Role of therapeutic plasma exchange in severe thyrotoxicosis secondary to grave’s disease with several organ decompensation: a case report and review of literature
We report a case of 45 year-old lady whom had received therapeutic plasma exchange for severe thyrotoxicosis with several organ decompensations due to the overwhelming autoimmunity. She presented with symptoms of breathlessness, lethargy and atrial fibrillation with rapid ventricular response. She h...
| Main Authors: | , , |
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| Format: | Proceeding Paper |
| Language: | English English |
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2017
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| Online Access: | http://irep.iium.edu.my/59417/ http://irep.iium.edu.my/59417/1/TPE%20in%20severe%20thyrotoxicosis.pdf http://irep.iium.edu.my/59417/2/poster%20mac8%20180517-2.pdf |
| _version_ | 1848785309563617280 |
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| author | Rozi, Nur Raziana Zakaria, Miza Hiryanti Shahar, Mohammad Arif |
| author_facet | Rozi, Nur Raziana Zakaria, Miza Hiryanti Shahar, Mohammad Arif |
| author_sort | Rozi, Nur Raziana |
| building | IIUM Repository |
| collection | Online Access |
| description | We report a case of 45 year-old lady whom had received therapeutic plasma exchange for severe thyrotoxicosis with several organ decompensations due to the overwhelming autoimmunity. She presented with symptoms of breathlessness, lethargy and atrial fibrillation with rapid ventricular response. She had underlying, untreated Grave’s disease for several years. Her serum thyroxine levels were markedly elevated. Despite reduction in thyroid hormones levels after initial treatment with anti-thyroid drug and lugol’s iodine, her clinical condition deteriorated with hypotension, worsening respiratory distress, acute kidney injury and liver failure. We suspect that the overwhelming autoimmunity has led to the consequent organs decompensation. Therapeutic plasma exchange was initiated which resulted in improvement of the clinical and biochemical parameters and thus, potentially appears to have an effective role in a complicating, overwhelming autoimmunity of severe thyrotoxicosis secondary to Grave’s disease. |
| first_indexed | 2025-11-14T16:51:06Z |
| format | Proceeding Paper |
| id | iium-59417 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:51:06Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-594172017-11-20T03:33:12Z http://irep.iium.edu.my/59417/ Role of therapeutic plasma exchange in severe thyrotoxicosis secondary to grave’s disease with several organ decompensation: a case report and review of literature Rozi, Nur Raziana Zakaria, Miza Hiryanti Shahar, Mohammad Arif R Medicine (General) RC Internal medicine RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology We report a case of 45 year-old lady whom had received therapeutic plasma exchange for severe thyrotoxicosis with several organ decompensations due to the overwhelming autoimmunity. She presented with symptoms of breathlessness, lethargy and atrial fibrillation with rapid ventricular response. She had underlying, untreated Grave’s disease for several years. Her serum thyroxine levels were markedly elevated. Despite reduction in thyroid hormones levels after initial treatment with anti-thyroid drug and lugol’s iodine, her clinical condition deteriorated with hypotension, worsening respiratory distress, acute kidney injury and liver failure. We suspect that the overwhelming autoimmunity has led to the consequent organs decompensation. Therapeutic plasma exchange was initiated which resulted in improvement of the clinical and biochemical parameters and thus, potentially appears to have an effective role in a complicating, overwhelming autoimmunity of severe thyrotoxicosis secondary to Grave’s disease. 2017-05 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/59417/1/TPE%20in%20severe%20thyrotoxicosis.pdf application/pdf en http://irep.iium.edu.my/59417/2/poster%20mac8%20180517-2.pdf Rozi, Nur Raziana and Zakaria, Miza Hiryanti and Shahar, Mohammad Arif (2017) Role of therapeutic plasma exchange in severe thyrotoxicosis secondary to grave’s disease with several organ decompensation: a case report and review of literature. In: MEMS Annual Congress 2017 (MAC2017), 19th-21st May 2017, Kuala Lumpur. (Unpublished) http://www.mems.my/ |
| spellingShingle | R Medicine (General) RC Internal medicine RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology Rozi, Nur Raziana Zakaria, Miza Hiryanti Shahar, Mohammad Arif Role of therapeutic plasma exchange in severe thyrotoxicosis secondary to grave’s disease with several organ decompensation: a case report and review of literature |
| title | Role of therapeutic plasma exchange in severe thyrotoxicosis secondary to grave’s disease with several organ decompensation: a case report and review of literature |
| title_full | Role of therapeutic plasma exchange in severe thyrotoxicosis secondary to grave’s disease with several organ decompensation: a case report and review of literature |
| title_fullStr | Role of therapeutic plasma exchange in severe thyrotoxicosis secondary to grave’s disease with several organ decompensation: a case report and review of literature |
| title_full_unstemmed | Role of therapeutic plasma exchange in severe thyrotoxicosis secondary to grave’s disease with several organ decompensation: a case report and review of literature |
| title_short | Role of therapeutic plasma exchange in severe thyrotoxicosis secondary to grave’s disease with several organ decompensation: a case report and review of literature |
| title_sort | role of therapeutic plasma exchange in severe thyrotoxicosis secondary to grave’s disease with several organ decompensation: a case report and review of literature |
| topic | R Medicine (General) RC Internal medicine RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology |
| url | http://irep.iium.edu.my/59417/ http://irep.iium.edu.my/59417/ http://irep.iium.edu.my/59417/1/TPE%20in%20severe%20thyrotoxicosis.pdf http://irep.iium.edu.my/59417/2/poster%20mac8%20180517-2.pdf |