CDK9 inhibitors define elongation checkpoints at both ends of
RNA polymerase II-transcribed genes

QR Code

CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II-transcribed genes

Transcription through early-elongation checkpoints requires phosphorylation of negative transcription elongation factors (NTEFs) by the cyclin-dependent kinase (CDK)9. Using CDK9 inhibitors and global run-on sequencing (GRO-seq), we have mapped CDK9 inhibitor-sensitive checkpoints genome-wide in...

Full description

Bibliographic Details
Main Authors:	Laitem, Clélia, Zaborowska, Justyna, Isa, Nur Firdaus, Kufs, Johann, Dienstbier, Martin, Murphy, Shona
Format:	Article
Language:	English English
Published:	Nature Publishing Group 2015
Subjects:	Q Science (General) R Medicine (General)
Online Access:	http://irep.iium.edu.my/60432/ http://irep.iium.edu.my/60432/1/2015-NSMB.pdf http://irep.iium.edu.my/60432/7/60432_CDK9%20inhibitors%20define%20elongation_scopus.pdf

Similar Items

P-TEFb goes viral
by: Zaborowska, Justyna, et al.
Published: (2016)

Defining the meiotic functions of the checkpoint protein DPB11
by: Garnell, Thomas
Published: (2024)

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor
by: Whittaker, Steven R., et al.
Published: (2018)

Comparative analysis of the surface interaction properties of the binding sites of CDK2, CDK4 and ERK2
by: Kelly, M., et al.
Published: (2006)

Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells
by: Pallis, Monica, et al.
Published: (2013)

Analysis of CDK13-related disorder in a mouse model
by: Abbad, Aseel
Published: (2024)

The current status of checkpoint inhibitors in metastatic bladder cancer
by: Fahmy Ahmed, Omar Ahmed, et al.
Published: (2016)

Molecular characterization of 16S rRNA and internal transcribed spacer (ITS) regions of Aeromonas spp. isolated from cultured freshwater fishes in Malaysia
by: K.P., Diyana Nadhirah, et al.
Published: (2016)

Characterization of 16S rRNA and internal transcribed spacer (ITS) region gene sequencing of the Aeromonas species isolated from cultured freshwater fishes
by: Khairul Parman, Diyana Nadhirah
Published: (2013)

Species identification of potential probiotic lactic acid bacteria isolated from Malaysian fermented food based on 16S ribosomal RNA (16S rRNA) and internal transcribed spacer (ITS) sequences
by: Yaacob Ilyanie,, et al.
Published: (2023)

Elongation of the poly-γ-glutamate tail of F420 requires both domains of the F420:γ-glutamyl ligase (FbiB) of Mycobacterium tuberculosis
by: Bashiri, Ghader, et al.
Published: (2016)

Design, synthesis, and optimisation of highly selective macrocyclic CDK9 inhibitors
by: Gao, Rui
Published: (2018)

A new efficient checkpointing algorithm for distributed mobile computing
by: Mansouri, Houssem, et al.
Published: (2015)

Immune checkpoint inhibition: Prospects for prevention and therapy of hepatocellular carcinoma
by: Elsegood, Caryn, et al.
Published: (2017)

Performance comparison between bootstrap and multiscale bootstrap for assessing phylogenetic tree for RNA polymerase
by: Safinah Sharuddin,, et al.
Published: (2015)

A fiber bragg grating-based gap elongation sensor for the detection of gap elongation in bolted flange connection
by: Nur Ainaa Adhreena, Muhamad Shukri, et al.
Published: (2022)

Structure of a heavily transcribed region of barley chloroplast DNA. Transfer RNA genes for serine (UGA), glycine (GCC, UCC), formyl-methionine and threonine (GGU)
by: Oliver, Richard, et al.
Published: (1984)

A Cdk1 phosphomimic mutant of MCAK impairs microtubule end recognition
by: Belsham, Hannah R., et al.
Published: (2017)

The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response
by: Barone, Giancarlo, et al.
Published: (2018)

Gene expression of CDK6 and CCND1 genes in basal cell carcinoma
by: Eshkoor, Sima Ataollahi, et al.
Published: (2008)

Optimisation of reverse transcription-polymerase chain reaction for double stranded RNA extraction / Jamiila Ismail
by: Ismail, Jamiila
Published: (2007)

A non-blocking coordinated checkpointing algorithm for message-passing systems
by: Mansouri, Houssem, et al.
Published: (2015)

Aging induces increased expression of checkpoint inhibitory molecules on dendritic cells
by: Gardner, J., et al.
Published: (2016)

Checkpointing in selected most fitted resource task scheduling in grid computing
by: Latip, Rohaya, et al.
Published: (2012)

Molecular insights into the regulation of rice kernel elongation
by: Nazarali, Parisa Azizi, et al.
Published: (2019)

Detection and Differentiation of Malaysian Newcastle Disease Virus Isolates by RNA-Polymerase Chain Reaction and Cycle Sequencing
by: Ng, Ban Kim
Published: (1995)

Development of a stable T7 RNA polymerase expressing cell line using a lentivirus system
by: Yeong, Ming Yue
Published: (2019)

Elucidating the role of Cdk13 and Prkd1 in heart development and congenital heart disease
by: Waheed Ullah, Qazi
Published: (2024)

Expression of CCND1, P16 and CDK6 in Human Basal Cell Carcinoma
by: Eshkoor, Sima Ataollahi
Published: (2007)

Kajian dok molekul mengenai interaksi antara RNA-bergantung RNA polimerase virus denggi dan analog nukleosida = Molecular docking study of the interactions between dengue virus RNA-dependent-RNA polymerase and nucleoside analogues
by: Abdullah, Nor Nadirah, et al.
Published: (2018)

Checkpoint localization for hikers using Havaersine Formula / Mohd Haizat Mat Isa
by: Mat Isa, Mohd Haizat
Published: (2015)

Hybrid vertex-midline modelling of elongated plant organs
by: Fozard, John A., et al.
Published: (2016)

Chemical components of polymerase chain reaction in 18s rRNA for detection of Cryptosporidium from river water samples
by: Barudin, Mohd Aiman, et al.
Published: (2019)

In situ hybridization and polymerase chain reaction methods for the detection of Epstein-Barr virus RNA in breast cancer specimens
by: Arif Shah, Izham Naquiddin Shah, et al.
Published: (2011)

Adaptive fault tolerant checkpointing algorithm for cluster based mobile Ad Hoc networks
by: Mansour, Houssem, et al.
Published: (2015)

In-house semi-nested reverse transcription polymerase chain reaction for the detection of HCV-RNA in serum with low viral load
by: Hamzah, Hairul Aini, et al.
Published: (2013)

Sequence analysis of RNA-dependent RNA polymerase and development of a TaqMan real-time RT-PCR assay for detection of Macrobrachium rosenbergii nodavirus in giant freshwater prawns
by: Mohammadi, Zeinabsadat
Published: (2012)

Multiscale modelling of auxin transport in the plant-root elongation zone
by: Band, Leah R., et al.
Published: (2012)

Vertex-element models for anisotropic growth of elongated plant organs
by: Fozard, John A., et al.
Published: (2013)

Elongated tufaceous stalagmites in the entrance of Batu Cave (Selangor, Malaysia)
by: Dodge-Wan, Dominique
Published: (2015)