Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution
This study aimed to investigate the metastable zone width (MSZW) and the nucleation order of carbamazepine–saccharin (CBZ–SAC) co-crystals via slow cooling crystallisation, to obtain the kinetic value using Kashchiev–Borissova–Hammond–Roberts (KBHR) technique and to deduce the induction time, the ra...
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| Format: | Article |
| Language: | English English English English |
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Springer Netherlands
2017
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| Online Access: | http://irep.iium.edu.my/62951/ http://irep.iium.edu.my/62951/1/62951_Kinetics%20and%20nucleation%20mechanism%20of%20carbamazepine_article.pdf http://irep.iium.edu.my/62951/2/62951_Kinetics%20and%20nucleation%20mechanism%20of%20carbamazepine_scopus.pdf http://irep.iium.edu.my/62951/13/2017_J_Therm_Anal_Calorim_rushdi.pdf http://irep.iium.edu.my/62951/15/s10973-017-6483-1 |
| _version_ | 1848785939763036160 |
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| author | Mohammad, Khairool Azizul Abd Rahim, Syarifah Abu Bakar, Mohd Rushdi |
| author_facet | Mohammad, Khairool Azizul Abd Rahim, Syarifah Abu Bakar, Mohd Rushdi |
| author_sort | Mohammad, Khairool Azizul |
| building | IIUM Repository |
| collection | Online Access |
| description | This study aimed to investigate the metastable zone width (MSZW) and the nucleation order of carbamazepine–saccharin (CBZ–SAC) co-crystals via slow cooling crystallisation, to obtain the kinetic value using Kashchiev–Borissova–Hammond–Roberts (KBHR) technique and to deduce the induction time, the radius of the critical nucleus and the interfacial energy of the CBZ–SAC co-crystals via fast cooling. Slow cooling experiments with cooling/heating rates of 0.8, 0.6, 0.4 and 0.2 °C min−1 were applied to determine the crystallisation and the dissolution temperature of CBZ–SAC co-crystals at SAC:CBZ ratios of (3.5, 3.0, 2.5, 2.0 and 1.0) and CBZ concentrations of 19.14, 17.96, 17.06 and 15.83 mg mL−1. Then, fast cooling experiments were run at CBZ concentration of 17.96 mg mL−1 and SAC:CBZ mole ratio of 2.0. Nucleation kinetics, such as MSZW, nucleation order, nucleation kinetic constant and interfacial energy, was determined and analysed. KBHR method was applied to analyse the kinetics value and compared with isothermal method. The nucleation orders obtained from slow cooling method were in between 1.65 and 4.9, which were within the range for nucleation of organic compounds. The results of KBHR method in determining the kinetic values of CBZ–SAC co-crystals were similar to those of the isothermal method. |
| first_indexed | 2025-11-14T17:01:07Z |
| format | Article |
| id | iium-62951 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English English |
| last_indexed | 2025-11-14T17:01:07Z |
| publishDate | 2017 |
| publisher | Springer Netherlands |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-629512019-07-15T01:59:15Z http://irep.iium.edu.my/62951/ Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution Mohammad, Khairool Azizul Abd Rahim, Syarifah Abu Bakar, Mohd Rushdi TP155 Chemical engineering This study aimed to investigate the metastable zone width (MSZW) and the nucleation order of carbamazepine–saccharin (CBZ–SAC) co-crystals via slow cooling crystallisation, to obtain the kinetic value using Kashchiev–Borissova–Hammond–Roberts (KBHR) technique and to deduce the induction time, the radius of the critical nucleus and the interfacial energy of the CBZ–SAC co-crystals via fast cooling. Slow cooling experiments with cooling/heating rates of 0.8, 0.6, 0.4 and 0.2 °C min−1 were applied to determine the crystallisation and the dissolution temperature of CBZ–SAC co-crystals at SAC:CBZ ratios of (3.5, 3.0, 2.5, 2.0 and 1.0) and CBZ concentrations of 19.14, 17.96, 17.06 and 15.83 mg mL−1. Then, fast cooling experiments were run at CBZ concentration of 17.96 mg mL−1 and SAC:CBZ mole ratio of 2.0. Nucleation kinetics, such as MSZW, nucleation order, nucleation kinetic constant and interfacial energy, was determined and analysed. KBHR method was applied to analyse the kinetics value and compared with isothermal method. The nucleation orders obtained from slow cooling method were in between 1.65 and 4.9, which were within the range for nucleation of organic compounds. The results of KBHR method in determining the kinetic values of CBZ–SAC co-crystals were similar to those of the isothermal method. Springer Netherlands 2017-12-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/62951/1/62951_Kinetics%20and%20nucleation%20mechanism%20of%20carbamazepine_article.pdf application/pdf en http://irep.iium.edu.my/62951/2/62951_Kinetics%20and%20nucleation%20mechanism%20of%20carbamazepine_scopus.pdf application/pdf en http://irep.iium.edu.my/62951/13/2017_J_Therm_Anal_Calorim_rushdi.pdf application/pdf en http://irep.iium.edu.my/62951/15/s10973-017-6483-1 Mohammad, Khairool Azizul and Abd Rahim, Syarifah and Abu Bakar, Mohd Rushdi (2017) Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution. Journal of Thermal Analysis and Calorimetry, 130 (3). pp. 1663-1669. ISSN 1388-6150 E-ISSN 1588-2926 https://link.springer.com/article/10.1007/s10973-017-6483-1 10.1007/s10973-017-6483-1 |
| spellingShingle | TP155 Chemical engineering Mohammad, Khairool Azizul Abd Rahim, Syarifah Abu Bakar, Mohd Rushdi Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution |
| title | Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution |
| title_full | Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution |
| title_fullStr | Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution |
| title_full_unstemmed | Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution |
| title_short | Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution |
| title_sort | kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution |
| topic | TP155 Chemical engineering |
| url | http://irep.iium.edu.my/62951/ http://irep.iium.edu.my/62951/ http://irep.iium.edu.my/62951/ http://irep.iium.edu.my/62951/1/62951_Kinetics%20and%20nucleation%20mechanism%20of%20carbamazepine_article.pdf http://irep.iium.edu.my/62951/2/62951_Kinetics%20and%20nucleation%20mechanism%20of%20carbamazepine_scopus.pdf http://irep.iium.edu.my/62951/13/2017_J_Therm_Anal_Calorim_rushdi.pdf http://irep.iium.edu.my/62951/15/s10973-017-6483-1 |