Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII

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Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII

We report a series of novel metanilamide-based derivatives 3a–q bearing the 2-mercapto-4-oxo-4H-quinazolin-3-yl moiety as tail. All compounds were synthesized by means of straightforward condensation procedures and were investigated in vitro for their inhibition potency against the human (h) carboni...

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Bibliographic Details
Main Authors:	Bozdag, Murat, Alafeefy, Ahmed Mahmoud, Altamimi, Abdul Malik, Carta, Fabrizio, Supuran,, Claudiu T., Vullo, Daniela
Format:	Article
Language:	English English English
Published:	Elsevier Ltd 2017
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/57250/ http://irep.iium.edu.my/57250/3/57250_Synthesis%20of%20new%203-%282-mercapto_WOS.pdf http://irep.iium.edu.my/57250/19/57250_Synthesis%20of%20new%203-%282-mercapto-4-oxo-4H-quinazolin-3-yl%29.pdf http://irep.iium.edu.my/57250/25/57250_Synthesis%20of%20new%203-%282-mercapto-4-oxo-4H-quinazolin-3-yl%29-benzenesulfonamides_SCOPUS.pdf

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