Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells
The pre-inflammatory stage of atherosclerosis is associated with proteoglycan glycosaminoglycan (GAG) chain hyperelongation that results in increased proteoglycan binding to low density lipoprotein (LDL). Transforming Growth Factor-β (TGF-β) is closely associated with atherosclerosis and mediates GA...
| Main Authors: | , , , |
|---|---|
| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
2013
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/55300/ http://irep.iium.edu.my/55300/1/Print_Ashraf_AVBS%20Poster%20030913.pdf http://irep.iium.edu.my/55300/7/FINAL%20Program%20for%20AVBS_ANZMS%202013.pdf |
| _version_ | 1848784556199510016 |
|---|---|
| author | Rostam, Muhamad Ashraf Piva, Terence J. Osman, Narin Little, Peter J. |
| author_facet | Rostam, Muhamad Ashraf Piva, Terence J. Osman, Narin Little, Peter J. |
| author_sort | Rostam, Muhamad Ashraf |
| building | IIUM Repository |
| collection | Online Access |
| description | The pre-inflammatory stage of atherosclerosis is associated with proteoglycan glycosaminoglycan (GAG) chain hyperelongation that results in increased proteoglycan binding to low density lipoprotein (LDL). Transforming Growth Factor-β (TGF-β) is closely associated with atherosclerosis and mediates GAG chain hyperelongation.TGF-β signals through phosphorylation of Smad 2/3 at its C-terminus and it can also activate other kinases to phosphorylate Smad in the linker region. In vascular smooth muscle cells (VSMC) GAG chain hyperelongation is dependent upon transcription and translation but the targets of TGF-β signalling, most likely genes for GAG enzymes, remain unknown. A recent study by Anggraeni et al showed that GAG enzymes C4ST-1 and ChGn-2 involved in chondroitin sulphate (CS) GAG elongation have higher levels of expression in a mouse model of atherosclerosis. |
| first_indexed | 2025-11-14T16:39:07Z |
| format | Proceeding Paper |
| id | iium-55300 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:39:07Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-553002017-04-25T04:12:25Z http://irep.iium.edu.my/55300/ Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells Rostam, Muhamad Ashraf Piva, Terence J. Osman, Narin Little, Peter J. R Medicine (General) RM Therapeutics. Pharmacology The pre-inflammatory stage of atherosclerosis is associated with proteoglycan glycosaminoglycan (GAG) chain hyperelongation that results in increased proteoglycan binding to low density lipoprotein (LDL). Transforming Growth Factor-β (TGF-β) is closely associated with atherosclerosis and mediates GAG chain hyperelongation.TGF-β signals through phosphorylation of Smad 2/3 at its C-terminus and it can also activate other kinases to phosphorylate Smad in the linker region. In vascular smooth muscle cells (VSMC) GAG chain hyperelongation is dependent upon transcription and translation but the targets of TGF-β signalling, most likely genes for GAG enzymes, remain unknown. A recent study by Anggraeni et al showed that GAG enzymes C4ST-1 and ChGn-2 involved in chondroitin sulphate (CS) GAG elongation have higher levels of expression in a mouse model of atherosclerosis. 2013-09-05 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/55300/1/Print_Ashraf_AVBS%20Poster%20030913.pdf application/pdf en http://irep.iium.edu.my/55300/7/FINAL%20Program%20for%20AVBS_ANZMS%202013.pdf Rostam, Muhamad Ashraf and Piva, Terence J. and Osman, Narin and Little, Peter J. (2013) Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells. In: The 2013 Joint Meeting of AVBS & ANZMS, 5th-8th Sept. 2013, Novotel Resort, Barossa Valley, South Australia, Australia. (Unpublished) |
| spellingShingle | R Medicine (General) RM Therapeutics. Pharmacology Rostam, Muhamad Ashraf Piva, Terence J. Osman, Narin Little, Peter J. Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells |
| title | Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells |
| title_full | Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells |
| title_fullStr | Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells |
| title_full_unstemmed | Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells |
| title_short | Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells |
| title_sort | tgf-β stimulated glycosaminoglycan (gag) biosynthetic gene expression in vascular smooth muscle cells |
| topic | R Medicine (General) RM Therapeutics. Pharmacology |
| url | http://irep.iium.edu.my/55300/ http://irep.iium.edu.my/55300/1/Print_Ashraf_AVBS%20Poster%20030913.pdf http://irep.iium.edu.my/55300/7/FINAL%20Program%20for%20AVBS_ANZMS%202013.pdf |