Synthesize and characterization of putrescine sulfur analogues
Cancer is a disease which has high motility rate worldwide. The current treatment has a high potential to kill cancer cells, however it is lacking of specificity and therefore cause the side effects in normal cells. The alternate pathway has been explored including targeting to cancer cells via pol...
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| Format: | Article |
| Language: | English |
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Universiti Teknologi MARA Cawangan Pulau Pinang
2017
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| Online Access: | http://irep.iium.edu.my/58120/ http://irep.iium.edu.my/58120/1/ARTICLE%20ESTEEM%20JOURNAL.pdf |
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| author | Sahabudin, Adzly Hairee How, Fiona Ni Foong Abdul Ghani, Radiah |
| author_facet | Sahabudin, Adzly Hairee How, Fiona Ni Foong Abdul Ghani, Radiah |
| author_sort | Sahabudin, Adzly Hairee |
| building | IIUM Repository |
| collection | Online Access |
| description | Cancer is a disease which has high motility rate worldwide. The current treatment has a high potential to kill cancer cells, however it is lacking of specificity and therefore cause the side effects in normal cells. The alternate
pathway has been explored including targeting to cancer cells via polyamine transport system (PTS). The PTS activity is highly upregulated in cancer cells compared to normal cells. In this study, one of the polyamines called
putrescine was being exploited to be a vector for sulphur. This putrescinesulphur analogues were synthesized using two different methods. The synthesized product was later characterized using various physicochemical techniques such as gas-chromatography and Fourier transformed-infrared
spectroscopy for structural determination. Several putrescine-sulphur analogue was succesfully synthesis with the expected structures. |
| first_indexed | 2025-11-14T16:47:02Z |
| format | Article |
| id | iium-58120 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:47:02Z |
| publishDate | 2017 |
| publisher | Universiti Teknologi MARA Cawangan Pulau Pinang |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-581202017-08-22T08:00:25Z http://irep.iium.edu.my/58120/ Synthesize and characterization of putrescine sulfur analogues Sahabudin, Adzly Hairee How, Fiona Ni Foong Abdul Ghani, Radiah QD Chemistry RM Therapeutics. Pharmacology Cancer is a disease which has high motility rate worldwide. The current treatment has a high potential to kill cancer cells, however it is lacking of specificity and therefore cause the side effects in normal cells. The alternate pathway has been explored including targeting to cancer cells via polyamine transport system (PTS). The PTS activity is highly upregulated in cancer cells compared to normal cells. In this study, one of the polyamines called putrescine was being exploited to be a vector for sulphur. This putrescinesulphur analogues were synthesized using two different methods. The synthesized product was later characterized using various physicochemical techniques such as gas-chromatography and Fourier transformed-infrared spectroscopy for structural determination. Several putrescine-sulphur analogue was succesfully synthesis with the expected structures. Universiti Teknologi MARA Cawangan Pulau Pinang 2017-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58120/1/ARTICLE%20ESTEEM%20JOURNAL.pdf Sahabudin, Adzly Hairee and How, Fiona Ni Foong and Abdul Ghani, Radiah (2017) Synthesize and characterization of putrescine sulfur analogues. ESTEEM Academic Journal, 13 (Special Issue). pp. 91-97. ISSN 1675-7939 E-ISSN 2289-4934 http://uppp.uitm.edu.my/images/doc/ESTEEM_pdf_format/vol13specialaugust/orc120.pdf |
| spellingShingle | QD Chemistry RM Therapeutics. Pharmacology Sahabudin, Adzly Hairee How, Fiona Ni Foong Abdul Ghani, Radiah Synthesize and characterization of putrescine sulfur analogues |
| title | Synthesize and characterization of putrescine sulfur analogues |
| title_full | Synthesize and characterization of putrescine sulfur analogues |
| title_fullStr | Synthesize and characterization of putrescine sulfur analogues |
| title_full_unstemmed | Synthesize and characterization of putrescine sulfur analogues |
| title_short | Synthesize and characterization of putrescine sulfur analogues |
| title_sort | synthesize and characterization of putrescine sulfur analogues |
| topic | QD Chemistry RM Therapeutics. Pharmacology |
| url | http://irep.iium.edu.my/58120/ http://irep.iium.edu.my/58120/ http://irep.iium.edu.my/58120/1/ARTICLE%20ESTEEM%20JOURNAL.pdf |