Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms
Background: The influence of intraluminal thrombus (ILT) on the proteolytic environment within the wall of an abdominal aortic aneurysm (AAA) is unknown. This is the first study to examine the correlation between ILT thickness and the levels of matrix metalloproteinases (MMPs) and their natural inhi...
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Elsevier
2012
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| Online Access: | http://irep.iium.edu.my/59158/ http://irep.iium.edu.my/59158/1/Intraluminal%20thrombus%20has%20a%20selective%20influence%20on%20matrix%20metalloproteinases%20and%20their%20inhibitors%20%28tissue%20inhibitors%20of%20matrix%20metalloproteinases%29%20in%20the%20wall%20of%20abdomin.pdf |
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| author | Khan, J. A. Abdul Rahman, Mohd Norhisham Azmi Mazari, F. A. K. Shahin, Y Smith, G Madden, L Fagan, M. J. Greenman, J McCollum, P. T. Chetter, I. C. |
| author_facet | Khan, J. A. Abdul Rahman, Mohd Norhisham Azmi Mazari, F. A. K. Shahin, Y Smith, G Madden, L Fagan, M. J. Greenman, J McCollum, P. T. Chetter, I. C. |
| author_sort | Khan, J. A. |
| building | IIUM Repository |
| collection | Online Access |
| description | Background: The influence of intraluminal thrombus (ILT) on the proteolytic environment within the wall of an abdominal aortic aneurysm (AAA) is unknown. This is the first study to examine the correlation between ILT thickness and the levels of matrix metalloproteinases (MMPs) and their natural inhibitors (tissue inhibitors of matrix metalloproteinases [TIMPs]) within the
adjacent AAA wall.
Methods: Thirty-five patients undergoing elective repair of AAAs were studied. A single full thickness infrarenal aortic sample was obtained uniformly from the arteriotomy site from each patient. All samples were snap frozen and analyzed for total and active MMP 2, 8, and 9 and
TIMP 1 and 2. Thrombus thickness at the specimen site was measured on the preoperative contrast computed tomographic angiograms.
Results: There was a statistically significant correlation between ILT thickness, concentration of TIMP 1, and active concentration of MMP 9. MMP 2 (active and total) and TIMP 2 demonstrated a positive correlation with ILT thickness, although not statistically significant.
Conclusion: In this novel study, we found a significant positive correlation of ILT thickness with active MMP 9 and TIMP 1 concentration in the adjacent AAA wall, and this may have implications for AAA expansion and eventual rupture. |
| first_indexed | 2025-11-14T16:50:13Z |
| format | Article |
| id | iium-59158 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:50:13Z |
| publishDate | 2012 |
| publisher | Elsevier |
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| repository_type | Digital Repository |
| spelling | iium-591582018-01-12T00:59:27Z http://irep.iium.edu.my/59158/ Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms Khan, J. A. Abdul Rahman, Mohd Norhisham Azmi Mazari, F. A. K. Shahin, Y Smith, G Madden, L Fagan, M. J. Greenman, J McCollum, P. T. Chetter, I. C. RD Surgery Background: The influence of intraluminal thrombus (ILT) on the proteolytic environment within the wall of an abdominal aortic aneurysm (AAA) is unknown. This is the first study to examine the correlation between ILT thickness and the levels of matrix metalloproteinases (MMPs) and their natural inhibitors (tissue inhibitors of matrix metalloproteinases [TIMPs]) within the adjacent AAA wall. Methods: Thirty-five patients undergoing elective repair of AAAs were studied. A single full thickness infrarenal aortic sample was obtained uniformly from the arteriotomy site from each patient. All samples were snap frozen and analyzed for total and active MMP 2, 8, and 9 and TIMP 1 and 2. Thrombus thickness at the specimen site was measured on the preoperative contrast computed tomographic angiograms. Results: There was a statistically significant correlation between ILT thickness, concentration of TIMP 1, and active concentration of MMP 9. MMP 2 (active and total) and TIMP 2 demonstrated a positive correlation with ILT thickness, although not statistically significant. Conclusion: In this novel study, we found a significant positive correlation of ILT thickness with active MMP 9 and TIMP 1 concentration in the adjacent AAA wall, and this may have implications for AAA expansion and eventual rupture. Elsevier 2012-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/59158/1/Intraluminal%20thrombus%20has%20a%20selective%20influence%20on%20matrix%20metalloproteinases%20and%20their%20inhibitors%20%28tissue%20inhibitors%20of%20matrix%20metalloproteinases%29%20in%20the%20wall%20of%20abdomin.pdf Khan, J. A. and Abdul Rahman, Mohd Norhisham Azmi and Mazari, F. A. K. and Shahin, Y and Smith, G and Madden, L and Fagan, M. J. and Greenman, J and McCollum, P. T. and Chetter, I. C. (2012) Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms. Annals of Vascular Surgery, 26 (3). pp. 322-329. ISSN 0890-5096 E-ISSN 1615-5947 http://www.annalsofvascularsurgery.com/ 10.1016/j.avsg.2011.08.015 |
| spellingShingle | RD Surgery Khan, J. A. Abdul Rahman, Mohd Norhisham Azmi Mazari, F. A. K. Shahin, Y Smith, G Madden, L Fagan, M. J. Greenman, J McCollum, P. T. Chetter, I. C. Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms |
| title | Intraluminal Thrombus has a selective
Influence on Matrix Metalloproteinases and
Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms |
| title_full | Intraluminal Thrombus has a selective
Influence on Matrix Metalloproteinases and
Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms |
| title_fullStr | Intraluminal Thrombus has a selective
Influence on Matrix Metalloproteinases and
Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms |
| title_full_unstemmed | Intraluminal Thrombus has a selective
Influence on Matrix Metalloproteinases and
Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms |
| title_short | Intraluminal Thrombus has a selective
Influence on Matrix Metalloproteinases and
Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms |
| title_sort | intraluminal thrombus has a selective
influence on matrix metalloproteinases and
their inhibitors (tissue inhibitors of matrix metalloproteinases) in the wall of abdominal aortic aneurysms |
| topic | RD Surgery |
| url | http://irep.iium.edu.my/59158/ http://irep.iium.edu.my/59158/ http://irep.iium.edu.my/59158/ http://irep.iium.edu.my/59158/1/Intraluminal%20thrombus%20has%20a%20selective%20influence%20on%20matrix%20metalloproteinases%20and%20their%20inhibitors%20%28tissue%20inhibitors%20of%20matrix%20metalloproteinases%29%20in%20the%20wall%20of%20abdomin.pdf |