Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study
The best described pharmacological property of flavonoids is their capacity to act as potent antioxidant that has been reported to play an important role in the alleviation of diabetes mellitus. Flavonoids biochemical properties are structure dependent; however, they are yet to be thoroughly underst...
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| Format: | Article |
| Language: | English English |
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Hindawi Publishing Corporation
2017
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| Online Access: | http://irep.iium.edu.my/60855/ http://irep.iium.edu.my/60855/1/Murni%20article%201_BioMed%20Research%20International%202017.pdf http://irep.iium.edu.my/60855/7/60855_Antioxidant%20and%20antidiabetic%20effects%20of%20flavonoids_SCOPUS.pdf |
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| author | Sarian, Murni Nazira Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Alhassan, Alhassan Muhammad Murugesu, Suganya Perumal, Vikneswari Khatib, Alfi Latip, Jalifah |
| author_facet | Sarian, Murni Nazira Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Alhassan, Alhassan Muhammad Murugesu, Suganya Perumal, Vikneswari Khatib, Alfi Latip, Jalifah |
| author_sort | Sarian, Murni Nazira |
| building | IIUM Repository |
| collection | Online Access |
| description | The best described pharmacological property of flavonoids is their capacity to act as potent antioxidant that has been reported to play an important role in the alleviation of diabetes mellitus. Flavonoids biochemical properties are structure dependent; however, they are yet to be thoroughly understood. Hence, the main aim of this work was to investigate the antioxidant and antidiabetic properties of some structurally related flavonoids to identify key positions responsible, their correlation, and the effect of methylation and acetylation on the same properties. Antioxidant potential was evaluated through dot blot, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ABTS+ radical scavenging, ferric reducing antioxidant power (FRAP), and xanthine oxidase inhibitory (XOI) assays. Antidiabetic effect was investigated through α-glucosidase and dipeptidyl peptidase-4 (DPP-4) assays. Results showed that the total number and the configuration of hydroxyl groups played an important role in regulating antioxidant and antidiabetic properties in scavenging DPPH radical, ABTS+ radical, and FRAP assays and improved both α-glucosidase and DPP-4 activities. Presence of C-2-C-3 double bond and C-4 ketonic group are two essential structural features in the bioactivity of flavonoids especially for antidiabetic property. Methylation and acetylation of hydroxyl groups were found to diminish the in vitro antioxidant and antidiabetic properties of the flavonoids. |
| first_indexed | 2025-11-14T16:55:08Z |
| format | Article |
| id | iium-60855 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:55:08Z |
| publishDate | 2017 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-608552018-04-03T00:53:40Z http://irep.iium.edu.my/60855/ Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study Sarian, Murni Nazira Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Alhassan, Alhassan Muhammad Murugesu, Suganya Perumal, Vikneswari Khatib, Alfi Latip, Jalifah QD Chemistry The best described pharmacological property of flavonoids is their capacity to act as potent antioxidant that has been reported to play an important role in the alleviation of diabetes mellitus. Flavonoids biochemical properties are structure dependent; however, they are yet to be thoroughly understood. Hence, the main aim of this work was to investigate the antioxidant and antidiabetic properties of some structurally related flavonoids to identify key positions responsible, their correlation, and the effect of methylation and acetylation on the same properties. Antioxidant potential was evaluated through dot blot, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ABTS+ radical scavenging, ferric reducing antioxidant power (FRAP), and xanthine oxidase inhibitory (XOI) assays. Antidiabetic effect was investigated through α-glucosidase and dipeptidyl peptidase-4 (DPP-4) assays. Results showed that the total number and the configuration of hydroxyl groups played an important role in regulating antioxidant and antidiabetic properties in scavenging DPPH radical, ABTS+ radical, and FRAP assays and improved both α-glucosidase and DPP-4 activities. Presence of C-2-C-3 double bond and C-4 ketonic group are two essential structural features in the bioactivity of flavonoids especially for antidiabetic property. Methylation and acetylation of hydroxyl groups were found to diminish the in vitro antioxidant and antidiabetic properties of the flavonoids. Hindawi Publishing Corporation 2017-12-20 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60855/1/Murni%20article%201_BioMed%20Research%20International%202017.pdf application/pdf en http://irep.iium.edu.my/60855/7/60855_Antioxidant%20and%20antidiabetic%20effects%20of%20flavonoids_SCOPUS.pdf Sarian, Murni Nazira and Ahmed, Qamar Uddin and Mat So'ad, Siti Zaiton and Alhassan, Alhassan Muhammad and Murugesu, Suganya and Perumal, Vikneswari and Khatib, Alfi and Latip, Jalifah (2017) Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study. BioMed Research International, 2017. pp. 1-14. ISSN 2314-6133 E-ISSN 2314-6141 https://www.hindawi.com/journals/bmri/2017/8386065/ 10.1155/2017/8386065 |
| spellingShingle | QD Chemistry Sarian, Murni Nazira Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Alhassan, Alhassan Muhammad Murugesu, Suganya Perumal, Vikneswari Khatib, Alfi Latip, Jalifah Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study |
| title | Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study |
| title_full | Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study |
| title_fullStr | Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study |
| title_full_unstemmed | Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study |
| title_short | Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study |
| title_sort | antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/60855/ http://irep.iium.edu.my/60855/ http://irep.iium.edu.my/60855/ http://irep.iium.edu.my/60855/1/Murni%20article%201_BioMed%20Research%20International%202017.pdf http://irep.iium.edu.my/60855/7/60855_Antioxidant%20and%20antidiabetic%20effects%20of%20flavonoids_SCOPUS.pdf |