A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines
Researches in compound containing sulphur and the polyamine transport system is beneficial in oncology as both affect cancer cells. Compounds containing sulphur such as organosulphur are known for its anti-cancer properties. Through various experiments by researcher, several new compounds were succe...
| Main Authors: | , , , , |
|---|---|
| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
2017
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/62787/ http://irep.iium.edu.my/62787/1/Scan%2027%20Nov%202017%2C%2012.10.pdf http://irep.iium.edu.my/62787/2/UPM%20poster.pdf |
| _version_ | 1848785906753863680 |
|---|---|
| author | Sahabudin, Adzly Hairee Abdul Ghani, Radiah How, Fiona Ni Foong Halim, Norsuhana Jamil, Masnizahani |
| author_facet | Sahabudin, Adzly Hairee Abdul Ghani, Radiah How, Fiona Ni Foong Halim, Norsuhana Jamil, Masnizahani |
| author_sort | Sahabudin, Adzly Hairee |
| building | IIUM Repository |
| collection | Online Access |
| description | Researches in compound containing sulphur and the polyamine transport system is beneficial in oncology as both affect cancer cells. Compounds containing sulphur such as organosulphur are known for its anti-cancer properties. Through various experiments by researcher, several new compounds were successfully synthesized to combat cancer cells. Some of the compounds that were successfully synthesized were the polyamine-sulphur compounds. By adding sulphur to known natural polyamine, the analogues will be delivered specifically to cancer cells via polyamine transport system (PTS). For the synthesis of the compound, carbon disulphide and benzyl chloride were added to the polyamine (Putrescine or Spermidine) via a method called Room Temperature Mediated Synthesis. The addition of carbon disulphide was to add the sulphur element while the addition of benzyl chloride was to make the compound bulkier and stable. For the addition of carbon disulphide only, the compounds were named PSA-1 and SSA-1 for putrescine and spermidine respectively while for the addition of both carbon disulphide and benzyl chloride were named PSA-2 and SSA-2. The compounds were then analyzed by using Fourier Transformed Infrared Spectroscopy (FTIR) and Gas Chromatography-Mass Spectroscopy (GC-MS) to determine the successful addition of sulphur and benzyl compound. The compounds were then tested with human lung adenocarcinoma cells (A549), human breast adenocarcinoma cell (MCF-7) and human colorectal adenocarcinoma cells (HCT-8). The cytotoxicity effects of these compounds were carried by using MTT assay against these in-vitro cells. The results show the cytotoxic effects were not potent against these cell lines as a higher concentration of compounds were needed to inhibit the cells growth. |
| first_indexed | 2025-11-14T17:00:35Z |
| format | Proceeding Paper |
| id | iium-62787 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:00:35Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-627872018-04-06T04:08:13Z http://irep.iium.edu.my/62787/ A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines Sahabudin, Adzly Hairee Abdul Ghani, Radiah How, Fiona Ni Foong Halim, Norsuhana Jamil, Masnizahani RM300 Drugs and their action Researches in compound containing sulphur and the polyamine transport system is beneficial in oncology as both affect cancer cells. Compounds containing sulphur such as organosulphur are known for its anti-cancer properties. Through various experiments by researcher, several new compounds were successfully synthesized to combat cancer cells. Some of the compounds that were successfully synthesized were the polyamine-sulphur compounds. By adding sulphur to known natural polyamine, the analogues will be delivered specifically to cancer cells via polyamine transport system (PTS). For the synthesis of the compound, carbon disulphide and benzyl chloride were added to the polyamine (Putrescine or Spermidine) via a method called Room Temperature Mediated Synthesis. The addition of carbon disulphide was to add the sulphur element while the addition of benzyl chloride was to make the compound bulkier and stable. For the addition of carbon disulphide only, the compounds were named PSA-1 and SSA-1 for putrescine and spermidine respectively while for the addition of both carbon disulphide and benzyl chloride were named PSA-2 and SSA-2. The compounds were then analyzed by using Fourier Transformed Infrared Spectroscopy (FTIR) and Gas Chromatography-Mass Spectroscopy (GC-MS) to determine the successful addition of sulphur and benzyl compound. The compounds were then tested with human lung adenocarcinoma cells (A549), human breast adenocarcinoma cell (MCF-7) and human colorectal adenocarcinoma cells (HCT-8). The cytotoxicity effects of these compounds were carried by using MTT assay against these in-vitro cells. The results show the cytotoxic effects were not potent against these cell lines as a higher concentration of compounds were needed to inhibit the cells growth. 2017-11 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/62787/1/Scan%2027%20Nov%202017%2C%2012.10.pdf application/pdf en http://irep.iium.edu.my/62787/2/UPM%20poster.pdf Sahabudin, Adzly Hairee and Abdul Ghani, Radiah and How, Fiona Ni Foong and Halim, Norsuhana and Jamil, Masnizahani (2017) A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines. In: Fundamental Science Congress 2017 (FSC 2017), 21st-22nd Nov. 2017, Serdang, Selangor. (Unpublished) http://www.upm.edu.my/activities/fundamental_science_congress_2017_fsc_2017-11199 |
| spellingShingle | RM300 Drugs and their action Sahabudin, Adzly Hairee Abdul Ghani, Radiah How, Fiona Ni Foong Halim, Norsuhana Jamil, Masnizahani A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines |
| title | A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines |
| title_full | A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines |
| title_fullStr | A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines |
| title_full_unstemmed | A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines |
| title_short | A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines |
| title_sort | review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines |
| topic | RM300 Drugs and their action |
| url | http://irep.iium.edu.my/62787/ http://irep.iium.edu.my/62787/ http://irep.iium.edu.my/62787/1/Scan%2027%20Nov%202017%2C%2012.10.pdf http://irep.iium.edu.my/62787/2/UPM%20poster.pdf |