Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound
Despite most anticancer drugs possess potent cell killing activity in vitro studies; the selective delivery of drugs to cancer cells is thus far becomes a major challenge to oncology. The non-specific actions of drugs on healthy cells cause many restrictions in clinical use due to their systemic tox...
| Main Authors: | , , |
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
Kulliyyah of Allied Health Sciences, IIUM
2016
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| Online Access: | http://irep.iium.edu.my/54665/ http://irep.iium.edu.my/54665/7/54665%20Comparison%20between%20Cold%20Temperature.pdf |
| _version_ | 1848784449611759616 |
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| author | Sahabudin, Adzly H Abdul Ghani, Radiah Fong, Fiona How Ni |
| author_facet | Sahabudin, Adzly H Abdul Ghani, Radiah Fong, Fiona How Ni |
| author_sort | Sahabudin, Adzly H |
| building | IIUM Repository |
| collection | Online Access |
| description | Despite most anticancer drugs possess potent cell killing activity in vitro studies; the selective delivery of drugs to cancer cells is thus far becomes a major challenge to oncology. The non-specific actions of drugs on healthy cells cause many restrictions in clinical use due to their systemic toxicity. In respond to this matter, specific targeting of anticancer drugs towards cancer cells can be achieved by attaching them to a molecule that is transported into cancer cells via a selective transport system. Carbon disulphides were attached to a polyamine to reduce the effects of cancer cells as sulphurs were known for its anti-cancer properties. For the synthesis, two methods were used. The first method involved the synthesis done in a cold environment while the other in a room temperature environment. The temperature differences had shown to influence the yield as well as the chemical structure of the drug. The effect could also be seen on the amount of solvent used during the process. For the room temperature mediated synthesis, the formation of solid compounds produce was higher and faster as compared to the cold mediated synthesis. Repetition of both methods showed that it was dependable as it produced the same compounds based on the Fourier transformed infrared spectroscopy results. In comparison, the room temp mediated synthesis was more efficient as it produced better yield. |
| first_indexed | 2025-11-14T16:37:26Z |
| format | Proceeding Paper |
| id | iium-54665 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:37:26Z |
| publishDate | 2016 |
| publisher | Kulliyyah of Allied Health Sciences, IIUM |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-546652018-06-29T03:19:11Z http://irep.iium.edu.my/54665/ Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound Sahabudin, Adzly H Abdul Ghani, Radiah Fong, Fiona How Ni QD Chemistry Despite most anticancer drugs possess potent cell killing activity in vitro studies; the selective delivery of drugs to cancer cells is thus far becomes a major challenge to oncology. The non-specific actions of drugs on healthy cells cause many restrictions in clinical use due to their systemic toxicity. In respond to this matter, specific targeting of anticancer drugs towards cancer cells can be achieved by attaching them to a molecule that is transported into cancer cells via a selective transport system. Carbon disulphides were attached to a polyamine to reduce the effects of cancer cells as sulphurs were known for its anti-cancer properties. For the synthesis, two methods were used. The first method involved the synthesis done in a cold environment while the other in a room temperature environment. The temperature differences had shown to influence the yield as well as the chemical structure of the drug. The effect could also be seen on the amount of solvent used during the process. For the room temperature mediated synthesis, the formation of solid compounds produce was higher and faster as compared to the cold mediated synthesis. Repetition of both methods showed that it was dependable as it produced the same compounds based on the Fourier transformed infrared spectroscopy results. In comparison, the room temp mediated synthesis was more efficient as it produced better yield. Kulliyyah of Allied Health Sciences, IIUM 2016 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/54665/7/54665%20Comparison%20between%20Cold%20Temperature.pdf Sahabudin, Adzly H and Abdul Ghani, Radiah and Fong, Fiona How Ni (2016) Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound. In: KAHS Research Week (KRW) 2016 in conjunction with 1st Allied Health Scientific Colloquium (AHSC) 2016, 21 - 25 November 2016, Pahang, Malaysia. |
| spellingShingle | QD Chemistry Sahabudin, Adzly H Abdul Ghani, Radiah Fong, Fiona How Ni Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound |
| title | Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound |
| title_full | Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound |
| title_fullStr | Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound |
| title_full_unstemmed | Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound |
| title_short | Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound |
| title_sort | comparison between cold temperature (≤ 4°c) and room temperature (≈25°c) mediated synthesis for putrescine-sulphur compound |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/54665/ http://irep.iium.edu.my/54665/7/54665%20Comparison%20between%20Cold%20Temperature.pdf |