Electrospun polycaprolactone nanofibres decorated by drug loaded chitosan nano- reservoirs for antibacterial treatments
The main limitation of conventional antibiotic therapies concerns the low efficacy to fight bacteria attacks during long treatment times. In this context, the integrated use of electrofluidodynamics (EFDs)—basically electrospinning and electrospraying—may represent an interesting route for designing...
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| Format: | Article |
| Language: | English English |
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IOP Publishing
2017
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| Online Access: | http://irep.iium.edu.my/60451/ http://irep.iium.edu.my/60451/1/Vincenzo%20et%20al%202017.pdf http://irep.iium.edu.my/60451/7/60451_%20Electrospun%20polycaprolactone%20nanofibres_scopus.pdf |
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| author | Guarino, V Cruz-Maya, Iriczalli Altobelli, Rosaria Abdul Khodir, Wan Khartini Ambrosio, Luigi Alvarez Pèrez, Marco A Almaguer Flores, Argelia |
| author_facet | Guarino, V Cruz-Maya, Iriczalli Altobelli, Rosaria Abdul Khodir, Wan Khartini Ambrosio, Luigi Alvarez Pèrez, Marco A Almaguer Flores, Argelia |
| author_sort | Guarino, V |
| building | IIUM Repository |
| collection | Online Access |
| description | The main limitation of conventional antibiotic therapies concerns the low efficacy to fight bacteria attacks during long treatment times. In this context, the integrated use of electrofluidodynamics (EFDs)—basically electrospinning and electrospraying—may represent an interesting route for designing nanostructured platforms with controlled release to prevent the formation of bacterial biofilms in oral implant sites. They allow for the deposition of nanofibres and nanoparticles by different modes—i.e. sequential, simultaneous—for the fabrication of more efficacious systems in terms of degradation protection, pharmacokinetic control and drug distribution to the surrounding tissues. Herein, we will investigate EFDs processing modes and conditions to decorate polycaprolactone nanofibres surfaces by chitosan nano-reservoirs for the administration of Amoxicillin Trihydrate as an innovative antibacterial treatment of the periodontal pocket. |
| first_indexed | 2025-11-14T16:54:03Z |
| format | Article |
| id | iium-60451 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:54:03Z |
| publishDate | 2017 |
| publisher | IOP Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-604512018-04-20T04:14:08Z http://irep.iium.edu.my/60451/ Electrospun polycaprolactone nanofibres decorated by drug loaded chitosan nano- reservoirs for antibacterial treatments Guarino, V Cruz-Maya, Iriczalli Altobelli, Rosaria Abdul Khodir, Wan Khartini Ambrosio, Luigi Alvarez Pèrez, Marco A Almaguer Flores, Argelia TA166 Human engineering The main limitation of conventional antibiotic therapies concerns the low efficacy to fight bacteria attacks during long treatment times. In this context, the integrated use of electrofluidodynamics (EFDs)—basically electrospinning and electrospraying—may represent an interesting route for designing nanostructured platforms with controlled release to prevent the formation of bacterial biofilms in oral implant sites. They allow for the deposition of nanofibres and nanoparticles by different modes—i.e. sequential, simultaneous—for the fabrication of more efficacious systems in terms of degradation protection, pharmacokinetic control and drug distribution to the surrounding tissues. Herein, we will investigate EFDs processing modes and conditions to decorate polycaprolactone nanofibres surfaces by chitosan nano-reservoirs for the administration of Amoxicillin Trihydrate as an innovative antibacterial treatment of the periodontal pocket. IOP Publishing 2017-11-23 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60451/1/Vincenzo%20et%20al%202017.pdf application/pdf en http://irep.iium.edu.my/60451/7/60451_%20Electrospun%20polycaprolactone%20nanofibres_scopus.pdf Guarino, V and Cruz-Maya, Iriczalli and Altobelli, Rosaria and Abdul Khodir, Wan Khartini and Ambrosio, Luigi and Alvarez Pèrez, Marco A and Almaguer Flores, Argelia (2017) Electrospun polycaprolactone nanofibres decorated by drug loaded chitosan nano- reservoirs for antibacterial treatments. Nanotechnology, 28 (50). pp. 1-9. ISSN 0957-4484 E-ISSN 1361-6528 http://iopscience.iop.org/journal/0957-4484 10.1088/1361-6528/aa9542 |
| spellingShingle | TA166 Human engineering Guarino, V Cruz-Maya, Iriczalli Altobelli, Rosaria Abdul Khodir, Wan Khartini Ambrosio, Luigi Alvarez Pèrez, Marco A Almaguer Flores, Argelia Electrospun polycaprolactone nanofibres decorated by drug loaded chitosan nano- reservoirs for antibacterial treatments |
| title | Electrospun polycaprolactone nanofibres decorated by drug loaded chitosan nano- reservoirs for antibacterial treatments |
| title_full | Electrospun polycaprolactone nanofibres decorated by drug loaded chitosan nano- reservoirs for antibacterial treatments |
| title_fullStr | Electrospun polycaprolactone nanofibres decorated by drug loaded chitosan nano- reservoirs for antibacterial treatments |
| title_full_unstemmed | Electrospun polycaprolactone nanofibres decorated by drug loaded chitosan nano- reservoirs for antibacterial treatments |
| title_short | Electrospun polycaprolactone nanofibres decorated by drug loaded chitosan nano- reservoirs for antibacterial treatments |
| title_sort | electrospun polycaprolactone nanofibres decorated by drug loaded chitosan nano- reservoirs for antibacterial treatments |
| topic | TA166 Human engineering |
| url | http://irep.iium.edu.my/60451/ http://irep.iium.edu.my/60451/ http://irep.iium.edu.my/60451/ http://irep.iium.edu.my/60451/1/Vincenzo%20et%20al%202017.pdf http://irep.iium.edu.my/60451/7/60451_%20Electrospun%20polycaprolactone%20nanofibres_scopus.pdf |