Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response
The present study focused on the preparation of nanohydroxyapatite (nHA)-coated hydroxyethyl cellulose/polyvinyl alcohol (HEC/PVA) nanofibrous scaffolds for bone tissue engineering application. The electrospun HEC/PVA scaffolds were mineralized via alternate soaking process. FESEM revealed that the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English English English |
| Published: |
Taylor & Francis Online
2017
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/57199/ http://irep.iium.edu.my/57199/2/57199_Nanohydroxyapatite-coated_SCOPUS.pdf http://irep.iium.edu.my/57199/3/57199_Nanohydroxyapatite-coated_WOS.pdf http://irep.iium.edu.my/57199/19/57199_Nanohydroxyapatite-coated%20hydroxyethyl.pdf |
| _version_ | 1848784884453081088 |
|---|---|
| author | Chahal, Sugandha Jahir Hussain, Fathima Shahitha Mohd Yusoff, Mashitah Abdull Rasad, Mohammad Syaiful Bahari Kumar, Anuj |
| author_facet | Chahal, Sugandha Jahir Hussain, Fathima Shahitha Mohd Yusoff, Mashitah Abdull Rasad, Mohammad Syaiful Bahari Kumar, Anuj |
| author_sort | Chahal, Sugandha |
| building | IIUM Repository |
| collection | Online Access |
| description | The present study focused on the preparation of nanohydroxyapatite (nHA)-coated hydroxyethyl cellulose/polyvinyl alcohol (HEC/PVA) nanofibrous scaffolds for bone tissue engineering application. The electrospun HEC/PVA scaffolds were mineralized via alternate soaking process. FESEM revealed that the nHA was formed uniformly over the nanofibers. The nHA mineralization enhanced the tensile strength and reduced the elongation at breakage of scaffolds. The wettability of the nanofibrous scaffolds was significantly improved. The in vitro biocompatibility of scaffolds was evaluated with human osteosarcoma cells. nHA-coated scaffolds had a favorable effect on the proliferation and differentiation of osteosarcoma cell and could be a potential candidate for bone regeneration. |
| first_indexed | 2025-11-14T16:44:20Z |
| format | Article |
| id | iium-57199 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T16:44:20Z |
| publishDate | 2017 |
| publisher | Taylor & Francis Online |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-571992022-06-08T07:39:52Z http://irep.iium.edu.my/57199/ Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response Chahal, Sugandha Jahir Hussain, Fathima Shahitha Mohd Yusoff, Mashitah Abdull Rasad, Mohammad Syaiful Bahari Kumar, Anuj Q Science (General) The present study focused on the preparation of nanohydroxyapatite (nHA)-coated hydroxyethyl cellulose/polyvinyl alcohol (HEC/PVA) nanofibrous scaffolds for bone tissue engineering application. The electrospun HEC/PVA scaffolds were mineralized via alternate soaking process. FESEM revealed that the nHA was formed uniformly over the nanofibers. The nHA mineralization enhanced the tensile strength and reduced the elongation at breakage of scaffolds. The wettability of the nanofibrous scaffolds was significantly improved. The in vitro biocompatibility of scaffolds was evaluated with human osteosarcoma cells. nHA-coated scaffolds had a favorable effect on the proliferation and differentiation of osteosarcoma cell and could be a potential candidate for bone regeneration. Taylor & Francis Online 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/57199/2/57199_Nanohydroxyapatite-coated_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/57199/3/57199_Nanohydroxyapatite-coated_WOS.pdf application/pdf en http://irep.iium.edu.my/57199/19/57199_Nanohydroxyapatite-coated%20hydroxyethyl.pdf Chahal, Sugandha and Jahir Hussain, Fathima Shahitha and Mohd Yusoff, Mashitah and Abdull Rasad, Mohammad Syaiful Bahari and Kumar, Anuj (2017) Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response. International Journal of Polymeric Materials and Polymeric Biomaterials, 66 (3). pp. 115-122. ISSN 0091-4037 E-ISSN 1563-535X http://www.tandfonline.com/doi/abs/10.1080/00914037.2016.1190926?journalCode=gpom20 |
| spellingShingle | Q Science (General) Chahal, Sugandha Jahir Hussain, Fathima Shahitha Mohd Yusoff, Mashitah Abdull Rasad, Mohammad Syaiful Bahari Kumar, Anuj Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response |
| title | Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response |
| title_full | Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response |
| title_fullStr | Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response |
| title_full_unstemmed | Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response |
| title_short | Nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response |
| title_sort | nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response |
| topic | Q Science (General) |
| url | http://irep.iium.edu.my/57199/ http://irep.iium.edu.my/57199/ http://irep.iium.edu.my/57199/2/57199_Nanohydroxyapatite-coated_SCOPUS.pdf http://irep.iium.edu.my/57199/3/57199_Nanohydroxyapatite-coated_WOS.pdf http://irep.iium.edu.my/57199/19/57199_Nanohydroxyapatite-coated%20hydroxyethyl.pdf |