A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal aortic aneurysm
BACKGROUND: A double-blind, randomized controlled trial was carried out to study the effects of statins on matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in areas of peak and low abdominal aortic aneurysm (AAA) wall stress. METHODS: A total of 40 patie...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2011
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/59244/ http://irep.iium.edu.my/59244/1/A%20randomised%20placebo%20controlled%20trial%20of%20the%20effect%20of%20preoperative%20statin.pdf |
| _version_ | 1848785273550274560 |
|---|---|
| author | Abdul Rahman, Mohd Norhisham Azmi Khan, Junaidalam Mazari, Fayyaz Ali Khan Mockford, Katherine McCollum, Peter Thomas Chetter, Ian Clifford |
| author_facet | Abdul Rahman, Mohd Norhisham Azmi Khan, Junaidalam Mazari, Fayyaz Ali Khan Mockford, Katherine McCollum, Peter Thomas Chetter, Ian Clifford |
| author_sort | Abdul Rahman, Mohd Norhisham Azmi |
| building | IIUM Repository |
| collection | Online Access |
| description | BACKGROUND:
A double-blind, randomized controlled trial was carried out to study the effects of statins on matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in areas of peak and low abdominal aortic aneurysm (AAA) wall stress.
METHODS:
A total of 40 patients undergoing elective open AAA repair were randomized to receive either atorvastatin 80 mg (n = 20) or placebo (n = 20) for 4 weeks preoperatively. Finite element analysis was used to determine AAA wall stress distribution. Full thickness aortic samples were obtained at surgery from areas of low and peak wall stress, snap-frozen, and stored at -80°C for subsequent MMP-2, -8, and -9 and TIMP-1 and -2 analyses. Statistical analysis was performed using SPSS 16.0 (SPSS Inc, Chicago, IL).
RESULTS:
Both groups were well matched (p > 0.05) regarding age, gender, comorbidities, and duration of hospital stay. There were no statistically significant differences in levels of MMPs and TIMPs between the statin and placebo group and between areas of low and peak AAA wall stress.
CONCLUSION:
The short-term use of statins is not associated in reducing levels of MMP 2, 8, and 9 and TIMP-1 and -2 in areas of low and peak wall stress in patients with AAA. |
| first_indexed | 2025-11-14T16:50:31Z |
| format | Article |
| id | iium-59244 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:50:31Z |
| publishDate | 2011 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-592442017-11-10T02:23:50Z http://irep.iium.edu.my/59244/ A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal aortic aneurysm Abdul Rahman, Mohd Norhisham Azmi Khan, Junaidalam Mazari, Fayyaz Ali Khan Mockford, Katherine McCollum, Peter Thomas Chetter, Ian Clifford RD Surgery BACKGROUND: A double-blind, randomized controlled trial was carried out to study the effects of statins on matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in areas of peak and low abdominal aortic aneurysm (AAA) wall stress. METHODS: A total of 40 patients undergoing elective open AAA repair were randomized to receive either atorvastatin 80 mg (n = 20) or placebo (n = 20) for 4 weeks preoperatively. Finite element analysis was used to determine AAA wall stress distribution. Full thickness aortic samples were obtained at surgery from areas of low and peak wall stress, snap-frozen, and stored at -80°C for subsequent MMP-2, -8, and -9 and TIMP-1 and -2 analyses. Statistical analysis was performed using SPSS 16.0 (SPSS Inc, Chicago, IL). RESULTS: Both groups were well matched (p > 0.05) regarding age, gender, comorbidities, and duration of hospital stay. There were no statistically significant differences in levels of MMPs and TIMPs between the statin and placebo group and between areas of low and peak AAA wall stress. CONCLUSION: The short-term use of statins is not associated in reducing levels of MMP 2, 8, and 9 and TIMP-1 and -2 in areas of low and peak wall stress in patients with AAA. Elsevier 2011-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/59244/1/A%20randomised%20placebo%20controlled%20trial%20of%20the%20effect%20of%20preoperative%20statin.pdf Abdul Rahman, Mohd Norhisham Azmi and Khan, Junaidalam and Mazari, Fayyaz Ali Khan and Mockford, Katherine and McCollum, Peter Thomas and Chetter, Ian Clifford (2011) A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal aortic aneurysm. Annals of Vascular Surgery, 25 (1). pp. 32-38. ISSN 0890-5096 E-ISSN 1615-5947 http://www.annalsofvascularsurgery.com/article/S0890-5096(10)00300-6/fulltext 10.1016/j.avsg.2010.06.006 |
| spellingShingle | RD Surgery Abdul Rahman, Mohd Norhisham Azmi Khan, Junaidalam Mazari, Fayyaz Ali Khan Mockford, Katherine McCollum, Peter Thomas Chetter, Ian Clifford A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal aortic aneurysm |
| title | A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal aortic aneurysm |
| title_full | A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal aortic aneurysm |
| title_fullStr | A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal aortic aneurysm |
| title_full_unstemmed | A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal aortic aneurysm |
| title_short | A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal aortic aneurysm |
| title_sort | randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal aortic aneurysm |
| topic | RD Surgery |
| url | http://irep.iium.edu.my/59244/ http://irep.iium.edu.my/59244/ http://irep.iium.edu.my/59244/ http://irep.iium.edu.my/59244/1/A%20randomised%20placebo%20controlled%20trial%20of%20the%20effect%20of%20preoperative%20statin.pdf |