Effects of solvents on polymorphism and shape of mefenamic acid crystals
Mefenamic acid [2-(2, 3-dimethylphenyl) amino benzoic acid] is an active pharmaceutical compound that exist in different polymorphic form and shape. In this work the effect of solvents on polymorphism and shape of mefenamic acid crystals were examined. The solvents used were ethanol, isopropanol, et...
| Main Authors: | , , , , , , , |
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| Format: | Proceeding Paper |
| Language: | English English |
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EDP Sciences
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/62633/ http://irep.iium.edu.my/62633/13/62633%20Effects%20of%20Solvents%20on%20Polymorphism%20and%20Shape.pdf http://irep.iium.edu.my/62633/19/62633_Effects%20of%20solvents%20on%20polymorphism%20and%20shape_scopus_new.pdf |
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| author | Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Jamal, Parveen Adam, Fatmawati Che Man, Rohaida Sulaiman, Siti Zubaidah Mohd Arshad, Zatul Iffah Md. Shaarani, Shalyda |
| author_facet | Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Jamal, Parveen Adam, Fatmawati Che Man, Rohaida Sulaiman, Siti Zubaidah Mohd Arshad, Zatul Iffah Md. Shaarani, Shalyda |
| author_sort | Abdul Mudalip, Siti Kholijah |
| building | IIUM Repository |
| collection | Online Access |
| description | Mefenamic acid [2-(2, 3-dimethylphenyl) amino benzoic acid] is an active pharmaceutical compound that exist in different polymorphic form and shape. In this work the effect of solvents on polymorphism and shape of mefenamic acid crystals were examined. The solvents used were ethanol, isopropanol, ethyl acetate, dimethyl acetamide, dimethyl formamide, and acetone. Natural cooling was employed during the crystallisation process. The crystals produced were dried and analysed using optical microscopy, differential scanning calorimetry, thermal gravimetric analysis, x-ray powder diffraction (XRPD) and fourier transform infrared spectroscopy (FTIR). The analysis confirmed that the crystals obtained using ethyl acetate, ethanol, isopropanol, and acetone are pure Form I with a needle-like flat shape. Meanwhile, the crystallisation using DMF produced polymorphic Form II in cubic shape. |
| first_indexed | 2025-11-14T17:00:07Z |
| format | Proceeding Paper |
| id | iium-62633 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:00:07Z |
| publishDate | 2018 |
| publisher | EDP Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-626332018-07-10T09:03:37Z http://irep.iium.edu.my/62633/ Effects of solvents on polymorphism and shape of mefenamic acid crystals Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Jamal, Parveen Adam, Fatmawati Che Man, Rohaida Sulaiman, Siti Zubaidah Mohd Arshad, Zatul Iffah Md. Shaarani, Shalyda T Technology (General) T175 Industrial research. Research and development Mefenamic acid [2-(2, 3-dimethylphenyl) amino benzoic acid] is an active pharmaceutical compound that exist in different polymorphic form and shape. In this work the effect of solvents on polymorphism and shape of mefenamic acid crystals were examined. The solvents used were ethanol, isopropanol, ethyl acetate, dimethyl acetamide, dimethyl formamide, and acetone. Natural cooling was employed during the crystallisation process. The crystals produced were dried and analysed using optical microscopy, differential scanning calorimetry, thermal gravimetric analysis, x-ray powder diffraction (XRPD) and fourier transform infrared spectroscopy (FTIR). The analysis confirmed that the crystals obtained using ethyl acetate, ethanol, isopropanol, and acetone are pure Form I with a needle-like flat shape. Meanwhile, the crystallisation using DMF produced polymorphic Form II in cubic shape. EDP Sciences 2018 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/62633/13/62633%20Effects%20of%20Solvents%20on%20Polymorphism%20and%20Shape.pdf application/pdf en http://irep.iium.edu.my/62633/19/62633_Effects%20of%20solvents%20on%20polymorphism%20and%20shape_scopus_new.pdf Abdul Mudalip, Siti Kholijah and Abu Bakar, Mohd Rushdi and Jamal, Parveen and Adam, Fatmawati and Che Man, Rohaida and Sulaiman, Siti Zubaidah and Mohd Arshad, Zatul Iffah and Md. Shaarani, Shalyda (2018) Effects of solvents on polymorphism and shape of mefenamic acid crystals. In: Malaysia Technical Universities Conference on Engineering and Technology (MUCET 2017)., 6-7 Dec,2017, Penang. https://www.matec-conferences.org/articles/matecconf/pdf/2018/09/matecconf_mucet2018_02004.pdf 10.1051/matecconf/201815002004 |
| spellingShingle | T Technology (General) T175 Industrial research. Research and development Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Jamal, Parveen Adam, Fatmawati Che Man, Rohaida Sulaiman, Siti Zubaidah Mohd Arshad, Zatul Iffah Md. Shaarani, Shalyda Effects of solvents on polymorphism and shape of mefenamic acid crystals |
| title | Effects of solvents on polymorphism and shape of mefenamic acid crystals |
| title_full | Effects of solvents on polymorphism and shape of mefenamic acid crystals |
| title_fullStr | Effects of solvents on polymorphism and shape of mefenamic acid crystals |
| title_full_unstemmed | Effects of solvents on polymorphism and shape of mefenamic acid crystals |
| title_short | Effects of solvents on polymorphism and shape of mefenamic acid crystals |
| title_sort | effects of solvents on polymorphism and shape of mefenamic acid crystals |
| topic | T Technology (General) T175 Industrial research. Research and development |
| url | http://irep.iium.edu.my/62633/ http://irep.iium.edu.my/62633/ http://irep.iium.edu.my/62633/ http://irep.iium.edu.my/62633/13/62633%20Effects%20of%20Solvents%20on%20Polymorphism%20and%20Shape.pdf http://irep.iium.edu.my/62633/19/62633_Effects%20of%20solvents%20on%20polymorphism%20and%20shape_scopus_new.pdf |