Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced p...
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| Format: | Article |
| Language: | English English |
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King Saud University
2017
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| Online Access: | http://irep.iium.edu.my/62988/ http://irep.iium.edu.my/62988/1/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_article.pdf http://irep.iium.edu.my/62988/2/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_scopus.pdf |
| _version_ | 1848785948273278976 |
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| author | Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud Alasmary, Fatmah A.S. El-Meligy, Reham M. Zain, Mohamed E. Alqasoumi, Saleh Ibrahim |
| author_facet | Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud Alasmary, Fatmah A.S. El-Meligy, Reham M. Zain, Mohamed E. Alqasoumi, Saleh Ibrahim |
| author_sort | Awaad, Amani Shafeek |
| building | IIUM Repository |
| collection | Online Access |
| description | A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced percent protection of control ulcer by 66.7 at dose 100 mg/kg. In addition it showed a potent anti-Helicobacter pylori activity in vitro against 7 clinically isolated strains. The minimum inhibitory concentration (MIC) ranged from 12.5 to 50 μg/ml. The preliminary safety studies and toxicity profile are optimistic and encouraging. |
| first_indexed | 2025-11-14T17:01:15Z |
| format | Article |
| id | iium-62988 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:01:15Z |
| publishDate | 2017 |
| publisher | King Saud University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-629882018-06-21T02:44:29Z http://irep.iium.edu.my/62988/ Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud Alasmary, Fatmah A.S. El-Meligy, Reham M. Zain, Mohamed E. Alqasoumi, Saleh Ibrahim Q Science (General) QD Chemistry A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced percent protection of control ulcer by 66.7 at dose 100 mg/kg. In addition it showed a potent anti-Helicobacter pylori activity in vitro against 7 clinically isolated strains. The minimum inhibitory concentration (MIC) ranged from 12.5 to 50 μg/ml. The preliminary safety studies and toxicity profile are optimistic and encouraging. King Saud University 2017-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/62988/1/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_article.pdf application/pdf en http://irep.iium.edu.my/62988/2/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_scopus.pdf Awaad, Amani Shafeek and Alafeefy, Ahmed Mahmoud and Alasmary, Fatmah A.S. and El-Meligy, Reham M. and Zain, Mohamed E. and Alqasoumi, Saleh Ibrahim (2017) Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity. Saudi Pharmaceutical Journal, 25 (7). pp. 967-971. ISSN 1319-0164 https://ac.els-cdn.com/S1319016417300336/1-s2.0-S1319016417300336-main.pdf?_tid=65296070-a4b4-4070-87ff-74fafe7351e2&acdnat=1521772234_e894eeedbc735db615b2bce506872115 10.1016/j.jsps.2017.02.012 |
| spellingShingle | Q Science (General) QD Chemistry Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud Alasmary, Fatmah A.S. El-Meligy, Reham M. Zain, Mohamed E. Alqasoumi, Saleh Ibrahim Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity |
| title | Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity |
| title_full | Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity |
| title_fullStr | Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity |
| title_full_unstemmed | Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity |
| title_short | Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity |
| title_sort | novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity |
| topic | Q Science (General) QD Chemistry |
| url | http://irep.iium.edu.my/62988/ http://irep.iium.edu.my/62988/ http://irep.iium.edu.my/62988/ http://irep.iium.edu.my/62988/1/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_article.pdf http://irep.iium.edu.my/62988/2/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_scopus.pdf |