In vivo study of the pharmacokinetic effect of amlodipine and gliclazide
It was found that there is kind of pharmacodynamic interaction between calcium channels blockers and sulfonylurea. The addition of amlodipine (AMLO) to gliclazide (GLZ) course caused significant decrease in glucose lowering effect of GLZ. The mechanism of AMLO-GLZ interaction is not well understood....
| Main Authors: | , , , |
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| Format: | Proceeding Paper |
| Language: | English |
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Centre of Lipids Engineering and Applied Research (CLEAR), Universiti Teknologi Malaysia (UTM)
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/60342/ http://irep.iium.edu.my/60342/1/ICOST%202017.pdf |
| _version_ | 1848785474216263680 |
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| author | Helal Uddin, A.B.M. Alaama, Mohammed Awang, Mohamed Abbas, Syed Atif |
| author_facet | Helal Uddin, A.B.M. Alaama, Mohammed Awang, Mohamed Abbas, Syed Atif |
| author_sort | Helal Uddin, A.B.M. |
| building | IIUM Repository |
| collection | Online Access |
| description | It was found that there is kind of pharmacodynamic interaction between calcium channels blockers and sulfonylurea. The addition of amlodipine (AMLO) to gliclazide (GLZ) course caused significant decrease in glucose lowering effect of GLZ. The mechanism of AMLO-GLZ interaction is not well understood. There is a possibility that this interaction can be a result of pharmacokinetic interaction of both drugs; therefore, this study was designed to investigate the pharmacokinetic interaction between AMLO and GLZ in animal model. The pharmacokinetic interaction was evaluated using Sprauge Dawly rates as they were divided into three groups. The controle group received saline and the gliclazide groupe received gliclazide orally in the dose of 1.44 mg/kg, while the Amlo-Gliclazide groupe has received amlodipine and gliclazide orally with a dose of 0.09 mg/kg and 1.44 mg/kg respectively. After dosing, animals were anesthetized and the blood was collected using retro orbital blood collection method after 1, 2, 4, 6, 8, 12, 24 hours of the dose. A new and novel LC-MS/MS method was developed and validated for the determination of GLZ in and rat plasma. The results showed that the pharmacokinetic parameters such as Cmax (ng/ml), Tmax (hr) were not altered significantly by AMLO administration. However, the administration of AMLO lead to significant increase (p = 0.000672) in AUC. In conclusion the plasma GLZ concentration increased when it was co administered with AMLO, while Cmax and Tmax remain unchanged. This study suggests that AMLO might reduce GLZ elimination. |
| first_indexed | 2025-11-14T16:53:43Z |
| format | Proceeding Paper |
| id | iium-60342 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:53:43Z |
| publishDate | 2017 |
| publisher | Centre of Lipids Engineering and Applied Research (CLEAR), Universiti Teknologi Malaysia (UTM) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-603422022-11-07T03:47:52Z http://irep.iium.edu.my/60342/ In vivo study of the pharmacokinetic effect of amlodipine and gliclazide Helal Uddin, A.B.M. Alaama, Mohammed Awang, Mohamed Abbas, Syed Atif QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry It was found that there is kind of pharmacodynamic interaction between calcium channels blockers and sulfonylurea. The addition of amlodipine (AMLO) to gliclazide (GLZ) course caused significant decrease in glucose lowering effect of GLZ. The mechanism of AMLO-GLZ interaction is not well understood. There is a possibility that this interaction can be a result of pharmacokinetic interaction of both drugs; therefore, this study was designed to investigate the pharmacokinetic interaction between AMLO and GLZ in animal model. The pharmacokinetic interaction was evaluated using Sprauge Dawly rates as they were divided into three groups. The controle group received saline and the gliclazide groupe received gliclazide orally in the dose of 1.44 mg/kg, while the Amlo-Gliclazide groupe has received amlodipine and gliclazide orally with a dose of 0.09 mg/kg and 1.44 mg/kg respectively. After dosing, animals were anesthetized and the blood was collected using retro orbital blood collection method after 1, 2, 4, 6, 8, 12, 24 hours of the dose. A new and novel LC-MS/MS method was developed and validated for the determination of GLZ in and rat plasma. The results showed that the pharmacokinetic parameters such as Cmax (ng/ml), Tmax (hr) were not altered significantly by AMLO administration. However, the administration of AMLO lead to significant increase (p = 0.000672) in AUC. In conclusion the plasma GLZ concentration increased when it was co administered with AMLO, while Cmax and Tmax remain unchanged. This study suggests that AMLO might reduce GLZ elimination. Centre of Lipids Engineering and Applied Research (CLEAR), Universiti Teknologi Malaysia (UTM) 2017-04 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/60342/1/ICOST%202017.pdf Helal Uddin, A.B.M. and Alaama, Mohammed and Awang, Mohamed and Abbas, Syed Atif (2017) In vivo study of the pharmacokinetic effect of amlodipine and gliclazide. In: 2nd International Conferenec on Separation Technology (ICoST) 2017, 15th-16th April 2017, Johor Bharu, Johor. https://clear.utm.my/icost2017/ |
| spellingShingle | QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry Helal Uddin, A.B.M. Alaama, Mohammed Awang, Mohamed Abbas, Syed Atif In vivo study of the pharmacokinetic effect of amlodipine and gliclazide |
| title | In vivo study of the pharmacokinetic effect of amlodipine and gliclazide |
| title_full | In vivo study of the pharmacokinetic effect of amlodipine and gliclazide |
| title_fullStr | In vivo study of the pharmacokinetic effect of amlodipine and gliclazide |
| title_full_unstemmed | In vivo study of the pharmacokinetic effect of amlodipine and gliclazide |
| title_short | In vivo study of the pharmacokinetic effect of amlodipine and gliclazide |
| title_sort | in vivo study of the pharmacokinetic effect of amlodipine and gliclazide |
| topic | QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry |
| url | http://irep.iium.edu.my/60342/ http://irep.iium.edu.my/60342/ http://irep.iium.edu.my/60342/1/ICOST%202017.pdf |