Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model
Introduction: Nigella sativa has been reported to have anti-inflammatory and anti-oxidative properties. We aimed to investigate the effects of Nigella sativa oil extract on the high fat diet (HFD) fed animal model. Methods: Thirty male Sprague-Dawley rats were used. Four groups (n=7) were fed with h...
| Main Authors: | , , , |
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| Format: | Monograph |
| Language: | English |
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2017
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| Online Access: | http://irep.iium.edu.my/57071/ http://irep.iium.edu.my/57071/1/RESEARCH%20REPORT%20IREP%20FORMAT%20DR%20ROSLINA%20latest.pdf |
| _version_ | 1848784861186228224 |
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| author | Abdul Rahim, Roslina Badaruddin, Muhammad Taufiq Ahmed, Qamar Uddin Muhammad, Siti Aeshah @ Naznin |
| author_facet | Abdul Rahim, Roslina Badaruddin, Muhammad Taufiq Ahmed, Qamar Uddin Muhammad, Siti Aeshah @ Naznin |
| author_sort | Abdul Rahim, Roslina |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction: Nigella sativa has been reported to have anti-inflammatory and anti-oxidative properties. We aimed to investigate the effects of Nigella sativa oil extract on the high fat diet (HFD) fed animal model. Methods: Thirty male Sprague-Dawley rats were used. Four groups (n=7) were fed with high fat diet (HFD) rat pellet orally for 10 weeks. The rats with HFD groups were subsequently randomly divided again into 4 groups. One group was continued with HFD while the other 3 groups were continued with the HFD in addition to Nigella sativa oil extract treatment at three different concentrations (0.5, 1 and 1.5 ml/kg/day) for another 4 weeks. Blood biochemical analysis and histological assessment of liver were subsequently performed. Results: Animals fed with HFD had increased aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, cholesterol/HDL ratio, triglyceride (TG) levels, but decreased globulin, albumin/globulin ratio and high density lipoprotein (HDL) levels. Meanwhile, HFD animals treated with Nigella sativa oil extract showed a significant increase in the globulin and HDL levels, but reduced ALP, albumin, cholesterol/HDL ratio and TG levels. Nigella sativa oil extract at the higher doses displayed much better effect. Histologically the liver in all groups exhibited micro vesicular steatosis. Conclusions: Nigella sativa oil extracts improve the dyslipidaemia in animal models with HFD. |
| first_indexed | 2025-11-14T16:43:58Z |
| format | Monograph |
| id | iium-57071 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:43:58Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-570712022-04-06T03:33:10Z http://irep.iium.edu.my/57071/ Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model Abdul Rahim, Roslina Badaruddin, Muhammad Taufiq Ahmed, Qamar Uddin Muhammad, Siti Aeshah @ Naznin QP Physiology RA Public aspects of medicine RB Pathology Introduction: Nigella sativa has been reported to have anti-inflammatory and anti-oxidative properties. We aimed to investigate the effects of Nigella sativa oil extract on the high fat diet (HFD) fed animal model. Methods: Thirty male Sprague-Dawley rats were used. Four groups (n=7) were fed with high fat diet (HFD) rat pellet orally for 10 weeks. The rats with HFD groups were subsequently randomly divided again into 4 groups. One group was continued with HFD while the other 3 groups were continued with the HFD in addition to Nigella sativa oil extract treatment at three different concentrations (0.5, 1 and 1.5 ml/kg/day) for another 4 weeks. Blood biochemical analysis and histological assessment of liver were subsequently performed. Results: Animals fed with HFD had increased aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, cholesterol/HDL ratio, triglyceride (TG) levels, but decreased globulin, albumin/globulin ratio and high density lipoprotein (HDL) levels. Meanwhile, HFD animals treated with Nigella sativa oil extract showed a significant increase in the globulin and HDL levels, but reduced ALP, albumin, cholesterol/HDL ratio and TG levels. Nigella sativa oil extract at the higher doses displayed much better effect. Histologically the liver in all groups exhibited micro vesicular steatosis. Conclusions: Nigella sativa oil extracts improve the dyslipidaemia in animal models with HFD. 2017-05-25 Monograph NonPeerReviewed application/pdf en http://irep.iium.edu.my/57071/1/RESEARCH%20REPORT%20IREP%20FORMAT%20DR%20ROSLINA%20latest.pdf Abdul Rahim, Roslina and Badaruddin, Muhammad Taufiq and Ahmed, Qamar Uddin and Muhammad, Siti Aeshah @ Naznin (2017) Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model. UNSPECIFIED. UNSPECIFIED. (Unpublished) |
| spellingShingle | QP Physiology RA Public aspects of medicine RB Pathology Abdul Rahim, Roslina Badaruddin, Muhammad Taufiq Ahmed, Qamar Uddin Muhammad, Siti Aeshah @ Naznin Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model |
| title | Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model |
| title_full | Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model |
| title_fullStr | Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model |
| title_full_unstemmed | Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model |
| title_short | Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model |
| title_sort | nigella sativa oil extracts improves dyslipidaemia in high fat diet (hfd) animal model |
| topic | QP Physiology RA Public aspects of medicine RB Pathology |
| url | http://irep.iium.edu.my/57071/ http://irep.iium.edu.my/57071/1/RESEARCH%20REPORT%20IREP%20FORMAT%20DR%20ROSLINA%20latest.pdf |