Improved dissolution, flow property and compressibility of poor soluble API by co-grinding with fine silica

QR Code

Improved dissolution, flow property and compressibility of poor soluble API by co-grinding with fine silica

Objective:The objective of this work was to enhance dissolution and tableting property of a poor soluble API which also has poor flow property. If flowability and compressibility of the API can be improved, the drug powder would be suitable to direct compression method of tableting. Methods:Ibupro...

Full description

Bibliographic Details
Main Author:	Chatterjee, Bappaditya
Format:	Proceeding Paper
Language:	English
Published:	2017
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/56692/ http://irep.iium.edu.my/56692/11/iccps_complete.pdf

Similar Items

Micronized carvedilol SR matrix tablet for improved dissolution
by: Chatterjee, Bappaditya
Published: (2016)

Effects of mixing ibuprofen with hydrophobic and hydrophilic colloidal silicon dioxide on powder flow property and solubility: a comparative study
by: Ruzaidi, Ahmad Fahmi, et al.
Published: (2015)

Polymer selection for nisoldipine solid dispersion to enhance solubility
by: Kyaw Oo, May, et al.
Published: (2015)

Pharmaceutical application of solid dispersion technology in improving solubility of poorly soluble drugd : a review
by: Mandal, Uttam Kumar
Published: (2011)

Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine
by: Chitneni , Mallikarjun
Published: (2010)

Manufacturing operations
by: Chatterjee, Bappaditya
Published: (2015)

Nose to brain drug delivery: a recent update
by: Chatterjee, Bappaditya
Published: (2017)

Glidant effect of hydrophobic and hydrophilic nanosilica on a cohesivepowder: comparison of different flow characterization techniques
by: Ruzaidi, Fahmi Ahmad, et al.
Published: (2017)

Solubility and dissolution thermodynamic data of mefenamic acid crystals in different classes of Organic solvents
by: Abdul Mudalip, Siti Kholijah, et al.
Published: (2013)

Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs
by: Sengupta, Pinaki, et al.
Published: (2017)

Non-gelatin or vegetative sourced capsule: miles crossed and miles to go
by: Chatterjee, Bappaditya, et al.
Published: (2016)

iSalic - 25% methyl salicylate ointment, 3% camphor and 3% menthol
by: Mohamed, Farahidah, et al.
Published: (2020)

Development of an appropriate and robust dissolution method for solid dosage forms
by: Mandal, Uttam Kumar
Published: (2011)

iKool ointment - 10% eucalyptus oil, 5% peppermint oil, 5% menthol, 5% camphor
by: Mohamed, Farahidah, et al.
Published: (2020)

Improved solubility of telmisartan by using freeze-dried solid dispersion method
by: Aljapairai, Khater Ahmed Saeed, et al.
Published: (2017)

Current regulatory requirements and practical approaches for stability analysis of pharmaceutical products: a comprehensive review
by: Sengupta, Pinaki Ranjan, et al.
Published: (2018)

Advanced characterizations of nanoparticles for drug delivery: Investigating their existence through the techniques used in their evaluations
by: Mahmood, Sayed, et al.
Published: (2016)

Temizsol hand sanitizer solution containing chlorhexidine gluconate and ethanol
by: Mohamed, Farahidah, et al.
Published: (2020)

Temizsol hand sanitizer solution containing chlorhexidine gluconate and ethanol
by: Mohamed, Farahidah, et al.
Published: (2020)

Transdermal delivery of raloxifene HCl via ethosomal system: Formulation, advanced characterizations and pharmacokinetic evaluation
by: Mahmood, Syed, et al.
Published: (2018)

Polymeric behavior evaluation of PVP K30- poloxamer binary carrier for solid dispersed nisoldipine by experimental design
by: Kyaw Oo, May, et al.
Published: (2015)

Gastro-retentive drug delivery systems and their in vivo success: A recent update
by: Mandal, Uttam Kumar, et al.
Published: (2016)

A review on transdermal spray: formulation aspect
by: Mandal, Uttam Kumar, et al.
Published: (2016)

Mucoadhesive polymers and their mode of action: a recent update
by: Chatterjee, Bappaditya, et al.
Published: (2017)

Stability-indicating RP-HPLC method for simultaneous quantitation of tramadol and aceclofenac in presence of their major degradation products: Method development and validation
by: ., Md. Gousuddin, et al.
Published: (2017)

Advanced characterization of ethanolic nano lipid vesicles loaded with raloxifene HCl for transdermal drug delivery
by: Mahmood, Syed, et al.
Published: (2016)

Fast and simple gas chromatographic method for simultaneous estimation of camphor, menthol and methyl salicylate in analgesic ointment: application in stability study
by: Md Adib, Noor Adibah, et al.
Published: (2017)

Development and characterization of topical analgesic ointment - from laboratory to production scale
by: Md Adib, Noor Adibah, et al.
Published: (2016)

Development and validation of a LC- MS/MS Method for simultaneous quantitation of telmisartan and pioglitazone in rat plasma
by: Das, Arindam, et al.
Published: (2016)

Development, Validation and Pharmacokinetic Application of a Simple and Robust RP-HPLC Method for Quantitation of Raloxifene in Rat Plasma
by: Mahmood, Syed, et al.
Published: (2017)

Direct compressed tablet with melt dispersed drug particle without binder
by: Ruzaidi, Ahmad Fahmi, et al.
Published: (2017)

Development and validation of a high throughput LC–MS/MS method for simultaneous quantitation of pioglitazone and telmisartan in rat plasma and its application to a pharmacokinetic study
by: Sengupta, Pinaki, et al.
Published: (2017)

Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics
by: Win, Thazin, et al.
Published: (2017)

Fine Grinding Of Silica Via Stirred Milling
by: Mohd Za’i, Mohamad Zulhakimi Haiqal
Published: (2022)

Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion
by: Helal Uddin, A.B.M., et al.
Published: (2018)

Differential scanning calorimetric characterization of pharmaceutical powder blend uniformity in a laboratory-scale V-blender
by: Mahmood, Syed, et al.
Published: (2015)

Exploring blend uniformity of a binary mixture containing metformin Hcl and hydroxypropyl methyl cellulose by DSC
by: Hilmi, Nur Nadhirah, et al.
Published: (2015)

Exploring powder blend uniformity of a binary mixture containing metformin HCl and HPMC by differential scanning calorimetry (DSC)
by: Hilmi, Nur Nadhirah, et al.
Published: (2015)

Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route
by: Chowdhury, Hira, et al.
Published: (2017)

Microencapsulation of black seed oil in alginate beads for stability and taste masking
by: Alkhatib, Hamzeh, et al.
Published: (2020)