Genetic underpinnings in Alzheimer’s disease – A review
In this review, we discuss the genetic etiologies of Alzheimer’s disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-mediated genes according to their single nucleotide polymorp...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Walter de Gruyter GmbH
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/58623/ http://irep.iium.edu.my/58623/12/58623_Genetic%20underpinnings%20in%20Alzheimer%27s%20disease.pdf http://irep.iium.edu.my/58623/7/Genetic%20underpinnings%20in%20Alzheimer%27s%20disease%20--%20%20A%20review.pdf |
| _version_ | 1848785150290165760 |
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| author | Moustafa, Ahmed A. Hassan, Mubashir Hewedi, Doaa H. Hewedi, Iman Garami, Julia K. Al Ashwal, Hany Zaki, Nazar Seo, Sung-Yum Cutsuridis, Vassilis Angulo, Sergio L. Natesh, Joman Y. Herzallah, Mohammad M. Frydecka, Dorota Misiak, Błażej Salama, Mohamed Mohamed, Wael Mohamed Yousef El Haj, Mohamad Hornberger, Michael |
| author_facet | Moustafa, Ahmed A. Hassan, Mubashir Hewedi, Doaa H. Hewedi, Iman Garami, Julia K. Al Ashwal, Hany Zaki, Nazar Seo, Sung-Yum Cutsuridis, Vassilis Angulo, Sergio L. Natesh, Joman Y. Herzallah, Mohammad M. Frydecka, Dorota Misiak, Błażej Salama, Mohamed Mohamed, Wael Mohamed Yousef El Haj, Mohamad Hornberger, Michael |
| author_sort | Moustafa, Ahmed A. |
| building | IIUM Repository |
| collection | Online Access |
| description | In this review, we discuss the genetic etiologies
of Alzheimer’s disease (AD). Furthermore, we review
genetic links to protein signaling pathways as novel
pharmacological targets to treat AD. Moreover, we also
discuss the clumps of AD-mediated genes according to
their single nucleotide polymorphism mutations. Rigorous
data mining approaches justified the significant role
of genes in AD prevalence. Pedigree analysis and twin
studies suggest that genetic components are part of the
etiology, rather than only being risk factors for AD. The
first autosomal dominant mutation in the amyloid precursor
protein (APP) gene was described in 1991. Later, AD
was also associated with mutated early-onset (presenilin
1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E,
ApoE) genes. Genome-wide association and linkage analysis
studies with identified multiple genomic areas have
implications for the treatment of AD. We conclude this
review with future directions and clinical implications of
genetic research in AD. |
| first_indexed | 2025-11-14T16:48:34Z |
| format | Article |
| id | iium-58623 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:48:34Z |
| publishDate | 2017 |
| publisher | Walter de Gruyter GmbH |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-586232018-04-27T09:18:41Z http://irep.iium.edu.my/58623/ Genetic underpinnings in Alzheimer’s disease – A review Moustafa, Ahmed A. Hassan, Mubashir Hewedi, Doaa H. Hewedi, Iman Garami, Julia K. Al Ashwal, Hany Zaki, Nazar Seo, Sung-Yum Cutsuridis, Vassilis Angulo, Sergio L. Natesh, Joman Y. Herzallah, Mohammad M. Frydecka, Dorota Misiak, Błażej Salama, Mohamed Mohamed, Wael Mohamed Yousef El Haj, Mohamad Hornberger, Michael R Medicine (General) In this review, we discuss the genetic etiologies of Alzheimer’s disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-mediated genes according to their single nucleotide polymorphism mutations. Rigorous data mining approaches justified the significant role of genes in AD prevalence. Pedigree analysis and twin studies suggest that genetic components are part of the etiology, rather than only being risk factors for AD. The first autosomal dominant mutation in the amyloid precursor protein (APP) gene was described in 1991. Later, AD was also associated with mutated early-onset (presenilin 1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E, ApoE) genes. Genome-wide association and linkage analysis studies with identified multiple genomic areas have implications for the treatment of AD. We conclude this review with future directions and clinical implications of genetic research in AD. Walter de Gruyter GmbH 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58623/12/58623_Genetic%20underpinnings%20in%20Alzheimer%27s%20disease.pdf application/pdf en http://irep.iium.edu.my/58623/7/Genetic%20underpinnings%20in%20Alzheimer%27s%20disease%20--%20%20A%20review.pdf Moustafa, Ahmed A. and Hassan, Mubashir and Hewedi, Doaa H. and Hewedi, Iman and Garami, Julia K. and Al Ashwal, Hany and Zaki, Nazar and Seo, Sung-Yum and Cutsuridis, Vassilis and Angulo, Sergio L. and Natesh, Joman Y. and Herzallah, Mohammad M. and Frydecka, Dorota and Misiak, Błażej and Salama, Mohamed and Mohamed, Wael Mohamed Yousef and El Haj, Mohamad and Hornberger, Michael (2017) Genetic underpinnings in Alzheimer’s disease – A review. Reviews in the Neurosciences, 29 (1). pp. 21-38. ISSN 0334-1763 https://www.degruyter.com/view/j/revneuro.ahead-of-print/revneuro-2017-0036/revneuro-2017-0036.xml?format=INT 10.1515/revneuro-2017-0036 |
| spellingShingle | R Medicine (General) Moustafa, Ahmed A. Hassan, Mubashir Hewedi, Doaa H. Hewedi, Iman Garami, Julia K. Al Ashwal, Hany Zaki, Nazar Seo, Sung-Yum Cutsuridis, Vassilis Angulo, Sergio L. Natesh, Joman Y. Herzallah, Mohammad M. Frydecka, Dorota Misiak, Błażej Salama, Mohamed Mohamed, Wael Mohamed Yousef El Haj, Mohamad Hornberger, Michael Genetic underpinnings in Alzheimer’s disease – A review |
| title | Genetic underpinnings in Alzheimer’s disease –
A review |
| title_full | Genetic underpinnings in Alzheimer’s disease –
A review |
| title_fullStr | Genetic underpinnings in Alzheimer’s disease –
A review |
| title_full_unstemmed | Genetic underpinnings in Alzheimer’s disease –
A review |
| title_short | Genetic underpinnings in Alzheimer’s disease –
A review |
| title_sort | genetic underpinnings in alzheimer’s disease –
a review |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/58623/ http://irep.iium.edu.my/58623/ http://irep.iium.edu.my/58623/ http://irep.iium.edu.my/58623/12/58623_Genetic%20underpinnings%20in%20Alzheimer%27s%20disease.pdf http://irep.iium.edu.my/58623/7/Genetic%20underpinnings%20in%20Alzheimer%27s%20disease%20--%20%20A%20review.pdf |