Metabolomics as a tool in identification of bioactive compounds
Nature is a huge library for bioactive compounds. The challenge of natural chemists is to identify as much as possible the bioactive compounds and to study their mode of action to treat the diseases. This work is not easy due to the complexity of the compounds and limitation of time and budget. Lead...
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| Format: | Proceeding Paper |
| Language: | English |
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2016
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| Online Access: | http://irep.iium.edu.my/53580/ http://irep.iium.edu.my/53580/6/53580-edited.pdf |
| _version_ | 1848784253828988928 |
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| author | Khatib, Alfi |
| author_facet | Khatib, Alfi |
| author_sort | Khatib, Alfi |
| building | IIUM Repository |
| collection | Online Access |
| description | Nature is a huge library for bioactive compounds. The challenge of natural chemists is to identify as much as possible the bioactive compounds and to study their mode of action to treat the diseases. This work is not easy due to the complexity of the compounds and limitation of time and budget. Lead finding with bioassay guided fractionation developing into high throughput screening could not increase the number of potential natural products in the pipeline of the pharmaceutical companies. Therefore, a new approach amends the inclusion of system biology in pharmacognosy research by using metabolomics as a tool. Metabolomics is a comprehensive analysis of the whole metabolites in a sample. Identification of both chemical and bio-markers can be performed by the instrumental analysis of both natural sources and animal biofluids and multivariate data analysis. All advanced instrumentation such as nuclear magnetic resonance spectroscopy, liquid chromatography-mass spectrometry, and gas chromatography-mass spectrometry are used in metabolomics. |
| first_indexed | 2025-11-14T16:34:19Z |
| format | Proceeding Paper |
| id | iium-53580 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:34:19Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-535802016-12-28T01:58:02Z http://irep.iium.edu.my/53580/ Metabolomics as a tool in identification of bioactive compounds Khatib, Alfi Q Science (General) Nature is a huge library for bioactive compounds. The challenge of natural chemists is to identify as much as possible the bioactive compounds and to study their mode of action to treat the diseases. This work is not easy due to the complexity of the compounds and limitation of time and budget. Lead finding with bioassay guided fractionation developing into high throughput screening could not increase the number of potential natural products in the pipeline of the pharmaceutical companies. Therefore, a new approach amends the inclusion of system biology in pharmacognosy research by using metabolomics as a tool. Metabolomics is a comprehensive analysis of the whole metabolites in a sample. Identification of both chemical and bio-markers can be performed by the instrumental analysis of both natural sources and animal biofluids and multivariate data analysis. All advanced instrumentation such as nuclear magnetic resonance spectroscopy, liquid chromatography-mass spectrometry, and gas chromatography-mass spectrometry are used in metabolomics. 2016-09 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/53580/6/53580-edited.pdf Khatib, Alfi (2016) Metabolomics as a tool in identification of bioactive compounds. In: 1st Annual Pharmacy Conference : Eksplorasi Keanekaragaman Hayati Indonesia Untuk Pengembangan Jamu Berbasis Saintifik, 3rd-4th September 2016, Surakarta, Indonesia. (Unpublished) |
| spellingShingle | Q Science (General) Khatib, Alfi Metabolomics as a tool in identification of bioactive compounds |
| title | Metabolomics as a tool in identification of bioactive compounds |
| title_full | Metabolomics as a tool in identification of bioactive compounds |
| title_fullStr | Metabolomics as a tool in identification of bioactive compounds |
| title_full_unstemmed | Metabolomics as a tool in identification of bioactive compounds |
| title_short | Metabolomics as a tool in identification of bioactive compounds |
| title_sort | metabolomics as a tool in identification of bioactive compounds |
| topic | Q Science (General) |
| url | http://irep.iium.edu.my/53580/ http://irep.iium.edu.my/53580/6/53580-edited.pdf |