Sepsis mortality score for the prediction of mortality in septic patients
Purpose: To derive a prediction equation for 30-day mortality in sepsis using a multi-marker approach and compare its performance to the Sequential Organ Failure Assessment (SOFA) score. Methods: This study included 159 septic patients admitted to an intensive care unit. Leukocytes count, procalcit...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English English English |
| Published: |
Elsevier BV
2018
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/61635/ http://irep.iium.edu.my/61635/7/61635_Sepsis%20mortality%20score%20for%20the%20prediction%20_scopus.pdf http://irep.iium.edu.my/61635/13/61635_Sepsis%20mortality%20score%20for%20the%20prediction.pdf http://irep.iium.edu.my/61635/14/61635_Sepsis%20mortality%20score%20for%20the%20prediction_WOS.pdf |
| _version_ | 1848785702979895296 |
|---|---|
| author | Wan Mohd Shukeri, Wan Fadzlina Md Ralib, Azrina Abdullah, Norzamzila Mat Nor, Mohd Basri |
| author_facet | Wan Mohd Shukeri, Wan Fadzlina Md Ralib, Azrina Abdullah, Norzamzila Mat Nor, Mohd Basri |
| author_sort | Wan Mohd Shukeri, Wan Fadzlina |
| building | IIUM Repository |
| collection | Online Access |
| description | Purpose: To derive a prediction equation for 30-day mortality in sepsis using a multi-marker approach and compare its performance to the Sequential Organ Failure Assessment (SOFA) score.
Methods: This study included 159 septic patients admitted to an intensive care unit. Leukocytes count, procalcitonin (PCT), interleukin-6 (IL-6), and paraoxonase (PON) and arylesterase (ARE) activities of PON-1 were assayed from blood obtained on ICU presentation. Logistic regression was used to derive sepsis mortality score (SMS), a prediction equation describing the relationship between biomarkers and 30-day mortality.
Results: The 30-day mortality rate was 28.9%. The SMS was [еlogit(p)/(1 + еlogit(p))] × 100; logit(p) =0.74+ (0.004 × PCT)+(0.001 × IL-6)−(0.025 × ARE)−(0.059 × leukocytes count). The SMC had higher area under the receiver operating characteristic curve (95% Cl) than SOFA score [0.814 (0.736–0.892) vs. 0.767 (0.677–0.857)], but is not statistically significant.When the SMSwas added to the SOFA score, prediction of 30-day mortality improved compared to SOFA score used alone [0.845 (0.777–0.899), p=0.022].
Conclusions: A sepsismortality score using baseline leukocytes count, PCT, IL-6 and ARE was derived, which predicted 30-day mortality with very good performance and added significant prognostic information to SOFA score. |
| first_indexed | 2025-11-14T16:57:21Z |
| format | Article |
| id | iium-61635 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T16:57:21Z |
| publishDate | 2018 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-616352018-04-26T07:17:50Z http://irep.iium.edu.my/61635/ Sepsis mortality score for the prediction of mortality in septic patients Wan Mohd Shukeri, Wan Fadzlina Md Ralib, Azrina Abdullah, Norzamzila Mat Nor, Mohd Basri R Medicine (General) Purpose: To derive a prediction equation for 30-day mortality in sepsis using a multi-marker approach and compare its performance to the Sequential Organ Failure Assessment (SOFA) score. Methods: This study included 159 septic patients admitted to an intensive care unit. Leukocytes count, procalcitonin (PCT), interleukin-6 (IL-6), and paraoxonase (PON) and arylesterase (ARE) activities of PON-1 were assayed from blood obtained on ICU presentation. Logistic regression was used to derive sepsis mortality score (SMS), a prediction equation describing the relationship between biomarkers and 30-day mortality. Results: The 30-day mortality rate was 28.9%. The SMS was [еlogit(p)/(1 + еlogit(p))] × 100; logit(p) =0.74+ (0.004 × PCT)+(0.001 × IL-6)−(0.025 × ARE)−(0.059 × leukocytes count). The SMC had higher area under the receiver operating characteristic curve (95% Cl) than SOFA score [0.814 (0.736–0.892) vs. 0.767 (0.677–0.857)], but is not statistically significant.When the SMSwas added to the SOFA score, prediction of 30-day mortality improved compared to SOFA score used alone [0.845 (0.777–0.899), p=0.022]. Conclusions: A sepsismortality score using baseline leukocytes count, PCT, IL-6 and ARE was derived, which predicted 30-day mortality with very good performance and added significant prognostic information to SOFA score. Elsevier BV 2018-01-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/61635/7/61635_Sepsis%20mortality%20score%20for%20the%20prediction%20_scopus.pdf application/pdf en http://irep.iium.edu.my/61635/13/61635_Sepsis%20mortality%20score%20for%20the%20prediction.pdf application/pdf en http://irep.iium.edu.my/61635/14/61635_Sepsis%20mortality%20score%20for%20the%20prediction_WOS.pdf Wan Mohd Shukeri, Wan Fadzlina and Md Ralib, Azrina and Abdullah, Norzamzila and Mat Nor, Mohd Basri (2018) Sepsis mortality score for the prediction of mortality in septic patients. Journal of Critical Care, 43. pp. 163-168. ISSN 0883-9441 E-ISSN 1557-8615 http://www.jccjournal.org/article/S0883-9441(17)30494-X/pdf 10.1016/j.jcrc.2017.09.009 |
| spellingShingle | R Medicine (General) Wan Mohd Shukeri, Wan Fadzlina Md Ralib, Azrina Abdullah, Norzamzila Mat Nor, Mohd Basri Sepsis mortality score for the prediction of mortality in septic patients |
| title | Sepsis mortality score for the prediction of mortality in septic patients |
| title_full | Sepsis mortality score for the prediction of mortality in septic patients |
| title_fullStr | Sepsis mortality score for the prediction of mortality in septic patients |
| title_full_unstemmed | Sepsis mortality score for the prediction of mortality in septic patients |
| title_short | Sepsis mortality score for the prediction of mortality in septic patients |
| title_sort | sepsis mortality score for the prediction of mortality in septic patients |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/61635/ http://irep.iium.edu.my/61635/ http://irep.iium.edu.my/61635/ http://irep.iium.edu.my/61635/7/61635_Sepsis%20mortality%20score%20for%20the%20prediction%20_scopus.pdf http://irep.iium.edu.my/61635/13/61635_Sepsis%20mortality%20score%20for%20the%20prediction.pdf http://irep.iium.edu.my/61635/14/61635_Sepsis%20mortality%20score%20for%20the%20prediction_WOS.pdf |