Model of a critical size defect in the New Zealand White rabbit’s tibia
Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbit (Oryctolagus cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new bone substitute materials. There are varieties of protocols available in the literature...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Kulliyyah of Medicine, IIUM, Kuantan
2016
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| Online Access: | http://irep.iium.edu.my/55462/ http://irep.iium.edu.my/55462/1/Model%20of%20a%20critical%20size%20defect%20in%20the%20New%20Zealand%20White%20rabbit%E2%80%99s%20tibia.pdf |
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| author | Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Mohamed Amin, Mohamed Azril Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah |
| author_facet | Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Mohamed Amin, Mohamed Azril Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah |
| author_sort | Che Seman, Che Nor Zarida |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction:
Critical size defects (CSD) in the long bones of New Zealand White rabbit (Oryctolagus cuniculus) have been used for years as an experimental model for
investigation of the effectiveness of a new bone substitute materials. There are varieties of protocols available in the literature. This technical note attempts to present an
alternative surgical technique of a CSD in the New Zealand white rabbit tibia.
Methods:
Thirty-nine New Zealand White rabbits were used in this study. A CSD of approximately 4.5 mm (width) X 9.0 mm (length) was surgically drilled at the proximal tibial metaphysis, approximately 1 cm from the knee joint. The surrounding of soft tissue was repositioned and sutured layer by layer with bio absorbable surgical suture. Povidone soaked gauze and bandage were used as a dressing. There is no control group used in this study.
Results:
This alternative method created good CSD with less bleeding from the muscle observed.No mortality on other surgical complications were observed within 6 weeks, 12 weeks and
24 weeks following surgery. Conclusions: A simple and safe method for performing critical size defect was demonstrated and recommended as an approach for surgery on New
Zealand White rabbits. |
| first_indexed | 2025-11-14T16:39:33Z |
| format | Article |
| id | iium-55462 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:39:33Z |
| publishDate | 2016 |
| publisher | Kulliyyah of Medicine, IIUM, Kuantan |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-554622017-10-19T02:20:28Z http://irep.iium.edu.my/55462/ Model of a critical size defect in the New Zealand White rabbit’s tibia Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Mohamed Amin, Mohamed Azril Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah RD701 Orthopedics Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbit (Oryctolagus cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new bone substitute materials. There are varieties of protocols available in the literature. This technical note attempts to present an alternative surgical technique of a CSD in the New Zealand white rabbit tibia. Methods: Thirty-nine New Zealand White rabbits were used in this study. A CSD of approximately 4.5 mm (width) X 9.0 mm (length) was surgically drilled at the proximal tibial metaphysis, approximately 1 cm from the knee joint. The surrounding of soft tissue was repositioned and sutured layer by layer with bio absorbable surgical suture. Povidone soaked gauze and bandage were used as a dressing. There is no control group used in this study. Results: This alternative method created good CSD with less bleeding from the muscle observed.No mortality on other surgical complications were observed within 6 weeks, 12 weeks and 24 weeks following surgery. Conclusions: A simple and safe method for performing critical size defect was demonstrated and recommended as an approach for surgery on New Zealand White rabbits. Kulliyyah of Medicine, IIUM, Kuantan 2016-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/55462/1/Model%20of%20a%20critical%20size%20defect%20in%20the%20New%20Zealand%20White%20rabbit%E2%80%99s%20tibia.pdf Che Seman, Che Nor Zarida and Zakaria@Mohamad, Zamzuri and Mohamed Amin, Mohamed Azril and Awang, Mohd Shukrimi and Mohd Yusof, Nazri and Buyong, Zunariah (2016) Model of a critical size defect in the New Zealand White rabbit’s tibia. The International Medical Journal Malaysia ( IMJM ), 15 (Supplement Issue). p. 43. http://iiumedic.net/imjm/v1/vol-15-supplement-issue/ |
| spellingShingle | RD701 Orthopedics Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Mohamed Amin, Mohamed Azril Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah Model of a critical size defect in the New Zealand White rabbit’s tibia |
| title | Model of a critical size defect in the New Zealand White rabbit’s tibia |
| title_full | Model of a critical size defect in the New Zealand White rabbit’s tibia |
| title_fullStr | Model of a critical size defect in the New Zealand White rabbit’s tibia |
| title_full_unstemmed | Model of a critical size defect in the New Zealand White rabbit’s tibia |
| title_short | Model of a critical size defect in the New Zealand White rabbit’s tibia |
| title_sort | model of a critical size defect in the new zealand white rabbit’s tibia |
| topic | RD701 Orthopedics |
| url | http://irep.iium.edu.my/55462/ http://irep.iium.edu.my/55462/ http://irep.iium.edu.my/55462/1/Model%20of%20a%20critical%20size%20defect%20in%20the%20New%20Zealand%20White%20rabbit%E2%80%99s%20tibia.pdf |