Metabolite profiling of Clinacanthus nutans leaves extracts obtained from different drying methods by 1H NMR-based metabolomics
The metabolites of Clinacanthus nutans leaves extracts and their dependence on drying process were systematically characterized using 1H nuclear magnetic resonance spectroscopy (NMR) multivariate data analysis. Principal component analysis (PCA) and partial least square-discriminant analysis (PLS-DA...
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| Format: | Proceeding Paper |
| Language: | English English English |
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AIP Publishing
2016
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| Online Access: | http://irep.iium.edu.my/52299/ http://irep.iium.edu.my/52299/13/hashim2016.pdf http://irep.iium.edu.my/52299/1/52299_Metabolite%20profiling%20of%20Clinacanthus_MYRA.pdf http://irep.iium.edu.my/52299/2/52299_Metabolite%20profiling%20of%20Clinacanthus_SCOPUS.pdf |
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| author | Noor Hashim, Noor Haslinda Latip, Jalifah Khatib, Alfi |
| author_facet | Noor Hashim, Noor Haslinda Latip, Jalifah Khatib, Alfi |
| author_sort | Noor Hashim, Noor Haslinda |
| building | IIUM Repository |
| collection | Online Access |
| description | The metabolites of Clinacanthus nutans leaves extracts and their dependence on drying process were systematically characterized using 1H nuclear magnetic resonance spectroscopy (NMR) multivariate data analysis. Principal component analysis (PCA) and partial least square-discriminant analysis (PLS-DA) were able to distinguish the leaves extracts obtained from different drying methods. The identified metabolites were carbohydrates, amino acid, flavonoids and sulfur glucoside compounds. The major metabolites responsible for the separation in PLS-DA loading plots were lupeol, cycloclinacosides, betulin, cerebrosides and choline. The results showed that the combination of 1H NMR spectroscopy and multivariate data analyses could act as an efficient technique to understand the C. nutans composition and its variation. © 2016 Author(s). |
| first_indexed | 2025-11-14T16:30:47Z |
| format | Proceeding Paper |
| id | iium-52299 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T16:30:47Z |
| publishDate | 2016 |
| publisher | AIP Publishing |
| recordtype | eprints |
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| spelling | iium-522992019-10-14T01:59:53Z http://irep.iium.edu.my/52299/ Metabolite profiling of Clinacanthus nutans leaves extracts obtained from different drying methods by 1H NMR-based metabolomics Noor Hashim, Noor Haslinda Latip, Jalifah Khatib, Alfi RM Therapeutics. Pharmacology The metabolites of Clinacanthus nutans leaves extracts and their dependence on drying process were systematically characterized using 1H nuclear magnetic resonance spectroscopy (NMR) multivariate data analysis. Principal component analysis (PCA) and partial least square-discriminant analysis (PLS-DA) were able to distinguish the leaves extracts obtained from different drying methods. The identified metabolites were carbohydrates, amino acid, flavonoids and sulfur glucoside compounds. The major metabolites responsible for the separation in PLS-DA loading plots were lupeol, cycloclinacosides, betulin, cerebrosides and choline. The results showed that the combination of 1H NMR spectroscopy and multivariate data analyses could act as an efficient technique to understand the C. nutans composition and its variation. © 2016 Author(s). AIP Publishing 2016-11-17 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/52299/13/hashim2016.pdf application/pdf en http://irep.iium.edu.my/52299/1/52299_Metabolite%20profiling%20of%20Clinacanthus_MYRA.pdf application/pdf en http://irep.iium.edu.my/52299/2/52299_Metabolite%20profiling%20of%20Clinacanthus_SCOPUS.pdf Noor Hashim, Noor Haslinda and Latip, Jalifah and Khatib, Alfi (2016) Metabolite profiling of Clinacanthus nutans leaves extracts obtained from different drying methods by 1H NMR-based metabolomics. In: 2016 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2016, 13th-14th April 2016, Selangor. http://aip.scitation.org/doi/abs/10.1063/1.4966753 10.1063/1.4966753 |
| spellingShingle | RM Therapeutics. Pharmacology Noor Hashim, Noor Haslinda Latip, Jalifah Khatib, Alfi Metabolite profiling of Clinacanthus nutans leaves extracts obtained from different drying methods by 1H NMR-based metabolomics |
| title | Metabolite profiling of Clinacanthus nutans leaves extracts obtained from different drying methods by 1H NMR-based metabolomics |
| title_full | Metabolite profiling of Clinacanthus nutans leaves extracts obtained from different drying methods by 1H NMR-based metabolomics |
| title_fullStr | Metabolite profiling of Clinacanthus nutans leaves extracts obtained from different drying methods by 1H NMR-based metabolomics |
| title_full_unstemmed | Metabolite profiling of Clinacanthus nutans leaves extracts obtained from different drying methods by 1H NMR-based metabolomics |
| title_short | Metabolite profiling of Clinacanthus nutans leaves extracts obtained from different drying methods by 1H NMR-based metabolomics |
| title_sort | metabolite profiling of clinacanthus nutans leaves extracts obtained from different drying methods by 1h nmr-based metabolomics |
| topic | RM Therapeutics. Pharmacology |
| url | http://irep.iium.edu.my/52299/ http://irep.iium.edu.my/52299/ http://irep.iium.edu.my/52299/ http://irep.iium.edu.my/52299/13/hashim2016.pdf http://irep.iium.edu.my/52299/1/52299_Metabolite%20profiling%20of%20Clinacanthus_MYRA.pdf http://irep.iium.edu.my/52299/2/52299_Metabolite%20profiling%20of%20Clinacanthus_SCOPUS.pdf |