20nociceptin%20opioid%20peptide%20%28NOP%29.pdf |
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| author | Ridzwan, Irna Elina Abdul Rahman, Nor Akhi Hijriyati Wasli, Nur Syafinaz |
| author_facet | Ridzwan, Irna Elina Abdul Rahman, Nor Akhi Hijriyati Wasli, Nur Syafinaz |
| author_sort | Ridzwan, Irna Elina |
| building | IIUM Repository |
| collection | Online Access |
| description | A combination of buprenorphine/naltrexone treatment had been proven to successfully attenuate relapse (reinstatement) to morphine/methamphetamine (poly-drug) addiction in mice using a conditioned place preference (CPP) model. This treatment combination exhibits a mixed opioid receptor pharmacological activities (mu/kappa antagonist and partial NOP agonist). Thus, this recent study aimed to investigate the independent role of the NOP receptor in attenuating relapse to this poly-drug addiction. The male Swiss albino mice were made dependent on 7.5 mg/kg morphine/1.0 mg/kg methamphetamine (poly-drug). The mice were injected with SB 612111 (a selective NOP antagonist) during reinstatement phase, 30 minutes before the administration of0.3 mg/kg buprenorphine/1.0 mg/kg naltrexone combination. The priming dose of poly-drug (2.5 mg/kg morphine/1.0 mg/kg methamphetamine) were given 10 minutes later. The percentage of time spent at the drug-paired compartment was compared with the control group (did not receive SB 612111 treatment). The results revealed that the relapse to poly-drug addiction happened in the group of mice that received SB 612111 prior to buprenorphine/naltrexone (53.81 ± 11.23 %, n = 6). This result was significantly different compared to its own baseline (before the mice were made dependent on poly-drug [-5.37 ± 6.42 %, n = 9, p < 0.05]). In contrast, relapse was significantly attenuated (reduced) in the group of mice that did not receive SB 612111 prior to buprenorphine/naltrexone (19.14 ± 16.89 %, n = 5). The percentage of time spent at the drug-paired compartment was found to be not significantly different compared to its own baseline (-16.14 ± 4.81 %, n = 13). The result suggests that an agonist activity at the NOP receptor is crucial in attenuating relapse to morphine/methamphetamine (poly-drug) addiction. Hence, further investigation needs to be done to evaluate the involvement of this receptor at the brain level. |
| first_indexed | 2025-11-14T17:02:36Z |
| format | Article |
| id | iium-63442 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T17:02:36Z |
| publishDate | 2017 |
| publisher | A and V Publication |
| recordtype | eprints |
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| spelling | iium-634422018-04-26T08:59:20Z http://irep.iium.edu.my/63442/ The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice Ridzwan, Irna Elina Abdul Rahman, Nor Akhi Hijriyati Wasli, Nur Syafinaz RS Pharmacy and materia medica A combination of buprenorphine/naltrexone treatment had been proven to successfully attenuate relapse (reinstatement) to morphine/methamphetamine (poly-drug) addiction in mice using a conditioned place preference (CPP) model. This treatment combination exhibits a mixed opioid receptor pharmacological activities (mu/kappa antagonist and partial NOP agonist). Thus, this recent study aimed to investigate the independent role of the NOP receptor in attenuating relapse to this poly-drug addiction. The male Swiss albino mice were made dependent on 7.5 mg/kg morphine/1.0 mg/kg methamphetamine (poly-drug). The mice were injected with SB 612111 (a selective NOP antagonist) during reinstatement phase, 30 minutes before the administration of0.3 mg/kg buprenorphine/1.0 mg/kg naltrexone combination. The priming dose of poly-drug (2.5 mg/kg morphine/1.0 mg/kg methamphetamine) were given 10 minutes later. The percentage of time spent at the drug-paired compartment was compared with the control group (did not receive SB 612111 treatment). The results revealed that the relapse to poly-drug addiction happened in the group of mice that received SB 612111 prior to buprenorphine/naltrexone (53.81 ± 11.23 %, n = 6). This result was significantly different compared to its own baseline (before the mice were made dependent on poly-drug [-5.37 ± 6.42 %, n = 9, p < 0.05]). In contrast, relapse was significantly attenuated (reduced) in the group of mice that did not receive SB 612111 prior to buprenorphine/naltrexone (19.14 ± 16.89 %, n = 5). The percentage of time spent at the drug-paired compartment was found to be not significantly different compared to its own baseline (-16.14 ± 4.81 %, n = 13). The result suggests that an agonist activity at the NOP receptor is crucial in attenuating relapse to morphine/methamphetamine (poly-drug) addiction. Hence, further investigation needs to be done to evaluate the involvement of this receptor at the brain level. A and V Publication 2017-12-30 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63442/1/63442_The%20crucial%20role%20of%20nociceptin%20opioid%20peptide%20%28NOP%29.pdf Ridzwan, Irna Elina and Abdul Rahman, Nor Akhi Hijriyati and Wasli, Nur Syafinaz (2017) The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice. Research Journal of Pharmacy and Technology, 10 (12). pp. 4488-4550. ISSN 0974-3618 E-ISSN 0974-360X http://rjptonline.org/AbstractView.aspx?PID=2017-10-12-79 |
| spellingShingle | RS Pharmacy and materia medica Ridzwan, Irna Elina Abdul Rahman, Nor Akhi Hijriyati Wasli, Nur Syafinaz The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice |
| title | The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice |
| title_full | The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice |
| title_fullStr | The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice |
| title_full_unstemmed | The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice |
| title_short | The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice |
| title_sort | crucial role of nociceptin opioid peptide (nop) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/63442/ http://irep.iium.edu.my/63442/ http://irep.iium.edu.my/63442/1/63442_The%20crucial%20role%20of%20nociceptin%20opioid%20peptide%20%28NOP%29.pdf |