Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres
Biodegradable poly(lactide-co-glycolide) (PLGA) microspheres have received much attention over the last twenty-five years for controlled parenteral delivery of therapeutic protein and peptide drugs [1, 2]. In general, for protein drugs delivery, PLGA and PLGA-based single-polymer microspheres system...
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| Format: | Proceeding Paper |
| Language: | English English |
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2016
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| Online Access: | http://irep.iium.edu.my/52222/ http://irep.iium.edu.my/52222/2/participation%20Cert.%20scan.jpg http://irep.iium.edu.my/52222/13/52222.pdf |
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| author | Rahman, Md. Mokhlesur Ansary, R.H. Mohamed, Farahidah Kasmuri, Abdul Razak Md Aris, Mohd Aznan Katas, H Awang, M.B. |
| author_facet | Rahman, Md. Mokhlesur Ansary, R.H. Mohamed, Farahidah Kasmuri, Abdul Razak Md Aris, Mohd Aznan Katas, H Awang, M.B. |
| author_sort | Rahman, Md. Mokhlesur |
| building | IIUM Repository |
| collection | Online Access |
| description | Biodegradable poly(lactide-co-glycolide) (PLGA) microspheres have received much attention over the last twenty-five years for controlled parenteral delivery of therapeutic protein and peptide drugs [1, 2]. In general, for protein drugs delivery, PLGA and PLGA-based single-polymer microspheres system still suffer from two major technical problems associated with their inherent stability problem [3]. Initial burst release followed by very slow and incomplete release is one of the most serious problems in the formulation of PLGA-based protein drugs delivery system. Many strategies have been explored currently to reduce the high initial burst release of protein and peptide drugs from PLGA microspheres [4]. Fabrication of double-walled microspheres in which protein drugs encapsulated in the inner core surrounded by a drug free outer polymer layer offers a promising technique in reducing the high initial burst release. In previous studies, large size double-walled microspheres have been prepared using poly(L-lactic acid) (PLLA) and different co-polymers of PLGA (ester-terminated and carboxyl-terminated) as the core and shell material. Double-walled microspheres consisting PLLA and ester-terminated PLGA as the core or shell material required more time for the complete release of encapsulated drugs due to the slow degrading nature of these polymers. |
| first_indexed | 2025-11-14T16:30:34Z |
| format | Proceeding Paper |
| id | iium-52222 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:30:34Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-522222022-07-07T07:13:05Z http://irep.iium.edu.my/52222/ Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres Rahman, Md. Mokhlesur Ansary, R.H. Mohamed, Farahidah Kasmuri, Abdul Razak Md Aris, Mohd Aznan Katas, H Awang, M.B. QD Chemistry Biodegradable poly(lactide-co-glycolide) (PLGA) microspheres have received much attention over the last twenty-five years for controlled parenteral delivery of therapeutic protein and peptide drugs [1, 2]. In general, for protein drugs delivery, PLGA and PLGA-based single-polymer microspheres system still suffer from two major technical problems associated with their inherent stability problem [3]. Initial burst release followed by very slow and incomplete release is one of the most serious problems in the formulation of PLGA-based protein drugs delivery system. Many strategies have been explored currently to reduce the high initial burst release of protein and peptide drugs from PLGA microspheres [4]. Fabrication of double-walled microspheres in which protein drugs encapsulated in the inner core surrounded by a drug free outer polymer layer offers a promising technique in reducing the high initial burst release. In previous studies, large size double-walled microspheres have been prepared using poly(L-lactic acid) (PLLA) and different co-polymers of PLGA (ester-terminated and carboxyl-terminated) as the core and shell material. Double-walled microspheres consisting PLLA and ester-terminated PLGA as the core or shell material required more time for the complete release of encapsulated drugs due to the slow degrading nature of these polymers. 2016 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/52222/2/participation%20Cert.%20scan.jpg application/pdf en http://irep.iium.edu.my/52222/13/52222.pdf Rahman, Md. Mokhlesur and Ansary, R.H. and Mohamed, Farahidah and Kasmuri, Abdul Razak and Md Aris, Mohd Aznan and Katas, H and Awang, M.B. (2016) Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres. In: International Conference on Industrial Pharmacy (2nd ICIP 2016), 15th-16th Aug. 2016, Kuantan, Pahang. (Unpublished) |
| spellingShingle | QD Chemistry Rahman, Md. Mokhlesur Ansary, R.H. Mohamed, Farahidah Kasmuri, Abdul Razak Md Aris, Mohd Aznan Katas, H Awang, M.B. Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres |
| title | Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres |
| title_full | Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres |
| title_fullStr | Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres |
| title_full_unstemmed | Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres |
| title_short | Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres |
| title_sort | effect of process variables on the preparation of bsa loaded double-walled poly(lactide-co-glycolide) microspheres |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/52222/ http://irep.iium.edu.my/52222/2/participation%20Cert.%20scan.jpg http://irep.iium.edu.my/52222/13/52222.pdf |