Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate
This study investigate the effect of cooling rates on mefenamic acid crystallisation in ethyl acetate. The cooling rate was varied from 0.2 to 5 °C/min. The in-line conductivity system and turbidity system were employed to detect the onset of the crystallization process. The crystals produced wer...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Proceeding Paper |
| Language: | English English English |
| Published: |
IOP Publishing
2017
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/58987/ http://irep.iium.edu.my/58987/1/58987-Effect%20of%20Cooling%20Rates%20on%20Shape-SCOPUS.pdf http://irep.iium.edu.my/58987/2/58987-Effect%20of%20Cooling%20Rates%20on%20Shape%20and%20Crystal%20Size.pdf http://irep.iium.edu.my/58987/13/58987%20Effect%20of%20Cooling%20Rates%20on%20Shape%20WOS.pdf |
| _version_ | 1848785220033052672 |
|---|---|
| author | Abdul Mudalip, S. K. Adam, Fatmawati Jamal, Parveen Abu Bakar, Mohd Rushdi Amran, Nur Amelia Sulaiman, Siti Zubaidah Che Man, Rohaida Mohd Arshad, Z.I. Shaarani, Shalyda Md |
| author_facet | Abdul Mudalip, S. K. Adam, Fatmawati Jamal, Parveen Abu Bakar, Mohd Rushdi Amran, Nur Amelia Sulaiman, Siti Zubaidah Che Man, Rohaida Mohd Arshad, Z.I. Shaarani, Shalyda Md |
| author_sort | Abdul Mudalip, S. K. |
| building | IIUM Repository |
| collection | Online Access |
| description | This study investigate the effect of cooling rates on mefenamic acid crystallisation in
ethyl acetate. The cooling rate was varied from 0.2 to 5 °C/min. The in-line conductivity
system and turbidity system were employed to detect the onset of the crystallization process.
The crystals produced were analysed using optical microscopy and Fourier transform infrared
spectroscopy (FTIR). It was found that the crystals produced at different cooling rates were
needle-like and exhibit polymorphic form type I. However, the aspect ratio and crystal size
distributions were varied with the increased of cooling rate. A high crystals aspect ratio and
narrower CSD (100−900 μm) was obtained at cooling rate of 0.5 °C/min. Thus, can be
suggested as the most suitable cooling rate for crystallization of mefenamic acid in ethyl
acetate. |
| first_indexed | 2025-11-14T16:49:40Z |
| format | Proceeding Paper |
| id | iium-58987 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T16:49:40Z |
| publishDate | 2017 |
| publisher | IOP Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-589872019-08-17T08:16:31Z http://irep.iium.edu.my/58987/ Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate Abdul Mudalip, S. K. Adam, Fatmawati Jamal, Parveen Abu Bakar, Mohd Rushdi Amran, Nur Amelia Sulaiman, Siti Zubaidah Che Man, Rohaida Mohd Arshad, Z.I. Shaarani, Shalyda Md T Technology (General) This study investigate the effect of cooling rates on mefenamic acid crystallisation in ethyl acetate. The cooling rate was varied from 0.2 to 5 °C/min. The in-line conductivity system and turbidity system were employed to detect the onset of the crystallization process. The crystals produced were analysed using optical microscopy and Fourier transform infrared spectroscopy (FTIR). It was found that the crystals produced at different cooling rates were needle-like and exhibit polymorphic form type I. However, the aspect ratio and crystal size distributions were varied with the increased of cooling rate. A high crystals aspect ratio and narrower CSD (100−900 μm) was obtained at cooling rate of 0.5 °C/min. Thus, can be suggested as the most suitable cooling rate for crystallization of mefenamic acid in ethyl acetate. IOP Publishing 2017-06-09 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/58987/1/58987-Effect%20of%20Cooling%20Rates%20on%20Shape-SCOPUS.pdf application/pdf en http://irep.iium.edu.my/58987/2/58987-Effect%20of%20Cooling%20Rates%20on%20Shape%20and%20Crystal%20Size.pdf application/pdf en http://irep.iium.edu.my/58987/13/58987%20Effect%20of%20Cooling%20Rates%20on%20Shape%20WOS.pdf Abdul Mudalip, S. K. and Adam, Fatmawati and Jamal, Parveen and Abu Bakar, Mohd Rushdi and Amran, Nur Amelia and Sulaiman, Siti Zubaidah and Che Man, Rohaida and Mohd Arshad, Z.I. and Shaarani, Shalyda Md (2017) Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate. In: The 2nd International Conference on Materials Engineering and Nanotechnology (ICMEN2017), 12th-14th May 2017, Kuala Lumpur, Malaysia. http://iopscience.iop.org/article/10.1088/1757-899X/205/1/012025/pdf 10.1088/1757-899X/205/1/012025 |
| spellingShingle | T Technology (General) Abdul Mudalip, S. K. Adam, Fatmawati Jamal, Parveen Abu Bakar, Mohd Rushdi Amran, Nur Amelia Sulaiman, Siti Zubaidah Che Man, Rohaida Mohd Arshad, Z.I. Shaarani, Shalyda Md Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate |
| title | Effect of cooling rates on shape and crystal size
distributions of mefenamic acid polymorph in
ethyl acetate |
| title_full | Effect of cooling rates on shape and crystal size
distributions of mefenamic acid polymorph in
ethyl acetate |
| title_fullStr | Effect of cooling rates on shape and crystal size
distributions of mefenamic acid polymorph in
ethyl acetate |
| title_full_unstemmed | Effect of cooling rates on shape and crystal size
distributions of mefenamic acid polymorph in
ethyl acetate |
| title_short | Effect of cooling rates on shape and crystal size
distributions of mefenamic acid polymorph in
ethyl acetate |
| title_sort | effect of cooling rates on shape and crystal size
distributions of mefenamic acid polymorph in
ethyl acetate |
| topic | T Technology (General) |
| url | http://irep.iium.edu.my/58987/ http://irep.iium.edu.my/58987/ http://irep.iium.edu.my/58987/ http://irep.iium.edu.my/58987/1/58987-Effect%20of%20Cooling%20Rates%20on%20Shape-SCOPUS.pdf http://irep.iium.edu.my/58987/2/58987-Effect%20of%20Cooling%20Rates%20on%20Shape%20and%20Crystal%20Size.pdf http://irep.iium.edu.my/58987/13/58987%20Effect%20of%20Cooling%20Rates%20on%20Shape%20WOS.pdf |