Understanding evolutionary processes in bird species using genome-wide sequence analysis
Meiotic recombination is the driving force behind genetic diversity. It happens non-randomly across the genome, with high concentrations in regions called recombination hot spots. Across mammalian species, PRDM9 has shown to be an important player in localizing almost all meiotic recombination hot s...
| Main Authors: | , |
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
2017
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| Online Access: | http://irep.iium.edu.my/60944/ http://irep.iium.edu.my/60944/7/arcsb2017.pdf |
| _version_ | 1848785580241977344 |
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| author | Eltayeb, Muhammad Alfatih Tumian, Afidalina |
| author_facet | Eltayeb, Muhammad Alfatih Tumian, Afidalina |
| author_sort | Eltayeb, Muhammad Alfatih |
| building | IIUM Repository |
| collection | Online Access |
| description | Meiotic recombination is the driving force behind genetic diversity. It happens non-randomly across the genome, with high concentrations in regions called recombination hot spots. Across mammalian species, PRDM9 has shown to be an important player in localizing almost all meiotic recombination hot spots. However in some species such as birds and dogs, it is discovered that the localization of hot spots is unlikely to be regulated by PRDM9 due to disruption to its coding sequence. The rapid evolution of PRDM9 maybe a response to escape the self-disruptive drive called biased gene conversion (BGC). In this paper, we attempt to uncover if we can see any signatures of BGC in bird species by using alignment data consisting of the chicken, domestic turkey, zebra finch and the green anole. By studying relative motif losses and gains across the genomes, we aim to understand the biases and target sites/motifs and consequently to infer recombination lifetimes. |
| first_indexed | 2025-11-14T16:55:24Z |
| format | Proceeding Paper |
| id | iium-60944 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:55:24Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-609442018-01-23T07:15:36Z http://irep.iium.edu.my/60944/ Understanding evolutionary processes in bird species using genome-wide sequence analysis Eltayeb, Muhammad Alfatih Tumian, Afidalina QH301 Biology QH426 Genetics Meiotic recombination is the driving force behind genetic diversity. It happens non-randomly across the genome, with high concentrations in regions called recombination hot spots. Across mammalian species, PRDM9 has shown to be an important player in localizing almost all meiotic recombination hot spots. However in some species such as birds and dogs, it is discovered that the localization of hot spots is unlikely to be regulated by PRDM9 due to disruption to its coding sequence. The rapid evolution of PRDM9 maybe a response to escape the self-disruptive drive called biased gene conversion (BGC). In this paper, we attempt to uncover if we can see any signatures of BGC in bird species by using alignment data consisting of the chicken, domestic turkey, zebra finch and the green anole. By studying relative motif losses and gains across the genomes, we aim to understand the biases and target sites/motifs and consequently to infer recombination lifetimes. 2017-11-20 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/60944/7/arcsb2017.pdf Eltayeb, Muhammad Alfatih and Tumian, Afidalina (2017) Understanding evolutionary processes in bird species using genome-wide sequence analysis. In: The 4th Asian Regional Conference on Systems Biology 2017 (ARCSB2017), 20th-22nd November 2017, Marriott Hotel, Putrajaya. (Unpublished) http://arcsb2017.weebly.com/about.html |
| spellingShingle | QH301 Biology QH426 Genetics Eltayeb, Muhammad Alfatih Tumian, Afidalina Understanding evolutionary processes in bird species using genome-wide sequence analysis |
| title | Understanding evolutionary processes in bird species using genome-wide sequence analysis |
| title_full | Understanding evolutionary processes in bird species using genome-wide sequence analysis |
| title_fullStr | Understanding evolutionary processes in bird species using genome-wide sequence analysis |
| title_full_unstemmed | Understanding evolutionary processes in bird species using genome-wide sequence analysis |
| title_short | Understanding evolutionary processes in bird species using genome-wide sequence analysis |
| title_sort | understanding evolutionary processes in bird species using genome-wide sequence analysis |
| topic | QH301 Biology QH426 Genetics |
| url | http://irep.iium.edu.my/60944/ http://irep.iium.edu.my/60944/ http://irep.iium.edu.my/60944/7/arcsb2017.pdf |