Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus
An antimicrobial compound has been isolated from the leaves of Glochidion superbum. The compound was determined as methyl 3, 4, 5-trihydroxybenzoate (methyl gallate), based on ultraviolet (UV), infrared (IR), nuclear magnetic resonance (NMR) and mass spectroscopy (MS) analysis. The isolated compound...
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Korean Society of Pharmacognosy
2017
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| Online Access: | http://irep.iium.edu.my/56541/ http://irep.iium.edu.my/56541/1/Nat%20Prod%20Sci%20Dahiru.pdf http://irep.iium.edu.my/56541/7/56541_Antimicrobial%20activity%20of%20methyl%20gallate_scopus.pdf |
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| author | Ahmed, Mohammed Dahiru Bakhtiar, Muhammad Taher Maimusa, Alhaji Hamusu Rezali, Mohd Fazlin Mustafa Mahmoud, Mohammed Imad Al-Deen |
| author_facet | Ahmed, Mohammed Dahiru Bakhtiar, Muhammad Taher Maimusa, Alhaji Hamusu Rezali, Mohd Fazlin Mustafa Mahmoud, Mohammed Imad Al-Deen |
| author_sort | Ahmed, Mohammed Dahiru |
| building | IIUM Repository |
| collection | Online Access |
| description | An antimicrobial compound has been isolated from the leaves of Glochidion superbum. The compound was determined as methyl 3, 4, 5-trihydroxybenzoate (methyl gallate), based on ultraviolet (UV), infrared (IR), nuclear magnetic resonance (NMR) and mass spectroscopy (MS) analysis. The isolated compound
exhibited potent antimicrobial activity against three clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) by qualitative agar disc diffusion method and quantitative broth dilution method. Agar disc diffusion was done in a dose-dependent manner for each bacterial isolate at disc potencies of 25, 50, 100, and 150 µg/disc. The zones of inhibition were on average equal to 12.27, 14.20, 15.43, and 24.17 mm respectively. The inhibition zones were compared with that of vancomycin disc at 30 µg as a reference standard. The MIC and MBC values were 50 µg/mL and 100 µg/mL respectively. The results of anti MRSA activity were analyzed using one-way ANOVA with Turkey’s HSD and Duncan test. In conclusion, methyl gallate which was isolated from G. superbum showed
the inhibition activity against methicillin resistant S. aureus |
| first_indexed | 2025-11-14T16:42:20Z |
| format | Article |
| id | iium-56541 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:42:20Z |
| publishDate | 2017 |
| publisher | Korean Society of Pharmacognosy |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-565412018-03-16T07:47:00Z http://irep.iium.edu.my/56541/ Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus Ahmed, Mohammed Dahiru Bakhtiar, Muhammad Taher Maimusa, Alhaji Hamusu Rezali, Mohd Fazlin Mustafa Mahmoud, Mohammed Imad Al-Deen RS Pharmacy and materia medica An antimicrobial compound has been isolated from the leaves of Glochidion superbum. The compound was determined as methyl 3, 4, 5-trihydroxybenzoate (methyl gallate), based on ultraviolet (UV), infrared (IR), nuclear magnetic resonance (NMR) and mass spectroscopy (MS) analysis. The isolated compound exhibited potent antimicrobial activity against three clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) by qualitative agar disc diffusion method and quantitative broth dilution method. Agar disc diffusion was done in a dose-dependent manner for each bacterial isolate at disc potencies of 25, 50, 100, and 150 µg/disc. The zones of inhibition were on average equal to 12.27, 14.20, 15.43, and 24.17 mm respectively. The inhibition zones were compared with that of vancomycin disc at 30 µg as a reference standard. The MIC and MBC values were 50 µg/mL and 100 µg/mL respectively. The results of anti MRSA activity were analyzed using one-way ANOVA with Turkey’s HSD and Duncan test. In conclusion, methyl gallate which was isolated from G. superbum showed the inhibition activity against methicillin resistant S. aureus Korean Society of Pharmacognosy 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/56541/1/Nat%20Prod%20Sci%20Dahiru.pdf application/pdf en http://irep.iium.edu.my/56541/7/56541_Antimicrobial%20activity%20of%20methyl%20gallate_scopus.pdf Ahmed, Mohammed Dahiru and Bakhtiar, Muhammad Taher and Maimusa, Alhaji Hamusu and Rezali, Mohd Fazlin and Mustafa Mahmoud, Mohammed Imad Al-Deen (2017) Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus. Natural Product Sciences, 23 (1). pp. 5-8. ISSN 1226-3907 E-ISSN 2288-9027 http://www.e-nps.or.kr/ 10.20307/nps.2017.23.1.5 |
| spellingShingle | RS Pharmacy and materia medica Ahmed, Mohammed Dahiru Bakhtiar, Muhammad Taher Maimusa, Alhaji Hamusu Rezali, Mohd Fazlin Mustafa Mahmoud, Mohammed Imad Al-Deen Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus |
| title | Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus |
| title_full | Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus |
| title_fullStr | Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus |
| title_full_unstemmed | Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus |
| title_short | Antimicrobial activity of methyl gallate isolated from the leaves of Glochidion superbum against hospital isolates of methicillin resistant Staphylococcus aureus |
| title_sort | antimicrobial activity of methyl gallate isolated from the leaves of glochidion superbum against hospital isolates of methicillin resistant staphylococcus aureus |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/56541/ http://irep.iium.edu.my/56541/ http://irep.iium.edu.my/56541/ http://irep.iium.edu.my/56541/1/Nat%20Prod%20Sci%20Dahiru.pdf http://irep.iium.edu.my/56541/7/56541_Antimicrobial%20activity%20of%20methyl%20gallate_scopus.pdf |