Porcupine bezoar exhibit cell cycle arrest through inhibiting cyclin /CDK1 complex
and apoptosis mitochondria mediated dependent pathway in A549 cells

QR Code

Porcupine bezoar exhibit cell cycle arrest through inhibiting cyclin /CDK1 complex and apoptosis mitochondria mediated dependent pathway in A549 cells

Porcupine bezoar (PB) previously reported to possess various medical properties, however there is no information on its potential anticancer effect on human cancer cells. In this study we investigate potential apoptotic effects induced by PB extracts in A549 cells and elucidate the underlying mec...

Full description

Bibliographic Details
Main Authors:	Firus Khan, Al'aina Yuhainis, Abdullah Asuhaimi, Faizah, Abdull Rasad, Mohammad Syaiful Bahari, Mohamad, Mardhiah, Hashim, Ridzwan, Mamat, Suhana, Johan, Muhammad Farid, Abdul Wahab, Ridhwan
Format:	Proceeding Paper
Language:	English
Published:	2016
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/60467/ http://irep.iium.edu.my/60467/1/pan%20asian.pdf

Similar Items

Porcupine bezoar exhibit as anti-cancer activities on human breast adenocarcinoma cells (MCF-7)
by: Firus Khan, Al'aina Yuhainis, et al.
Published: (2016)

In vitro evaluation of porcupine bezoar extracts as anticancer agent on A549 -A preliminary study
by: Firus Khan, Al'aina Yuhainis, et al.
Published: (2017)

Porcupine bezoar: in vitro antioxidant and anti-proliferative effects
by: Abdullah Asuhaimi, Faizah, et al.
Published: (2017)

Investigation of porcupine bezoar extract combined with electroporation on HeLa cell
by: Azizulkarim, Azra Hazwanie, et al.
Published: (2019)

Investigation of porcupine bezoar extract (Hystrix Brachyuran) on hela cell combined with electroporation method
by: Azizulkarim, Azra Hazwanie
Published: (2019)

Investigation on anti-proliferation properties of porcupine bezoar (hystrix brachyuran) extracts exposed on hela cells lines combined with electroporation technique
by: Azizulkarim, Azra Hazwanie, et al.
Published: (2018)

In-vitro evaluation of porcupine bezoar extracts (PBE) as anti-cancer agent on HeLa cell line – A preliminary study
by: Azizulkarim, Azra Hazwanie, et al.
Published: (2018)

Hystrix brachyura bezoar characterization, antioxidant activity screening, and anticancer activity on melanoma cells (A375): a preliminary study
by: Firus Khan, Al'aina Yuhanis, et al.
Published: (2019)

Anticancer activity of grassy Hystrix brachyura bezoar and its mechanisms of action: An in vitro and in vivo based study
by: Khan, Al’aina Yuhainis Firus, et al.
Published: (2019)

Anticancer activity of grassy Hystrix brachyura bezoar and its mechanisms of action: An in vitro and in vivo based study
by: Firus Khan, Al’aina Yuhainis, et al.
Published: (2019)

In-vitro cytotoxicity of Trigona itama honey against human lung adenocarcinoma epithelial cell line (A549)
by: Mohd Salim, Siti Norfitrah, et al.
Published: (2019)

Clinicopathological Analysis And Mrna Expression Profiling Of G1/S Phase Cyclins And Cdk4 In Formalin Fixed Paraffin Embedded Colorectal Cancer Tissue
by: Gururuloo, Sarminiyy Lenga
Published: (2024)

Identification and quantification of quercetin, a major constituent of Artocarpus altilis by targeting related genes of apoptosis and cell cycle: in vitro cytotoxic activity against human lung carcinoma cell lines
by: Jalal, Tara Kamal, et al.
Published: (2019)

Pomegranate juice induced cell cycle arrest and apoptosis through mitochondria pathway in human lung adenocarcinoma cells
by: Abdul Ghani, Radiah, et al.
Published: (2018)

Gene expression of CDK6 and CCND1 genes in basal cell carcinoma
by: Eshkoor, Sima Ataollahi, et al.
Published: (2008)

Microfluidic hydrodynamic trapping for single cell analysis: mechanisms, methods and applications
by: Vigneswaran, Narayanamurthy, et al.
Published: (2017)

Expression of CCND1, P16 and CDK6 in Human Basal Cell Carcinoma
by: Eshkoor, Sima Ataollahi
Published: (2007)

Recent advances in apoptosis, mitochondria and drug resistance in cancer cells
by: Indran, I., et al.
Published: (2011)

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor
by: Whittaker, Steven R., et al.
Published: (2018)

Comparative analysis of the surface interaction properties of the binding sites of CDK2, CDK4 and ERK2
by: Kelly, M., et al.
Published: (2006)

Cyclin d1 amplification in tongue and buccal mucosa squamous cell carcinoma / Haydar M. Mahdey
by: Mahdey, Haydar M.
Published: (2010)

Sand bezoar: A very rare cause of intussusception
by: Azhar AH,, et al.
Published: (2011)

Chemopreventive effect of Punica granatum in human lung carcinoma A549 cells
by: Nik Abdul Malek, Nik Nurasyikin, et al.
Published: (2014)

Chemopreventive effect of punica granatum on human lung carcinoma A549 cells
by: Abdul Ghani, Radiah, et al.
Published: (2014)

Understanding of anti-cancer properties of neolamarckia cadamba leaves extract on breast cancer cell
by: Razali, Shakirah, et al.
Published: (2017)

Reactive oxygen species, mitochondria, and endothelial cell death during in vitro simulated dives
by: Wang, Q., et al.
Published: (2015)

Cancer chemoprevention study of luffa aegyptiaca (sponge gourd) seed extract on human breast cancer cell lines (MCF-7)
by: Hassan, Habibah, et al.
Published: (2016)

Basic techniques and research in cell culture: integration of Islamic approach
by: Abdull Rasad, Mohammad Syaiful Bahari
Published: (2014)

The role of mitochondria in ageing
by: Pollard, Amelia K.
Published: (2017)

Identification of deregulation in protein expression level of erlotinib-resistant A549 cell lines
by: Mohd Noh, Noor Khafizah
Published: (2015)

The effects of Ficus auriculata (fig) on cell cycle profile and apoptosis activity of Human lung adenocarcinoma cells, A549
by: Jamil, Elyna Fatini, et al.
Published: (2016)

Porcupine burrow distribution in relation to soil types in Sarawak, Malaysia
by: Mohd. Top @ Mohd Tah, Marina, et al.
Published: (2015)

Understanding of anti-cancer properties of Neolamarckia cadamba (Kalempayan) leaves extract on breast cancer cell
by: Razali, Shakirah, et al.
Published: (2016)

A lncRNA transcriptome analysis of phycocyanin-treated non-small cell lung cancer A549 cell lines
by: Wu, Boxiong, et al.
Published: (2024)

Evaluation of the cytotoxic effect of ellagic acid nanocomposite in lung cancer A549 cell line and RAW 264.9 cells
by: Hussein Al-Ali, Samer Hasan Ahmad, et al.
Published: (2017)

Study on cancer prevention strategy by Punica granatum: the role of polyamines in regulating cell cycle and cell death in human lung carcinoma A549 cells
by: Nik Abdul Malek, Nik Nurasyikin, et al.
Published: (2016)

Antiproliferative activity of selected prophetic medicinal plants on human lung adenocarcinoma cells, A549
by: Abdul Ghani, Radiah, et al.
Published: (2015)

Induction of apoptosis in A549 cells in vitro by Boesenbergin A isolated from Boesenbergia rotunda
by: Mohd Isa, Norbaiti
Published: (2013)

Cyclin dependent Kinases as potential therapeutic targets for atherosclerosis
by: Rostam, Muhamad Ashraf, et al.
Published: (2015)

Analysis of CDK13-related disorder in a mouse model
by: Abbad, Aseel
Published: (2024)