Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers
To examine the effect of cryopreservation on developmental potential of human embryos, this study compared quantitative β-HCG concentrations at pregnancy test after IVF-fresh embryo transfer (IVF-ET) with those arising after frozen embryo transfer (FET). It also tracked outcomes of singleton pregnan...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier Ltd
2016
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| Online Access: | http://irep.iium.edu.my/52266/ http://irep.iium.edu.my/52266/1/52266_Higher%20HCG.pdf http://irep.iium.edu.my/52266/2/52266_Higher%20%CE%B2-HCG_SCOPUS.pdf |
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| author | Keane, Kevin N Mustafa, Kamarul Bahyah Hinchliffe, Peter Conceicao, Jason Yovich, John L |
| author_facet | Keane, Kevin N Mustafa, Kamarul Bahyah Hinchliffe, Peter Conceicao, Jason Yovich, John L |
| author_sort | Keane, Kevin N |
| building | IIUM Repository |
| collection | Online Access |
| description | To examine the effect of cryopreservation on developmental potential of human embryos, this study compared quantitative β-HCG concentrations at pregnancy test after IVF-fresh embryo transfer (IVF-ET) with those arising after frozen embryo transfer (FET). It also tracked outcomes of singleton pregnancies resulting from single-embryo transfers that resulted in singleton live births (n = 869; with 417 derived from IVF-ET and 452 from FET). The initial serum β-HCG concentration indicating successful implantation was measured along with the birthweight of the ensuing infants. With testing at equivalent luteal phase lengths, the median pregnancy test β-HCG was significantly higher following FET compared with fresh IVF-ET (844.5 IU/l versus 369 IU/l; P < 0.001). Despite no significant difference in the average period of gestation (38 weeks 5 days for both groups), the mean birthweight of infants born following FET was significantly heavier by 161 g (3370 g versus 3209 g; P < 0.001). Furthermore, more infants exceeded 4000 g (P < 0.001) for FET although there was no significant difference for the macrosomic category (≥4500 g). We concluded that FET programme embryos lead to infants with equivalent (if not better) developmental potential compared with IVF-ET, demonstrated by higher pregnancy β-HCG concentrations and ensuing birthweights. |
| first_indexed | 2025-11-14T16:30:41Z |
| format | Article |
| id | iium-52266 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:30:41Z |
| publishDate | 2016 |
| publisher | Elsevier Ltd |
| recordtype | eprints |
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| spelling | iium-522662017-06-05T03:35:31Z http://irep.iium.edu.my/52266/ Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers Keane, Kevin N Mustafa, Kamarul Bahyah Hinchliffe, Peter Conceicao, Jason Yovich, John L RG Gynecology and obstetrics To examine the effect of cryopreservation on developmental potential of human embryos, this study compared quantitative β-HCG concentrations at pregnancy test after IVF-fresh embryo transfer (IVF-ET) with those arising after frozen embryo transfer (FET). It also tracked outcomes of singleton pregnancies resulting from single-embryo transfers that resulted in singleton live births (n = 869; with 417 derived from IVF-ET and 452 from FET). The initial serum β-HCG concentration indicating successful implantation was measured along with the birthweight of the ensuing infants. With testing at equivalent luteal phase lengths, the median pregnancy test β-HCG was significantly higher following FET compared with fresh IVF-ET (844.5 IU/l versus 369 IU/l; P < 0.001). Despite no significant difference in the average period of gestation (38 weeks 5 days for both groups), the mean birthweight of infants born following FET was significantly heavier by 161 g (3370 g versus 3209 g; P < 0.001). Furthermore, more infants exceeded 4000 g (P < 0.001) for FET although there was no significant difference for the macrosomic category (≥4500 g). We concluded that FET programme embryos lead to infants with equivalent (if not better) developmental potential compared with IVF-ET, demonstrated by higher pregnancy β-HCG concentrations and ensuing birthweights. Elsevier Ltd 2016-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/52266/1/52266_Higher%20HCG.pdf application/pdf en http://irep.iium.edu.my/52266/2/52266_Higher%20%CE%B2-HCG_SCOPUS.pdf Keane, Kevin N and Mustafa, Kamarul Bahyah and Hinchliffe, Peter and Conceicao, Jason and Yovich, John L (2016) Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers. Reproductive BioMedicine Online, 33 (2). pp. 149-160. ISSN 1472-6483 http://www.sciencedirect.com/science/article/pii/S1472648316302905 10.1016/j.rbmo.2016.04.014 |
| spellingShingle | RG Gynecology and obstetrics Keane, Kevin N Mustafa, Kamarul Bahyah Hinchliffe, Peter Conceicao, Jason Yovich, John L Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers |
| title | Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers |
| title_full | Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers |
| title_fullStr | Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers |
| title_full_unstemmed | Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers |
| title_short | Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers |
| title_sort | higher β-hcg concentrations and higher birthweights ensue from single vitrified embryo transfers |
| topic | RG Gynecology and obstetrics |
| url | http://irep.iium.edu.my/52266/ http://irep.iium.edu.my/52266/ http://irep.iium.edu.my/52266/ http://irep.iium.edu.my/52266/1/52266_Higher%20HCG.pdf http://irep.iium.edu.my/52266/2/52266_Higher%20%CE%B2-HCG_SCOPUS.pdf |