Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls
Early diagnosis of neurodegenerative diseases is of paramount importance for successful treatment. Lack of sensitive and early biomarkers for diagnosis of diseases like Parkinson’s disease (PD) is a handicapping problem for all movement disorders specialists. Using serum autoimmune antibodies (AI...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English English |
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Frontiers Media S.A.
2017
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| Online Access: | http://irep.iium.edu.my/60803/ http://irep.iium.edu.my/60803/1/Alpha%20Syneculin%20Frontier.pdf http://irep.iium.edu.my/60803/7/60803_Elevated%20serum_scopus.pdf |
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| author | Shalash, Ali Salama, Mohamed Makar, Marianne Roushdy, Tamer Elrassas, Hannan hany Mohamed, Wael Mohamed Yousef ElBalkimy, Mahmoud Abu Donia, Mohamed |
| author_facet | Shalash, Ali Salama, Mohamed Makar, Marianne Roushdy, Tamer Elrassas, Hannan hany Mohamed, Wael Mohamed Yousef ElBalkimy, Mahmoud Abu Donia, Mohamed |
| author_sort | Shalash, Ali |
| building | IIUM Repository |
| collection | Online Access |
| description | Early diagnosis of neurodegenerative diseases is of paramount importance for successful
treatment. Lack of sensitive and early biomarkers for diagnosis of diseases
like Parkinson’s disease (PD) is a handicapping problem for all movement disorders
specialists. Using serum autoimmune antibodies (AIAs) against neural proteins is a new
promising strategy to diagnose brain disorders through non-invasive and cost-effective
method. In the present study, we measured the level of AIAs against α-synuclein (α-syn),
which is an important protein involved in the pathogenesis of PD. In our study patients
with PD (46 patients), Alzheimer’s disease (AD) (27 patients) and healthy controls (20
patients) were evaluated according to their sera α-syn AIAs levels. Interestingly, α-syn
AIAs were significantly elevated in PD group compared to AD and healthy controls,
which advocates their use for diagnosis of PD. |
| first_indexed | 2025-11-14T16:54:58Z |
| format | Article |
| id | iium-60803 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:54:58Z |
| publishDate | 2017 |
| publisher | Frontiers Media S.A. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-608032018-04-20T04:23:39Z http://irep.iium.edu.my/60803/ Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls Shalash, Ali Salama, Mohamed Makar, Marianne Roushdy, Tamer Elrassas, Hannan hany Mohamed, Wael Mohamed Yousef ElBalkimy, Mahmoud Abu Donia, Mohamed R Medicine (General) Early diagnosis of neurodegenerative diseases is of paramount importance for successful treatment. Lack of sensitive and early biomarkers for diagnosis of diseases like Parkinson’s disease (PD) is a handicapping problem for all movement disorders specialists. Using serum autoimmune antibodies (AIAs) against neural proteins is a new promising strategy to diagnose brain disorders through non-invasive and cost-effective method. In the present study, we measured the level of AIAs against α-synuclein (α-syn), which is an important protein involved in the pathogenesis of PD. In our study patients with PD (46 patients), Alzheimer’s disease (AD) (27 patients) and healthy controls (20 patients) were evaluated according to their sera α-syn AIAs levels. Interestingly, α-syn AIAs were significantly elevated in PD group compared to AD and healthy controls, which advocates their use for diagnosis of PD. Frontiers Media S.A. 2017-12-22 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60803/1/Alpha%20Syneculin%20Frontier.pdf application/pdf en http://irep.iium.edu.my/60803/7/60803_Elevated%20serum_scopus.pdf Shalash, Ali and Salama, Mohamed and Makar, Marianne and Roushdy, Tamer and Elrassas, Hannan hany and Mohamed, Wael Mohamed Yousef and ElBalkimy, Mahmoud and Abu Donia, Mohamed (2017) Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls. Frontiers in Neurology, 8. pp. 1-6. ISSN 1664-2295 https://www.frontiersin.org/articles/10.3389/fneur.2017.00720/full 10.3389/fneur.2017.00720 |
| spellingShingle | R Medicine (General) Shalash, Ali Salama, Mohamed Makar, Marianne Roushdy, Tamer Elrassas, Hannan hany Mohamed, Wael Mohamed Yousef ElBalkimy, Mahmoud Abu Donia, Mohamed Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls |
| title | Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls |
| title_full | Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls |
| title_fullStr | Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls |
| title_full_unstemmed | Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls |
| title_short | Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls |
| title_sort | elevated serum α-synuclein autoantibodies in patients with parkinson’s disease relative to alzheimer’s disease and controls |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/60803/ http://irep.iium.edu.my/60803/ http://irep.iium.edu.my/60803/ http://irep.iium.edu.my/60803/1/Alpha%20Syneculin%20Frontier.pdf http://irep.iium.edu.my/60803/7/60803_Elevated%20serum_scopus.pdf |