Implementation of a prototype glomerular filtration rate application to monitor creatinine kinetic dynamics in critically ill patients
It has always been desirable for clinicians to ascertain whether glomerular filtration rate has recovered or still depressed at the bedside as increase in serum creatinine often indicates acute kidney injury to a clinician. In recent years, several clinical studies have developed mathematical models...
| Main Authors: | , , , |
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| Format: | Proceeding Paper |
| Language: | English English |
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IEEE
2016
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| Online Access: | http://irep.iium.edu.my/54920/ http://irep.iium.edu.my/54920/13/54920.pdf http://irep.iium.edu.my/54920/19/54920-Implementation%20of%20a%20prototype%20glomerular%20filtration%20rate%20application%20to%20monitor%20creatinine%20kinetic%20dynamics%20in%20critically%20ill%20patients_SCOPUS.pdf |
| _version_ | 1848784490389831680 |
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| author | Dzaharudin, Fatimah Md Ralib, Azrina Mat Nor, Mohd Basri Jamaludin, Ummu Kulthum |
| author_facet | Dzaharudin, Fatimah Md Ralib, Azrina Mat Nor, Mohd Basri Jamaludin, Ummu Kulthum |
| author_sort | Dzaharudin, Fatimah |
| building | IIUM Repository |
| collection | Online Access |
| description | It has always been desirable for clinicians to ascertain whether glomerular filtration rate has recovered or still depressed at the bedside as increase in serum creatinine often indicates acute kidney injury to a clinician. In recent years, several clinical studies have developed mathematical models to simulate the creatinine response to changes in glomerular filtration rate which includes the estimated glomerular filtration rate Chronic Kidney Disease Epidemiology Collaboration, the Chen-kinetic estimated GFR model and the modified Chen-Pianta-Endre-Pickering-Bukley-Pecke kinetic estimated GFR model. Another study also showed that the ratio of creatinine excretion rates to creatinine production rates may predict changes in plasma concentration. The aim of this study is to allow clinicians to gauge the performance of glomerular filtration rate estimation using the aforementioned equations and models to predict worsening of renal function, indicated by a low kinetic estimated glomerular filtration rate or creatinine production rates less than unity, or recovery of kidney function, indicated by high kinetic estimated glomerular filtration rate. In order to achieve this a mobile software is developed to aid data collection and calculation for the clinical study based on the aforementioned models. This paper summarises the implementation details of the native application development and presents the graphical user interface of the system in practice. |
| first_indexed | 2025-11-14T16:38:05Z |
| format | Proceeding Paper |
| id | iium-54920 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:38:05Z |
| publishDate | 2016 |
| publisher | IEEE |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-549202020-07-15T02:53:37Z http://irep.iium.edu.my/54920/ Implementation of a prototype glomerular filtration rate application to monitor creatinine kinetic dynamics in critically ill patients Dzaharudin, Fatimah Md Ralib, Azrina Mat Nor, Mohd Basri Jamaludin, Ummu Kulthum R Medicine (General) It has always been desirable for clinicians to ascertain whether glomerular filtration rate has recovered or still depressed at the bedside as increase in serum creatinine often indicates acute kidney injury to a clinician. In recent years, several clinical studies have developed mathematical models to simulate the creatinine response to changes in glomerular filtration rate which includes the estimated glomerular filtration rate Chronic Kidney Disease Epidemiology Collaboration, the Chen-kinetic estimated GFR model and the modified Chen-Pianta-Endre-Pickering-Bukley-Pecke kinetic estimated GFR model. Another study also showed that the ratio of creatinine excretion rates to creatinine production rates may predict changes in plasma concentration. The aim of this study is to allow clinicians to gauge the performance of glomerular filtration rate estimation using the aforementioned equations and models to predict worsening of renal function, indicated by a low kinetic estimated glomerular filtration rate or creatinine production rates less than unity, or recovery of kidney function, indicated by high kinetic estimated glomerular filtration rate. In order to achieve this a mobile software is developed to aid data collection and calculation for the clinical study based on the aforementioned models. This paper summarises the implementation details of the native application development and presents the graphical user interface of the system in practice. IEEE 2016 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/54920/13/54920.pdf application/pdf en http://irep.iium.edu.my/54920/19/54920-Implementation%20of%20a%20prototype%20glomerular%20filtration%20rate%20application%20to%20monitor%20creatinine%20kinetic%20dynamics%20in%20critically%20ill%20patients_SCOPUS.pdf Dzaharudin, Fatimah and Md Ralib, Azrina and Mat Nor, Mohd Basri and Jamaludin, Ummu Kulthum (2016) Implementation of a prototype glomerular filtration rate application to monitor creatinine kinetic dynamics in critically ill patients. In: 2016 IEEE EMBS Conference on Biomedical Engineering and Sciences (IECBES), 4th-8th December 2016, Kuala Lumpur. http://ieeexplore.ieee.org/document/7843412/ 10.1109/IECBES.2016.7843412 |
| spellingShingle | R Medicine (General) Dzaharudin, Fatimah Md Ralib, Azrina Mat Nor, Mohd Basri Jamaludin, Ummu Kulthum Implementation of a prototype glomerular filtration rate application to monitor creatinine kinetic dynamics in critically ill patients |
| title | Implementation of a prototype glomerular filtration rate application to monitor creatinine kinetic dynamics in critically ill patients |
| title_full | Implementation of a prototype glomerular filtration rate application to monitor creatinine kinetic dynamics in critically ill patients |
| title_fullStr | Implementation of a prototype glomerular filtration rate application to monitor creatinine kinetic dynamics in critically ill patients |
| title_full_unstemmed | Implementation of a prototype glomerular filtration rate application to monitor creatinine kinetic dynamics in critically ill patients |
| title_short | Implementation of a prototype glomerular filtration rate application to monitor creatinine kinetic dynamics in critically ill patients |
| title_sort | implementation of a prototype glomerular filtration rate application to monitor creatinine kinetic dynamics in critically ill patients |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/54920/ http://irep.iium.edu.my/54920/ http://irep.iium.edu.my/54920/ http://irep.iium.edu.my/54920/13/54920.pdf http://irep.iium.edu.my/54920/19/54920-Implementation%20of%20a%20prototype%20glomerular%20filtration%20rate%20application%20to%20monitor%20creatinine%20kinetic%20dynamics%20in%20critically%20ill%20patients_SCOPUS.pdf |