A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity
The bioactivity guided fractionation of Tetracera indica leaves crude ethanolic extract has afforded the isolation and characterization of six compounds including a new natural product viz., 5,7-dihydroxyflavone-O-8-sulphate (1) and five known flavonoids (2–6). The structures of the compounds were e...
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| Format: | Article |
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Taylor and Francis
2019
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| Online Access: | http://irep.iium.edu.my/62515/ http://irep.iium.edu.my/62515/9/62515%20A%20new%20sulphated%20flavone_Alhassan%20and%20Qamar%20Uddin%20Ahmed.pdf http://irep.iium.edu.my/62515/20/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_MYRA.pdf http://irep.iium.edu.my/62515/21/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_SCOPUS.pdf http://irep.iium.edu.my/62515/22/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_WOS.pdf |
| _version_ | 1848785856454721536 |
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| author | Alhassan, Alhassan Muhammad Ahmed, Qamar Uddin Latip, Jalifah Shah, Syed Adnan Ali |
| author_facet | Alhassan, Alhassan Muhammad Ahmed, Qamar Uddin Latip, Jalifah Shah, Syed Adnan Ali |
| author_sort | Alhassan, Alhassan Muhammad |
| building | IIUM Repository |
| collection | Online Access |
| description | The bioactivity guided fractionation of Tetracera indica leaves crude ethanolic extract has afforded the isolation and characterization of six compounds including a new natural product viz., 5,7-dihydroxyflavone-O-8-sulphate (1) and five known flavonoids (2–6). The structures of the compounds were elucidated using 1D and 2D NMR and HRESIMS spectroscopic analyses. All the isolated compounds were evaluated for their in vitro inhibitory activity against alpha-glucosidase. Compound 1, 5 and 6 showed strong alpha-glucosidase inhibitory activity, 3 and 4 displayed weak activity while compound 2 was inactive. The interactions of the active compounds with alpha-glucosidase were further investigated using molecular docking to confirm their antidiabetic potential. |
| first_indexed | 2025-11-14T16:59:47Z |
| format | Article |
| id | iium-62515 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English English |
| last_indexed | 2025-11-14T16:59:47Z |
| publishDate | 2019 |
| publisher | Taylor and Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-625152019-06-14T08:23:39Z http://irep.iium.edu.my/62515/ A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity Alhassan, Alhassan Muhammad Ahmed, Qamar Uddin Latip, Jalifah Shah, Syed Adnan Ali QE Geology The bioactivity guided fractionation of Tetracera indica leaves crude ethanolic extract has afforded the isolation and characterization of six compounds including a new natural product viz., 5,7-dihydroxyflavone-O-8-sulphate (1) and five known flavonoids (2–6). The structures of the compounds were elucidated using 1D and 2D NMR and HRESIMS spectroscopic analyses. All the isolated compounds were evaluated for their in vitro inhibitory activity against alpha-glucosidase. Compound 1, 5 and 6 showed strong alpha-glucosidase inhibitory activity, 3 and 4 displayed weak activity while compound 2 was inactive. The interactions of the active compounds with alpha-glucosidase were further investigated using molecular docking to confirm their antidiabetic potential. Taylor and Francis 2019-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/62515/9/62515%20A%20new%20sulphated%20flavone_Alhassan%20and%20Qamar%20Uddin%20Ahmed.pdf application/pdf en http://irep.iium.edu.my/62515/20/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_MYRA.pdf application/pdf en http://irep.iium.edu.my/62515/21/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/62515/22/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_WOS.pdf Alhassan, Alhassan Muhammad and Ahmed, Qamar Uddin and Latip, Jalifah and Shah, Syed Adnan Ali (2019) A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity. Natural Product Research, 33 (1). pp. 1-8. ISSN 1478-6427 (In Press) https://www.tandfonline.com/doi/abs/10.1080/14786419.2018.1437427?journalCode=gnpl20 10.1080/14786419.2018.1437427 |
| spellingShingle | QE Geology Alhassan, Alhassan Muhammad Ahmed, Qamar Uddin Latip, Jalifah Shah, Syed Adnan Ali A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity |
| title | A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity |
| title_full | A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity |
| title_fullStr | A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity |
| title_full_unstemmed | A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity |
| title_short | A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity |
| title_sort | new sulphated flavone and other phytoconstituents from the leaves of tetracera indica merr. and their alpha-glucosidase inhibitory activity |
| topic | QE Geology |
| url | http://irep.iium.edu.my/62515/ http://irep.iium.edu.my/62515/ http://irep.iium.edu.my/62515/ http://irep.iium.edu.my/62515/9/62515%20A%20new%20sulphated%20flavone_Alhassan%20and%20Qamar%20Uddin%20Ahmed.pdf http://irep.iium.edu.my/62515/20/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_MYRA.pdf http://irep.iium.edu.my/62515/21/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_SCOPUS.pdf http://irep.iium.edu.my/62515/22/62515_A%20new%20sulphated%20flavone%20and%20other%20phytoconstituents_WOS.pdf |