Preliminary screening of cytotoxic properties of Baccaurea angulata in several human cancer cell lines in vitro
Fruits have been acknowledged as a reservoir for numerous bioactive compounds. Baccaurea angulata, belonging to the Euphorbiaceae family, has been reported to contain several nutritional properties such as proteins and carbohydrates. Presently, B. angulata has not been fully exploited as little i...
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/55650/ http://irep.iium.edu.my/55650/1/55650_abstract.pdf |
| _version_ | 1848784612228071424 |
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| author | Abdull Rasad, Mohammad Syaiful Bahari |
| author_facet | Abdull Rasad, Mohammad Syaiful Bahari |
| author_sort | Abdull Rasad, Mohammad Syaiful Bahari |
| building | IIUM Repository |
| collection | Online Access |
| description | Fruits have been acknowledged as a reservoir for numerous bioactive compounds.
Baccaurea angulata, belonging to the Euphorbiaceae family, has been reported to contain
several nutritional properties such as proteins and carbohydrates. Presently, B. angulata
has not been fully exploited as little is known regarding its scientific properties. This
preliminary study aims to explore the cytotoxicity effects of various extracts and fibers of B.
angulata on human cancer cells. Cytotoxicity effects of B. angulata were evaluated on
cervix cancer (HeLa) and skin melanoma (A375) cells through treatment with hexane,
methanol and dichloromethane extracts of B. angulata as well as with novel B. angulata
fibers (whole fruit and berries) via direct contact method. The growth inhibitions of the
samples were evaluated through Methylene Blue Assay (MBA), with incubation time of 24,
48 and 72 hours. From the results, it was observed that for HeLa cells, berries showed the
highest growth inhibition (90.69 μg/mL, 72 hours). The solvent-based extracts were found
to be cytotoxic towards HeLa cells with methanol extracts exhibiting the highest
cytotoxicity with EC50 of 17.21 μg/mL. For A375 cells, all extracts also exhibited cytotoxic
effects, where the highest inhibition activity was induced by hexane extracts (89.40 μg/mL,
72 hours). Consequently, the study indicates that B. angulata fruit may have significant
growth inhibitory and cytotoxicity effects toward HeLa and A375 cells. It can be presumed
that B. angulata fruit has the potential to be used as a new alternative resource that could
be fundamental in future endeavors for prospective therapeutic treatments for cancer. |
| first_indexed | 2025-11-14T16:40:01Z |
| format | Proceeding Paper |
| id | iium-55650 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:40:01Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-556502022-06-14T02:35:01Z http://irep.iium.edu.my/55650/ Preliminary screening of cytotoxic properties of Baccaurea angulata in several human cancer cell lines in vitro Abdull Rasad, Mohammad Syaiful Bahari Q Science (General) Fruits have been acknowledged as a reservoir for numerous bioactive compounds. Baccaurea angulata, belonging to the Euphorbiaceae family, has been reported to contain several nutritional properties such as proteins and carbohydrates. Presently, B. angulata has not been fully exploited as little is known regarding its scientific properties. This preliminary study aims to explore the cytotoxicity effects of various extracts and fibers of B. angulata on human cancer cells. Cytotoxicity effects of B. angulata were evaluated on cervix cancer (HeLa) and skin melanoma (A375) cells through treatment with hexane, methanol and dichloromethane extracts of B. angulata as well as with novel B. angulata fibers (whole fruit and berries) via direct contact method. The growth inhibitions of the samples were evaluated through Methylene Blue Assay (MBA), with incubation time of 24, 48 and 72 hours. From the results, it was observed that for HeLa cells, berries showed the highest growth inhibition (90.69 μg/mL, 72 hours). The solvent-based extracts were found to be cytotoxic towards HeLa cells with methanol extracts exhibiting the highest cytotoxicity with EC50 of 17.21 μg/mL. For A375 cells, all extracts also exhibited cytotoxic effects, where the highest inhibition activity was induced by hexane extracts (89.40 μg/mL, 72 hours). Consequently, the study indicates that B. angulata fruit may have significant growth inhibitory and cytotoxicity effects toward HeLa and A375 cells. It can be presumed that B. angulata fruit has the potential to be used as a new alternative resource that could be fundamental in future endeavors for prospective therapeutic treatments for cancer. 2013 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/55650/1/55650_abstract.pdf Abdull Rasad, Mohammad Syaiful Bahari (2013) Preliminary screening of cytotoxic properties of Baccaurea angulata in several human cancer cell lines in vitro. In: International Conference on Medical and Health Sciences, 22th-24th May 2013, Kota Bharu, Kelantan. |
| spellingShingle | Q Science (General) Abdull Rasad, Mohammad Syaiful Bahari Preliminary screening of cytotoxic properties of Baccaurea angulata in several human cancer cell lines in vitro |
| title | Preliminary screening of cytotoxic properties of Baccaurea angulata in several human cancer cell lines in vitro |
| title_full | Preliminary screening of cytotoxic properties of Baccaurea angulata in several human cancer cell lines in vitro |
| title_fullStr | Preliminary screening of cytotoxic properties of Baccaurea angulata in several human cancer cell lines in vitro |
| title_full_unstemmed | Preliminary screening of cytotoxic properties of Baccaurea angulata in several human cancer cell lines in vitro |
| title_short | Preliminary screening of cytotoxic properties of Baccaurea angulata in several human cancer cell lines in vitro |
| title_sort | preliminary screening of cytotoxic properties of baccaurea angulata in several human cancer cell lines in vitro |
| topic | Q Science (General) |
| url | http://irep.iium.edu.my/55650/ http://irep.iium.edu.my/55650/1/55650_abstract.pdf |