LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparin, and is a negative modulator of elastinogenesis

QR Code

LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparin, and is a negative modulator of elastinogenesis

Latent transforming growth factor-beta-1 binding protein-2 (LTBP-2) is a protein of ill-defined function associated with elastic fibers during elastinogenesis. Although LTBP-2 binds fibrillin-1, fibulin-5, and heparin/heparan sulfate, molecules critical for normal elastic fiber assembly, it does not...

Full description

Bibliographic Details
Main Authors:	Mohamed Sideek, Mohamed Arshad, Menz, Clementine, Parsi, Mahroo K., Gibson, Mark A.
Format:	Article
Language:	English
Published:	Elsevier B.V 2013
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/62192/ http://irep.iium.edu.my/62192/1/LTBP-2%20Elastin%20paper%20-%20Matrix%20Biology.pdf

Similar Items

LTBP-2 has a single high-affinity binding site for FGF-2 and blocks FGF-2-induced cell proliferation.
by: Menz, Clementine, et al.
Published: (2015)

Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar
by: Mohamed Sideek, Mohamed Arshad, et al.
Published: (2016)

A central bioactive region of LTBP-2 stimulates the expression of TGF-β1 in fibroblasts via akt and p38 signalling pathways
by: Sideek, Mohamed Arshad, et al.
Published: (2017)

Influence of Heparin and Seminal Heparin Binding Proteins on Reproductive Performance of Sahiwalfriesian Bulls and Rabbits
by: Patchaiappan, Ramakrishnan
Published: (2003)

Prediction of heparin binding sites in bone morphogenetic proteins (BMPs)
by: Gandhi, Neha, et al.
Published: (2012)

Heparin mimetics
by: Coombe, Deidre, et al.
Published: (2012)

Heparin mimetics: Their therapeutic potential
by: Mohamed, Shifaza, et al.
Published: (2017)

The glycoprotein fibulin-3 regulates morphology and motility of olfactory ensheathing cells in vitro
by: Vukovic, J., et al.
Published: (2009)

Relationship between bull fertility and binding of 3H heparin to spermatozoa in Sahiwal-Friesian bull
by: Patchaiappan, Ramakrishnan, et al.
Published: (2006)

Heparin for assisted reproduction (Review)
by: Akhtar, Muhammad A., et al.
Published: (2013)

Heparin/heparan sulphate-based drugs
by: Gandhi, Neha, et al.
Published: (2010)

The expression of peroxisome proliferator-activated receptor (ppar1 and ppar2) in naive and memory cd4+ t lymphocytes
by: Mohamed, Rafeezul
Published: (2006)

Characterization of coenzyme binding and selectivity determinants in Mycobacterium tuberculosis flavoprotein reductase A: analysis of Arg199 and Arg200 mutants at the NADP(H) 2'-phosphate binding site
by: Sabri, M.
Published: (2009)

Computational analyses of the catalytic and heparin binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-D-glucuronidase (heparanase)
by: Gandhi, Neha, et al.
Published: (2012)

Effect of different parameters on the pDNA-loaded microspheres prepared by double emulsion solvent evaporation method
by: Doolaanea, Abd. Almonem, et al.
Published: (2010)

Duration of subcutaneous heparin injections : effect on bruising and pain.
by: Chan, Harriet S. C.
Published: (2000)

Heparin mimetics block the activity of interleukins involved in asthma
by: Kett, Warren, et al.
Published: (2007)

Synthesis of heparin conjugated silica nanoparticles for nanomedicine applications
by: Jaradat, Abdolelah
Published: (2020)

The relation between retinoids and non-alcoholic fatty liver: a review
by: Buyong, Zunariah, et al.
Published: (2019)

Amnesia and its relation with concession (Rukhsah) on performing prayer (Solah)
by: Ariaff, Muhammad Ammar Adli, et al.
Published: (2018)

Effects of serum stored at various temperature and freeze-thaw cycles on selected biochemical parameters
by: Abdullah, Nor Zamzila, et al.
Published: (2016)

Paraoxonase-1 (PON1) activity in serum and various anticoagulated-plasma
by: Abdullah, Nor Zamzila, et al.
Published: (2012)

Paraoxonase-1 (PON1): bridging the organophosphate exposure to atherosclerosis
by: Abdullah, Nor Zamzila, et al.
Published: (2014)

Atherosclerosis in chronic organic arsenic (monosodium methylarsonate) exposure
by: Abdullah, Nor Zamzila, et al.
Published: (2015)

Chronic Monosodium Methylarsonate (MSMA) exposure induces oxidation of Low Density Lipoprotein (LDL) and early atherosclerosis development
by: Adekunle, Ishola Afeez, et al.
Published: (2015)

Beyond anticoagulant: heparin as a potential anti-cancer agent
by: Lokwani, Ravi, et al.
Published: (2014)

Beyond anticoagulant : Heparin as a potential anti-cancer agent
by: Ravi, Lokwani, et al.
Published: (2014)

Flash chronopotentiometric sensing of the polyions protamine and heparin at ion-selective membranes
by: Gemene, K., et al.
Published: (2009)

Knowledge and practice of galactogogues consumption among breastfeeding mothers in Pahang
by: Abdul Ghani, Radiah, et al.
Published: (2014)

Chemopreventive effect of Punica granatum in human lung carcinoma A549 cells
by: Nik Abdul Malek, Nik Nurasyikin, et al.
Published: (2014)

Potential hypocholesterolemic and health benefitsof Baccaurea angulata fruit in hypercholesterolemic rabbits
by: Ahmed, Idris Adewale, et al.
Published: (2014)

Antiatherosclerotic effect of Baccaurea angulate: an under-utilized fruit
by: Mikail, Maryam Abimbola, et al.
Published: (2014)

Long-term consumption effect of eurycoma longifolia jack on histopathological changes in the vital organs in rats
by: Alfaqeh, Hamoud Hussein Mohammed
Published: (2014)

Proteins are potent biomarkers to detect colon cancer progression
by: Kuppusamy, Palaniselvam, et al.
Published: (2017)

Changes in leptin and testosterone hormones associated with Eurycoma Longifolia jack (Tongkat ali) root extract consumption in male rats
by: Faisal, Ghasak Ghazi, et al.
Published: (2015)

Antileukemogenesis of nypa fruticans on acute lymphoblastic leukemia – a preliminary study in vitro
by: Mamat, Suhana, et al.
Published: (2015)

Ornithine decarboxylase gene expression in human lung carcinoma cells, A549 treated with pomegranate juice
by: Abdul Ghani, Radiah, et al.
Published: (2015)

Antiproliferative activity of selected prophetic medicinal plants on human lung adenocarcinoma cells, A549
by: Abdul Ghani, Radiah, et al.
Published: (2015)

Renal impairment in intermittent chronic low dose organophosphate exposure: biochemical evidence
by: Aung, Sanda, et al.
Published: (2015)

The anti-cancer effect of Ant-44 (Spermidine-Anthracene Conjugate) via Ornithine decarboxylase activity in K562 cells
by: Abdul Ghani, Radiah, et al.
Published: (2015)