Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition
The tumor microenvironment (TEM) comprise of various cellular and molecular components such as fibroblasts, immune cells, bone marrow-derived inflammatory cells, endothelial cells, extracellular matrix (ECM), and signaling molecules. The complex crosstalk between TEM components and signaling pathway...
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| Format: | Proceeding Paper |
| Language: | English |
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Kulliyyah of Engineering, International Islamic University Malaysia
2016
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| Online Access: | http://irep.iium.edu.my/56373/ http://irep.iium.edu.my/56373/19/56373.pdf |
| _version_ | 1848784724235911168 |
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| author | Razak, Eliza Yusof, Faridah Ahmad Raus, Raha |
| author_facet | Razak, Eliza Yusof, Faridah Ahmad Raus, Raha |
| author_sort | Razak, Eliza |
| building | IIUM Repository |
| collection | Online Access |
| description | The tumor microenvironment (TEM) comprise of various cellular and molecular components such as fibroblasts, immune cells, bone marrow-derived inflammatory cells, endothelial cells, extracellular matrix (ECM), and signaling molecules. The complex crosstalk between TEM components and signaling pathways can give rise to tumorigenesis, progression, and angiogenesis as well as micro-metastasis and macro-metastasis. MicroRNAs (miRNAs) are small, non-coding extracellular RNAs involved in post-transcriptional regulation of gene silencing or degradation by base paring at open reading frame (ORF) region of the target mRNA. Recent advances in the miRNA field have driven to the understanding of multiple regulatory aspects concerning cancer biology. Acquisition of aberrant miRNA expression level in neoplastic tumor compared with normal tissue are promising biomarkers for cancer diagnosis. Epithelial-mesenchymal transition (EMT) is a reversible process in which neoplastic epithelial cells expressed mesenchymal phenotypes and resulting in alteration of cell autonomous mechanisms. EMT enables epithelial cells to lose their cell polarity, acquire cancer stem cell-like properties which favor tumor invasion, extravasation and metastasis. Mesenchymal–epithelial transition (MET) is the inverse process of EMT. This results in stabilization of distant metastases by permitting cancerous cells to recoup epithelial phenotypes and integrate into distant organs. Ectopic microRNA expression and disturbed signaling pathways have been associated with orchestrating EMT and MET processes. However, the exact molecular mechanisms behind oncogenic EMT and MET have remained widely elusive. This review describes the co-regulatory loops among miRNAs, target genes and important regulatory pathways involved in oncogenic EMT and MET. |
| first_indexed | 2025-11-14T16:41:48Z |
| format | Proceeding Paper |
| id | iium-56373 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:41:48Z |
| publishDate | 2016 |
| publisher | Kulliyyah of Engineering, International Islamic University Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-563732017-04-28T02:06:17Z http://irep.iium.edu.my/56373/ Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition Razak, Eliza Yusof, Faridah Ahmad Raus, Raha TA164 Bioengineering The tumor microenvironment (TEM) comprise of various cellular and molecular components such as fibroblasts, immune cells, bone marrow-derived inflammatory cells, endothelial cells, extracellular matrix (ECM), and signaling molecules. The complex crosstalk between TEM components and signaling pathways can give rise to tumorigenesis, progression, and angiogenesis as well as micro-metastasis and macro-metastasis. MicroRNAs (miRNAs) are small, non-coding extracellular RNAs involved in post-transcriptional regulation of gene silencing or degradation by base paring at open reading frame (ORF) region of the target mRNA. Recent advances in the miRNA field have driven to the understanding of multiple regulatory aspects concerning cancer biology. Acquisition of aberrant miRNA expression level in neoplastic tumor compared with normal tissue are promising biomarkers for cancer diagnosis. Epithelial-mesenchymal transition (EMT) is a reversible process in which neoplastic epithelial cells expressed mesenchymal phenotypes and resulting in alteration of cell autonomous mechanisms. EMT enables epithelial cells to lose their cell polarity, acquire cancer stem cell-like properties which favor tumor invasion, extravasation and metastasis. Mesenchymal–epithelial transition (MET) is the inverse process of EMT. This results in stabilization of distant metastases by permitting cancerous cells to recoup epithelial phenotypes and integrate into distant organs. Ectopic microRNA expression and disturbed signaling pathways have been associated with orchestrating EMT and MET processes. However, the exact molecular mechanisms behind oncogenic EMT and MET have remained widely elusive. This review describes the co-regulatory loops among miRNAs, target genes and important regulatory pathways involved in oncogenic EMT and MET. Kulliyyah of Engineering, International Islamic University Malaysia 2016 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/56373/19/56373.pdf Razak, Eliza and Yusof, Faridah and Ahmad Raus, Raha (2016) Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition. In: 4th International Conference on Biotechnology Engineering 2016 (ICBioE 2016), 25th-27th July 2016, Kuala Lumpur. http://www.iium.edu.my/icbioe/2016/ |
| spellingShingle | TA164 Bioengineering Razak, Eliza Yusof, Faridah Ahmad Raus, Raha Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition |
| title | Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition |
| title_full | Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition |
| title_fullStr | Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition |
| title_full_unstemmed | Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition |
| title_short | Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition |
| title_sort | ectopic mirna network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition |
| topic | TA164 Bioengineering |
| url | http://irep.iium.edu.my/56373/ http://irep.iium.edu.my/56373/ http://irep.iium.edu.my/56373/19/56373.pdf |