The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection
The prevalence of implant associated with infection remains high. The management of this incidence poses a major challenge in orthopedic field. Colonization of bacterial and biofilm adhesion on implant may lead to infection at underlying bone and surrounding tissues. The infection risks may be overc...
| Main Authors: | , , , , |
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| Format: | Proceeding Paper |
| Language: | English English English English |
| Published: |
Elsevier
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/61449/ http://irep.iium.edu.my/61449/16/61449-The%20in-vitro%20and%20in%20vivo%20evaluations.pdf http://irep.iium.edu.my/61449/17/Best%20Poster%20Award%20Bio-Cam%202017%20Langkawi.pdf http://irep.iium.edu.my/61449/26/61449%20%20The%20in-vitro%20and%20in%20vivo%20evaluations%20of%20orthopedic.pdf http://irep.iium.edu.my/61449/27/61449%20%20The%20in-vitro%20and%20in%20vivo%20evaluations%20of%20orthopedic%20SCOPUS.pdf |
| _version_ | 1848785674570825728 |
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| author | Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah Mohd Toff, Mohd Radzi |
| author_facet | Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah Mohd Toff, Mohd Radzi |
| author_sort | Mohd Jan, Nurul Hafiza |
| building | IIUM Repository |
| collection | Online Access |
| description | The prevalence of implant associated with infection remains high. The management of this incidence poses a major challenge in orthopedic field. Colonization of bacterial and biofilm adhesion on implant may lead to infection at underlying bone and surrounding tissues. The infection risks may be overcome by application of orthopaedic metallic implant coated with silver composite (OMICS) as alternative treatment of implant-infection related. The aimed of these studies were to evaluate the potential effect of orthopedic metal implant (plate) coated with silver composite through in vitro and in vivo experimental settings. Antimicrobial test through in vitro analysis indicated that OMICS showed excellent response of antibacterial agent against Staphylococcus aureus. The effects of OMICS on open fracture related with infection were assessed in New Zealand White Rabbit models. All rabbits were implanted with OMICS after six hours of tibial bone exposure. The implanted tibia was excised en bloc and evaluated by means of microbial assessments, radiography evaluation, gross inspection and histological analysis for any infection effects. After 3 weeks of implantation, microbial analysis revealed fewer colonies were noted at study group compared to control. By combining the radiograph, gross and histological data collected during the experimental follow up, there is no periosteal reaction noted at the surrounding on implanted area. The outcome of this study revealed positive response of the silver as antibacterial agent. These studies indicated that silver has antibacterial properties. In conclusion, these values suggested that orthopaedic metal implant coated with silver composite may have the potential to prevent implant related infections. |
| first_indexed | 2025-11-14T16:56:54Z |
| format | Proceeding Paper |
| id | iium-61449 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English English |
| last_indexed | 2025-11-14T16:56:54Z |
| publishDate | 2019 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-614492019-10-11T01:04:25Z http://irep.iium.edu.my/61449/ The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah Mohd Toff, Mohd Radzi RD701 Orthopedics The prevalence of implant associated with infection remains high. The management of this incidence poses a major challenge in orthopedic field. Colonization of bacterial and biofilm adhesion on implant may lead to infection at underlying bone and surrounding tissues. The infection risks may be overcome by application of orthopaedic metallic implant coated with silver composite (OMICS) as alternative treatment of implant-infection related. The aimed of these studies were to evaluate the potential effect of orthopedic metal implant (plate) coated with silver composite through in vitro and in vivo experimental settings. Antimicrobial test through in vitro analysis indicated that OMICS showed excellent response of antibacterial agent against Staphylococcus aureus. The effects of OMICS on open fracture related with infection were assessed in New Zealand White Rabbit models. All rabbits were implanted with OMICS after six hours of tibial bone exposure. The implanted tibia was excised en bloc and evaluated by means of microbial assessments, radiography evaluation, gross inspection and histological analysis for any infection effects. After 3 weeks of implantation, microbial analysis revealed fewer colonies were noted at study group compared to control. By combining the radiograph, gross and histological data collected during the experimental follow up, there is no periosteal reaction noted at the surrounding on implanted area. The outcome of this study revealed positive response of the silver as antibacterial agent. These studies indicated that silver has antibacterial properties. In conclusion, these values suggested that orthopaedic metal implant coated with silver composite may have the potential to prevent implant related infections. Elsevier 2019 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/61449/16/61449-The%20in-vitro%20and%20in%20vivo%20evaluations.pdf application/pdf en http://irep.iium.edu.my/61449/17/Best%20Poster%20Award%20Bio-Cam%202017%20Langkawi.pdf application/pdf en http://irep.iium.edu.my/61449/26/61449%20%20The%20in-vitro%20and%20in%20vivo%20evaluations%20of%20orthopedic.pdf application/pdf en http://irep.iium.edu.my/61449/27/61449%20%20The%20in-vitro%20and%20in%20vivo%20evaluations%20of%20orthopedic%20SCOPUS.pdf Mohd Jan, Nurul Hafiza and Zulkifly, Ahmad Hafiz and Ibrahim, Mohd Zulfadzli and Sha'ban, Munirah and Mohd Toff, Mohd Radzi (2019) The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection. In: Bio-CAM 2017 Conference on Biomedical & Advanced Material, 28th-29th November 2017, Langkawi, Kedah. https://www.sciencedirect.com/science/article/pii/S2214785319314336 10.1016/j.matpr.2019.06.084 |
| spellingShingle | RD701 Orthopedics Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah Mohd Toff, Mohd Radzi The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection |
| title | The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection |
| title_full | The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection |
| title_fullStr | The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection |
| title_full_unstemmed | The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection |
| title_short | The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection |
| title_sort | in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: potential treatment modality for implant related infection |
| topic | RD701 Orthopedics |
| url | http://irep.iium.edu.my/61449/ http://irep.iium.edu.my/61449/ http://irep.iium.edu.my/61449/ http://irep.iium.edu.my/61449/16/61449-The%20in-vitro%20and%20in%20vivo%20evaluations.pdf http://irep.iium.edu.my/61449/17/Best%20Poster%20Award%20Bio-Cam%202017%20Langkawi.pdf http://irep.iium.edu.my/61449/26/61449%20%20The%20in-vitro%20and%20in%20vivo%20evaluations%20of%20orthopedic.pdf http://irep.iium.edu.my/61449/27/61449%20%20The%20in-vitro%20and%20in%20vivo%20evaluations%20of%20orthopedic%20SCOPUS.pdf |