Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract
Antilipase from natural resources are a potential tool for the treatment of obesity while antioxidant-rich plants are essential in combating degenerative diseases. The aim of this study is to determine the antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract. The inhibitor...
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| Format: | Proceeding Paper |
| Language: | English |
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Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
2016
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| Online Access: | http://irep.iium.edu.my/54631/ http://irep.iium.edu.my/54631/1/MRS%20for%20IREP.pdf |
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| author | Alias, Norsyuhada Leow, Adam Thean Chor Mohamad Ali, Mohd. Shukuri Salleh, Abu Bakar Ahmad Tajudin, Asilah Raja Abd. Rahman, Raja Noor Zaliha |
| author_facet | Alias, Norsyuhada Leow, Adam Thean Chor Mohamad Ali, Mohd. Shukuri Salleh, Abu Bakar Ahmad Tajudin, Asilah Raja Abd. Rahman, Raja Noor Zaliha |
| author_sort | Alias, Norsyuhada |
| building | IIUM Repository |
| collection | Online Access |
| description | Antilipase from natural resources are a potential tool for the treatment of obesity while antioxidant-rich plants are essential in combating degenerative diseases. The aim of this study is to determine the antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract. The inhibitory activity against pancreatic lipase was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol at 405 nm. Antioxidant activity of O. stamineus extract was measured by 2, 2, diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity assay. The O. stamineus crude extract exhibited strong lipase inhibitory activity with an IC50 value of 34.7 µg/ml. The inhibition mode study disclosed that O. stamineus could act as uncompetitive inhibitor. O. stamineus showed high antioxidant activity with an EC50 value of 26.3 µg/ml. The results suggest that O. stamineus has shown potential as a source of natural antilipase and antioxidant. |
| first_indexed | 2025-11-14T16:37:20Z |
| format | Proceeding Paper |
| id | iium-54631 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:37:20Z |
| publishDate | 2016 |
| publisher | Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-546312017-02-01T09:48:28Z http://irep.iium.edu.my/54631/ Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract Alias, Norsyuhada Leow, Adam Thean Chor Mohamad Ali, Mohd. Shukuri Salleh, Abu Bakar Ahmad Tajudin, Asilah Raja Abd. Rahman, Raja Noor Zaliha RM Therapeutics. Pharmacology Antilipase from natural resources are a potential tool for the treatment of obesity while antioxidant-rich plants are essential in combating degenerative diseases. The aim of this study is to determine the antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract. The inhibitory activity against pancreatic lipase was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol at 405 nm. Antioxidant activity of O. stamineus extract was measured by 2, 2, diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity assay. The O. stamineus crude extract exhibited strong lipase inhibitory activity with an IC50 value of 34.7 µg/ml. The inhibition mode study disclosed that O. stamineus could act as uncompetitive inhibitor. O. stamineus showed high antioxidant activity with an EC50 value of 26.3 µg/ml. The results suggest that O. stamineus has shown potential as a source of natural antilipase and antioxidant. Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2016-12 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/54631/1/MRS%20for%20IREP.pdf Alias, Norsyuhada and Leow, Adam Thean Chor and Mohamad Ali, Mohd. Shukuri and Salleh, Abu Bakar and Ahmad Tajudin, Asilah and Raja Abd. Rahman, Raja Noor Zaliha (2016) Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract. In: Medical Research Symposium & Pacific Partnership in conjunction with Kuantan Research Day 2016, 3rd-6th August 2016, Kuantan, Pahang. http://iiumedic.net/imjm/v1/download/Volume%2015%20Supplement/MRS2016-ABSTRACT-BOOK-50.pdf |
| spellingShingle | RM Therapeutics. Pharmacology Alias, Norsyuhada Leow, Adam Thean Chor Mohamad Ali, Mohd. Shukuri Salleh, Abu Bakar Ahmad Tajudin, Asilah Raja Abd. Rahman, Raja Noor Zaliha Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract |
| title | Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract |
| title_full | Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract |
| title_fullStr | Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract |
| title_full_unstemmed | Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract |
| title_short | Antilipase and antioxidant activity of Orthosiphon stamineus methanolic extract |
| title_sort | antilipase and antioxidant activity of orthosiphon stamineus methanolic extract |
| topic | RM Therapeutics. Pharmacology |
| url | http://irep.iium.edu.my/54631/ http://irep.iium.edu.my/54631/ http://irep.iium.edu.my/54631/1/MRS%20for%20IREP.pdf |