Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation
Gliclazide tablet is widely used for the treatment of non-insulin-dependent diabetes mellitus. However, there is still lack of study done in formulating the sustained release gliclazide tablet. Combination of xanthan gum, a natural gum and hydroxypropyl methylcellulose (HPMC) were used to act as ret...
| Main Authors: | , , , |
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/62416/ http://irep.iium.edu.my/62416/1/Cover%20and%20abstract%20_IMFSC%202017.pdf |
| _version_ | 1848785839764537344 |
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| author | Othman, Liyana Zafirah Mohd Nawi, Mohamed Sufian Abul Bashar Mohammed, Helaluddin Elsayed, Tarek Mohamed Ali |
| author_facet | Othman, Liyana Zafirah Mohd Nawi, Mohamed Sufian Abul Bashar Mohammed, Helaluddin Elsayed, Tarek Mohamed Ali |
| author_sort | Othman, Liyana Zafirah |
| building | IIUM Repository |
| collection | Online Access |
| description | Gliclazide tablet is widely used for the treatment of non-insulin-dependent diabetes mellitus. However, there is still lack of study done in formulating the sustained release gliclazide tablet. Combination of xanthan gum, a natural gum and hydroxypropyl methylcellulose (HPMC) were used to act as retardants for the sustained release gliclazide tablet. In this study, sustained release 60 mg gliclazide tablets were formulated with different ratios and content of xanthan gum and HPMC. The tablets were produced by wet granulation and semi-automatic tableting process. The content variation, weight variation, hardness, and friability of the tablet met the specification by British Pharmacopoeia. In vitro dissolution profiles of the tablets were compared with the commercially available sustained release 60 mg gliclazide tablet.
Keywords: Gliclazide; sustained release; xanthan gum; HPMC |
| first_indexed | 2025-11-14T16:59:31Z |
| format | Proceeding Paper |
| id | iium-62416 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:59:31Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-624162018-03-29T01:43:23Z http://irep.iium.edu.my/62416/ Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation Othman, Liyana Zafirah Mohd Nawi, Mohamed Sufian Abul Bashar Mohammed, Helaluddin Elsayed, Tarek Mohamed Ali RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Gliclazide tablet is widely used for the treatment of non-insulin-dependent diabetes mellitus. However, there is still lack of study done in formulating the sustained release gliclazide tablet. Combination of xanthan gum, a natural gum and hydroxypropyl methylcellulose (HPMC) were used to act as retardants for the sustained release gliclazide tablet. In this study, sustained release 60 mg gliclazide tablets were formulated with different ratios and content of xanthan gum and HPMC. The tablets were produced by wet granulation and semi-automatic tableting process. The content variation, weight variation, hardness, and friability of the tablet met the specification by British Pharmacopoeia. In vitro dissolution profiles of the tablets were compared with the commercially available sustained release 60 mg gliclazide tablet. Keywords: Gliclazide; sustained release; xanthan gum; HPMC 2017 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/62416/1/Cover%20and%20abstract%20_IMFSC%202017.pdf Othman, Liyana Zafirah and Mohd Nawi, Mohamed Sufian and Abul Bashar Mohammed, Helaluddin and Elsayed, Tarek Mohamed Ali (2017) Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation. In: International Malaysian French Scientific Conference 2017, 18th-19th December 2017, Kuala Lumpur. (Unpublished) |
| spellingShingle | RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Othman, Liyana Zafirah Mohd Nawi, Mohamed Sufian Abul Bashar Mohammed, Helaluddin Elsayed, Tarek Mohamed Ali Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation |
| title | Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation |
| title_full | Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation |
| title_fullStr | Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation |
| title_full_unstemmed | Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation |
| title_short | Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation |
| title_sort | combination of xanthan gum and hpmc as retardants in sustained release gliclazide formulation |
| topic | RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry |
| url | http://irep.iium.edu.my/62416/ http://irep.iium.edu.my/62416/1/Cover%20and%20abstract%20_IMFSC%202017.pdf |