Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes)
Postmenopausal osteoporosis is one of the main health problems in aging women. It was due to several factors including oxidative stress, which can be controlled through intake of antioxidants from food sources. Virgin coconut oil (VCO) is one of the natural product rich in an...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universiti Kebangsaan Malaysia
2016
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/54872/ http://irep.iium.edu.my/54872/1/05%20Shidqiyyah.pdf |
| _version_ | 1848784481873297408 |
|---|---|
| author | Abdul-Hamid, Shidqiyyah Muhammad, Norliza Naina Mohamed, Isa |
| author_facet | Abdul-Hamid, Shidqiyyah Muhammad, Norliza Naina Mohamed, Isa |
| author_sort | Abdul-Hamid, Shidqiyyah |
| building | IIUM Repository |
| collection | Online Access |
| description | Postmenopausal osteoporosis is one of the main health problems in aging women. It was due to several factors including oxidative stress, which can be controlled through intake of antioxidants from food sources. Virgin coconut oil (VCO) is one of the natural product rich in antioxidants and has been proven to protect osteoporotic bone. This study was
conducted to gain in-depth understanding on virgin coconut oil’s activity on osteoporosis at molecular level. Thirty two female Sprague-Dawley rats were divided into four groups, namely Sham operated group, ovariectomized control group (Ovx+Ctrl), ovariectomized with VCO
treatment (Ovx+ VCO), and ovariectomized with estrogen treatment (Ovx+E). All treatments were administered orally for ten weeks. Bone samples were obtained to examine changes on expression of superoxide dismutase (SOD),glutathione peroxidase (GPX), osteocalcin and runt-related transcription factor 2 (Runx2)
genes. The results indicated that rats receiving VCO
treatment had experienced significant increments in SOD,
GPX and osteocalcin gene expressions compared to the ovariectomized control group, besides the gene expressions of Runx2 which also showed an increment pattern. In conclusion, VCO helps to protect bone in osteoporotic rat model by increasing the expressions of antioxidant genes and genes which increase the osteoblast acitivities. |
| first_indexed | 2025-11-14T16:37:56Z |
| format | Article |
| id | iium-54872 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:37:56Z |
| publishDate | 2016 |
| publisher | Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-548722017-07-18T06:05:58Z http://irep.iium.edu.my/54872/ Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes) Abdul-Hamid, Shidqiyyah Muhammad, Norliza Naina Mohamed, Isa R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica Postmenopausal osteoporosis is one of the main health problems in aging women. It was due to several factors including oxidative stress, which can be controlled through intake of antioxidants from food sources. Virgin coconut oil (VCO) is one of the natural product rich in antioxidants and has been proven to protect osteoporotic bone. This study was conducted to gain in-depth understanding on virgin coconut oil’s activity on osteoporosis at molecular level. Thirty two female Sprague-Dawley rats were divided into four groups, namely Sham operated group, ovariectomized control group (Ovx+Ctrl), ovariectomized with VCO treatment (Ovx+ VCO), and ovariectomized with estrogen treatment (Ovx+E). All treatments were administered orally for ten weeks. Bone samples were obtained to examine changes on expression of superoxide dismutase (SOD),glutathione peroxidase (GPX), osteocalcin and runt-related transcription factor 2 (Runx2) genes. The results indicated that rats receiving VCO treatment had experienced significant increments in SOD, GPX and osteocalcin gene expressions compared to the ovariectomized control group, besides the gene expressions of Runx2 which also showed an increment pattern. In conclusion, VCO helps to protect bone in osteoporotic rat model by increasing the expressions of antioxidant genes and genes which increase the osteoblast acitivities. Universiti Kebangsaan Malaysia 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/54872/1/05%20Shidqiyyah.pdf Abdul-Hamid, Shidqiyyah and Muhammad, Norliza and Naina Mohamed, Isa (2016) Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes). Sains Malaysiana, 45 (12). pp. 1815-1822. ISSN 0126-6039 http://www.ukm.my/jsm/pdf_files/SM-PDF-45-12-2016/05%20Shidqiyyah.pdf |
| spellingShingle | R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica Abdul-Hamid, Shidqiyyah Muhammad, Norliza Naina Mohamed, Isa Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes) |
| title | Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes) |
| title_full | Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes) |
| title_fullStr | Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes) |
| title_full_unstemmed | Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes) |
| title_short | Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes) |
| title_sort | tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes) |
| topic | R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/54872/ http://irep.iium.edu.my/54872/ http://irep.iium.edu.my/54872/1/05%20Shidqiyyah.pdf |