Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2

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Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2

Transforming Growth Factor (TGF) β is a pleiotropic growth factor implicated in the development of atherosclerosis for its role in mediating glycosaminoglycan (GAG) chain hyperelongation on the proteoglycan biglycan, a phenomenon that leads to increased binding of atherogenic lipoproteins in the wal...

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Bibliographic Details
Main Authors:	Rostam, Muhamad Ashraf, Shajimoon, Aravindra, Kamato, Danielle, Mitra, Partha, Piva, Terence J., Cao, Yingnan, Zheng, Wenhua, Osman, Narin, Little, Peter J.
Format:	Article
Language:	English English
Published:	American Society for Pharmacology and Experimental Therapeutics 2018
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/62174/ http://irep.iium.edu.my/62174/7/62174_Flavopiridol%20Inhibits%20TGF-%CE%B2-Stimulated%20Biglycan_article.pdf http://irep.iium.edu.my/62174/8/62174_Flavopiridol%20Inhibits%20TGF-%CE%B2-Stimulated%20Biglycan_scopus.pdf

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