Model of critical size defect in the New Zealand White rabbit's tibia
Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbits (Oryctolagus cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new bone substitute material. There are varieties of protocols available in the literature....
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English English English |
| Published: |
2018
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/63258/ http://irep.iium.edu.my/63258/1/Vol17-No1-p013018%20-%20Model%20of%20critical%20size%20defect.pdf http://irep.iium.edu.my/63258/7/63258_Model%20of%20critical%20size%20defect%20in%20the%20New%20Zealand%20White_scopus.pdf http://irep.iium.edu.my/63258/13/63258_Model%20of%20critical%20size%20defect%20in%20the%20New%20Zealand%20White_WoS.pdf |
| _version_ | 1848786001966661632 |
|---|---|
| author | Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Sharifudin, Mohd Ariff Che Ahmad, Aminudin Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah |
| author_facet | Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Sharifudin, Mohd Ariff Che Ahmad, Aminudin Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah |
| author_sort | Che Seman, Che Nor Zarida |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbits (Oryctolagus
cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new
bone substitute material. There are varieties of protocols available in the literature. This technical note
attempts to present an alternative surgical technique of a CSD in the New Zealand white rabbit tibia.
Methods: Thirty-nine New Zealand White rabbits were used in this study. A CSD of approximately 4.5 mm
(width) X 9.0 mm (length) was surgically drilled at the proximal tibial metaphysis, approximately 1 cm from
the knee joint. The surrounding of soft tissue was repositioned and sutured layer by layer with bioabsorbable
surgical suture. Two x-rays of anteroposterior and lateral were taken before assessed under computed
tomography scan at 6, 12 and 24 weeks. Results: This alternative method created CSD with less bleeding
from the muscle observed. No mortality or other surgical complications observed within 6 weeks, 12 weeks
and 24 weeks following surgery. Conclusion: A simple and safe method for performing CSD was
demonstrated and recommended as an alternative approach for surgery on New Zealand White rabbits. |
| first_indexed | 2025-11-14T17:02:06Z |
| format | Article |
| id | iium-63258 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:02:06Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-632582018-10-31T06:17:43Z http://irep.iium.edu.my/63258/ Model of critical size defect in the New Zealand White rabbit's tibia Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Sharifudin, Mohd Ariff Che Ahmad, Aminudin Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah R Medicine (General) Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbits (Oryctolagus cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new bone substitute material. There are varieties of protocols available in the literature. This technical note attempts to present an alternative surgical technique of a CSD in the New Zealand white rabbit tibia. Methods: Thirty-nine New Zealand White rabbits were used in this study. A CSD of approximately 4.5 mm (width) X 9.0 mm (length) was surgically drilled at the proximal tibial metaphysis, approximately 1 cm from the knee joint. The surrounding of soft tissue was repositioned and sutured layer by layer with bioabsorbable surgical suture. Two x-rays of anteroposterior and lateral were taken before assessed under computed tomography scan at 6, 12 and 24 weeks. Results: This alternative method created CSD with less bleeding from the muscle observed. No mortality or other surgical complications observed within 6 weeks, 12 weeks and 24 weeks following surgery. Conclusion: A simple and safe method for performing CSD was demonstrated and recommended as an alternative approach for surgery on New Zealand White rabbits. 2018-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63258/1/Vol17-No1-p013018%20-%20Model%20of%20critical%20size%20defect.pdf application/pdf en http://irep.iium.edu.my/63258/7/63258_Model%20of%20critical%20size%20defect%20in%20the%20New%20Zealand%20White_scopus.pdf application/pdf en http://irep.iium.edu.my/63258/13/63258_Model%20of%20critical%20size%20defect%20in%20the%20New%20Zealand%20White_WoS.pdf Che Seman, Che Nor Zarida and Zakaria@Mohamad, Zamzuri and Sharifudin, Mohd Ariff and Che Ahmad, Aminudin and Awang, Mohd Shukrimi and Mohd Yusof, Nazri and Buyong, Zunariah (2018) Model of critical size defect in the New Zealand White rabbit's tibia. The International Medical Journal Malaysia, 17 (1). pp. 13-18. E-ISSN 1823-4631 http://iiumedic.net/imjm/v1/ |
| spellingShingle | R Medicine (General) Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Sharifudin, Mohd Ariff Che Ahmad, Aminudin Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah Model of critical size defect in the New Zealand White rabbit's tibia |
| title | Model of critical size defect in the New Zealand White rabbit's tibia |
| title_full | Model of critical size defect in the New Zealand White rabbit's tibia |
| title_fullStr | Model of critical size defect in the New Zealand White rabbit's tibia |
| title_full_unstemmed | Model of critical size defect in the New Zealand White rabbit's tibia |
| title_short | Model of critical size defect in the New Zealand White rabbit's tibia |
| title_sort | model of critical size defect in the new zealand white rabbit's tibia |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/63258/ http://irep.iium.edu.my/63258/ http://irep.iium.edu.my/63258/1/Vol17-No1-p013018%20-%20Model%20of%20critical%20size%20defect.pdf http://irep.iium.edu.my/63258/7/63258_Model%20of%20critical%20size%20defect%20in%20the%20New%20Zealand%20White_scopus.pdf http://irep.iium.edu.my/63258/13/63258_Model%20of%20critical%20size%20defect%20in%20the%20New%20Zealand%20White_WoS.pdf |