The cholesterol lowering effects of Eurycoma longifolia Jack (Tongkat Ali) root extract in male rats
Background: To investigate the effect of Eurycoma longifolia Jack root extract on serum lipids in rats. Methods: Twenty-six mature male albino Wistar rats were used in this study. A group of 18 rats were fed a high fat and high cholesterol diet for 4 weeks, after which their lipid profile was compar...
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Universitas Indonesia
2017
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| Online Access: | http://irep.iium.edu.my/56299/ http://irep.iium.edu.my/56299/1/Cholesterol%20lowering%20effects%20of%20Eurycoma%20longifolia%20jack.pdf http://irep.iium.edu.my/56299/7/56299_The%20cholesterol%20lowering%20effects%20of%20Eurycoma%20longifolia%20Jack_WOS.pdf |
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| author | Faisal, Ghasak Ghazi Abllah, Zurainie Najmuldeen, Ghazi Faisal Al-Ani, Ali Sabri Radeef |
| author_facet | Faisal, Ghasak Ghazi Abllah, Zurainie Najmuldeen, Ghazi Faisal Al-Ani, Ali Sabri Radeef |
| author_sort | Faisal, Ghasak Ghazi |
| building | IIUM Repository |
| collection | Online Access |
| description | Background: To investigate the effect of Eurycoma longifolia Jack root extract on serum lipids in rats. Methods: Twenty-six mature male albino Wistar rats were used in this study. A group of 18 rats were fed a high fat and high cholesterol diet for 4 weeks, after which their lipid profile was compared to the control group, who were kept on a normal diet. The rats were then further divided into three groups, the Cf group that continued to feed on a high fat and cholesterol diet only, and group A and group B who continued on a high fat diet with the addition of 5 mg/kg and 10 mg/kg of Eurycoma longifolia Jack root extract respectively for 4 weeks. After the 4 week period, the rat’s lipid profiles were analysed again. Results: Group A and B showed significant total cholesterol reduction when compared to the Cf group, 140 ± 7.23, 139.63 ± 7.95, 192.14 ± 8.96 mg/dL respectively (p < 0.001). The total cholesterol/HDL ratio in group A was 5 however there was a sharp increase in group B to a high-risk level of 9.2 indicating a significant drop in HDL levels. The LDL level increased significantly in both group A and B compared to the Cf group. Conclusions: Eurycoma longifolia Jack root extract is effective in lowering total cholesterol, however the dose needs to be adjusted to prevent an excessive decrease in HDL levels. |
| first_indexed | 2025-11-14T16:41:35Z |
| format | Article |
| id | iium-56299 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:41:35Z |
| publishDate | 2017 |
| publisher | Universitas Indonesia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-562992017-10-09T07:35:57Z http://irep.iium.edu.my/56299/ The cholesterol lowering effects of Eurycoma longifolia Jack (Tongkat Ali) root extract in male rats Faisal, Ghasak Ghazi Abllah, Zurainie Najmuldeen, Ghazi Faisal Al-Ani, Ali Sabri Radeef RB Pathology Background: To investigate the effect of Eurycoma longifolia Jack root extract on serum lipids in rats. Methods: Twenty-six mature male albino Wistar rats were used in this study. A group of 18 rats were fed a high fat and high cholesterol diet for 4 weeks, after which their lipid profile was compared to the control group, who were kept on a normal diet. The rats were then further divided into three groups, the Cf group that continued to feed on a high fat and cholesterol diet only, and group A and group B who continued on a high fat diet with the addition of 5 mg/kg and 10 mg/kg of Eurycoma longifolia Jack root extract respectively for 4 weeks. After the 4 week period, the rat’s lipid profiles were analysed again. Results: Group A and B showed significant total cholesterol reduction when compared to the Cf group, 140 ± 7.23, 139.63 ± 7.95, 192.14 ± 8.96 mg/dL respectively (p < 0.001). The total cholesterol/HDL ratio in group A was 5 however there was a sharp increase in group B to a high-risk level of 9.2 indicating a significant drop in HDL levels. The LDL level increased significantly in both group A and B compared to the Cf group. Conclusions: Eurycoma longifolia Jack root extract is effective in lowering total cholesterol, however the dose needs to be adjusted to prevent an excessive decrease in HDL levels. Universitas Indonesia 2017-04-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/56299/1/Cholesterol%20lowering%20effects%20of%20Eurycoma%20longifolia%20jack.pdf application/pdf en http://irep.iium.edu.my/56299/7/56299_The%20cholesterol%20lowering%20effects%20of%20Eurycoma%20longifolia%20Jack_WOS.pdf Faisal, Ghasak Ghazi and Abllah, Zurainie and Najmuldeen, Ghazi Faisal and Al-Ani, Ali Sabri Radeef (2017) The cholesterol lowering effects of Eurycoma longifolia Jack (Tongkat Ali) root extract in male rats. Makara Journal of Health Research, 21 (1). pp. 25-29. ISSN 2356-3664 E-ISSN 2356-3656 http://journal.ui.ac.id/index.php/health/index |
| spellingShingle | RB Pathology Faisal, Ghasak Ghazi Abllah, Zurainie Najmuldeen, Ghazi Faisal Al-Ani, Ali Sabri Radeef The cholesterol lowering effects of Eurycoma longifolia Jack (Tongkat Ali) root extract in male rats |
| title | The cholesterol lowering effects of Eurycoma longifolia Jack (Tongkat Ali) root extract in male rats |
| title_full | The cholesterol lowering effects of Eurycoma longifolia Jack (Tongkat Ali) root extract in male rats |
| title_fullStr | The cholesterol lowering effects of Eurycoma longifolia Jack (Tongkat Ali) root extract in male rats |
| title_full_unstemmed | The cholesterol lowering effects of Eurycoma longifolia Jack (Tongkat Ali) root extract in male rats |
| title_short | The cholesterol lowering effects of Eurycoma longifolia Jack (Tongkat Ali) root extract in male rats |
| title_sort | cholesterol lowering effects of eurycoma longifolia jack (tongkat ali) root extract in male rats |
| topic | RB Pathology |
| url | http://irep.iium.edu.my/56299/ http://irep.iium.edu.my/56299/ http://irep.iium.edu.my/56299/1/Cholesterol%20lowering%20effects%20of%20Eurycoma%20longifolia%20jack.pdf http://irep.iium.edu.my/56299/7/56299_The%20cholesterol%20lowering%20effects%20of%20Eurycoma%20longifolia%20Jack_WOS.pdf |