Male infertility: the effect of natural antioxidants and phytocompounds on seminal oxidative stress
Defective sperm function has been identified as the most common cause of infertility. The objective of this study was to review recent findings on the effects of various antioxidants on male fertility. High amounts of poly unsaturated fatty acid are found in the mammalian spermatozoa membranes, thereb...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2017
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| Online Access: | http://irep.iium.edu.my/57822/ http://irep.iium.edu.my/57822/1/Male%20Infertility-%20The%20Effect%20of%20Natural%20Antioxidants.pdf |
| _version_ | 1848785003221090304 |
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| author | Adewoyin, Malik Ibrahim, Muhammad Roszaman, Ramli Md Isa, Muhammad Lokman Mat Alewi, Nur Aizura Abdul Wafa, Ainin Azwani Anuar, Mohd Nur Nasyriq |
| author_facet | Adewoyin, Malik Ibrahim, Muhammad Roszaman, Ramli Md Isa, Muhammad Lokman Mat Alewi, Nur Aizura Abdul Wafa, Ainin Azwani Anuar, Mohd Nur Nasyriq |
| author_sort | Adewoyin, Malik |
| building | IIUM Repository |
| collection | Online Access |
| description | Defective sperm function has been identified as the most common cause of infertility. The objective of this study was to review recent findings on the effects of various antioxidants on male fertility. High amounts of poly unsaturated fatty acid are found in the mammalian spermatozoa membranes, thereby making them susceptible to lipid peroxidation. Although, free radicals and reactive oxygen species (ROS) play major roles in reproduction, they are strongly associated with oxidativestress. Furthermore,factorssuchasobesity,inflammation,pollutantsandcigarettesmoking are negatively correlated with spermatogenesis. Endogenous antioxidants system exists to mediate these damages. In a normal physiological state, the seminal plasma contains antioxidant enzyme mechanism that is capable of quenching these ROS as well as protecting the spermatozoa against any likely damage. However, high level of ROS triggered by inflammatory cells and oxidation of fatty acidinobesesubjectsmaydownplayantioxidantmechanismresultinginoxidativestress. Evaluation of such oxidative stress is the first step in the treatment of male infertility through administration of suitable antioxidant. Notably, antioxidant such as vitamin E and C, carotenoids and carnitine have been found beneficial in restoring a balance between ROS generation and scavenging activities. There are emerging evidences that herbal products can also boost male reproductive functions. Nonetheless, a good lifestyle, regular exercise, avoidance of stress and observing safety rules at work are habits that can reverse male infertility. |
| first_indexed | 2025-11-14T16:46:14Z |
| format | Article |
| id | iium-57822 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:46:14Z |
| publishDate | 2017 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-578222023-11-21T01:35:56Z http://irep.iium.edu.my/57822/ Male infertility: the effect of natural antioxidants and phytocompounds on seminal oxidative stress Adewoyin, Malik Ibrahim, Muhammad Roszaman, Ramli Md Isa, Muhammad Lokman Mat Alewi, Nur Aizura Abdul Wafa, Ainin Azwani Anuar, Mohd Nur Nasyriq RM214 Diet therapy. Diet and dietectics in disease Defective sperm function has been identified as the most common cause of infertility. The objective of this study was to review recent findings on the effects of various antioxidants on male fertility. High amounts of poly unsaturated fatty acid are found in the mammalian spermatozoa membranes, thereby making them susceptible to lipid peroxidation. Although, free radicals and reactive oxygen species (ROS) play major roles in reproduction, they are strongly associated with oxidativestress. Furthermore,factorssuchasobesity,inflammation,pollutantsandcigarettesmoking are negatively correlated with spermatogenesis. Endogenous antioxidants system exists to mediate these damages. In a normal physiological state, the seminal plasma contains antioxidant enzyme mechanism that is capable of quenching these ROS as well as protecting the spermatozoa against any likely damage. However, high level of ROS triggered by inflammatory cells and oxidation of fatty acidinobesesubjectsmaydownplayantioxidantmechanismresultinginoxidativestress. Evaluation of such oxidative stress is the first step in the treatment of male infertility through administration of suitable antioxidant. Notably, antioxidant such as vitamin E and C, carotenoids and carnitine have been found beneficial in restoring a balance between ROS generation and scavenging activities. There are emerging evidences that herbal products can also boost male reproductive functions. Nonetheless, a good lifestyle, regular exercise, avoidance of stress and observing safety rules at work are habits that can reverse male infertility. MDPI 2017-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57822/1/Male%20Infertility-%20The%20Effect%20of%20Natural%20Antioxidants.pdf Adewoyin, Malik and Ibrahim, Muhammad and Roszaman, Ramli and Md Isa, Muhammad Lokman and Mat Alewi, Nur Aizura and Abdul Wafa, Ainin Azwani and Anuar, Mohd Nur Nasyriq (2017) Male infertility: the effect of natural antioxidants and phytocompounds on seminal oxidative stress. Diseases, 5 (1). pp. 1-26. ISSN 2079-9721 http://www.mdpi.com/2079-9721/5/1/9 10.3390/diseases5010009 |
| spellingShingle | RM214 Diet therapy. Diet and dietectics in disease Adewoyin, Malik Ibrahim, Muhammad Roszaman, Ramli Md Isa, Muhammad Lokman Mat Alewi, Nur Aizura Abdul Wafa, Ainin Azwani Anuar, Mohd Nur Nasyriq Male infertility: the effect of natural antioxidants and phytocompounds on seminal oxidative stress |
| title | Male infertility: the effect of natural antioxidants and phytocompounds on seminal oxidative stress |
| title_full | Male infertility: the effect of natural antioxidants and phytocompounds on seminal oxidative stress |
| title_fullStr | Male infertility: the effect of natural antioxidants and phytocompounds on seminal oxidative stress |
| title_full_unstemmed | Male infertility: the effect of natural antioxidants and phytocompounds on seminal oxidative stress |
| title_short | Male infertility: the effect of natural antioxidants and phytocompounds on seminal oxidative stress |
| title_sort | male infertility: the effect of natural antioxidants and phytocompounds on seminal oxidative stress |
| topic | RM214 Diet therapy. Diet and dietectics in disease |
| url | http://irep.iium.edu.my/57822/ http://irep.iium.edu.my/57822/ http://irep.iium.edu.my/57822/ http://irep.iium.edu.my/57822/1/Male%20Infertility-%20The%20Effect%20of%20Natural%20Antioxidants.pdf |