A review on anticancer and biochemical properties of Clinacanthus nutans
Clinacanthus nutans (CN) (Belalai Gajah in Malay) is often used as herbal remedies complementary. The extracts from its dried leaves has been used traditionally to treat disease such as anti-venom for snake/insect bite. Phytochemical screening showed that the extract comprises of lupeol, –sitost...
| Main Authors: | , |
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
Kulliyah of Engineering, International Islamic University Malaysia
2016
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| Online Access: | http://irep.iium.edu.my/51801/ http://irep.iium.edu.my/51801/1/51801.pdf |
| _version_ | 1848783936752189440 |
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| author | Zakaria, Khairun Najwa Amid, Azura |
| author_facet | Zakaria, Khairun Najwa Amid, Azura |
| author_sort | Zakaria, Khairun Najwa |
| building | IIUM Repository |
| collection | Online Access |
| description | Clinacanthus nutans (CN) (Belalai Gajah in Malay) is often used as herbal remedies complementary. The
extracts from its dried leaves has been used traditionally to treat disease such as anti-venom for snake/insect
bite. Phytochemical screening showed that the extract comprises of lupeol, –sitosterol, stigmasterol, Botulin,
myricyl alcohol C-glycosyl flavones (vitexin, isovitexin, shaftoside, isomollupentin 7-O-b -glucopyranoside,
orientin and isoorientin), sulfur-containing glucosides, cerebrosides mixer, a monoacylmonogalactosylglycerol,
13-hydroxy-(13-S)-phaeophytin b, Pupurin-18-phytyl ester, phaeophorbide and
chlorophyll derivatives. Literature search showed that the ethanolic extract of CN had an antioxidant activity
and protective effect against free radical. Experimental evidences confirmed that the CN could be used in
treating tumor and cancer since it showed anticancer and antiproliferative properties. Its petroleum ether
extracts also demonstrated the strongest cytotoxic activity against HeLa and K-562 cells. The bioactive
compounds from CN are potential cytotoxic, antioxidant and antiproliferative properties against cultured
cancer cell lines, suggesting an alternate adjunctive regimen for cancer prevention or treatment. |
| first_indexed | 2025-11-14T16:29:16Z |
| format | Proceeding Paper |
| id | iium-51801 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:29:16Z |
| publishDate | 2016 |
| publisher | Kulliyah of Engineering, International Islamic University Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-518012017-01-13T02:40:17Z http://irep.iium.edu.my/51801/ A review on anticancer and biochemical properties of Clinacanthus nutans Zakaria, Khairun Najwa Amid, Azura RC254 Neoplasms. Tumors. Oncology (including Cancer) RS Pharmacy and materia medica Clinacanthus nutans (CN) (Belalai Gajah in Malay) is often used as herbal remedies complementary. The extracts from its dried leaves has been used traditionally to treat disease such as anti-venom for snake/insect bite. Phytochemical screening showed that the extract comprises of lupeol, –sitosterol, stigmasterol, Botulin, myricyl alcohol C-glycosyl flavones (vitexin, isovitexin, shaftoside, isomollupentin 7-O-b -glucopyranoside, orientin and isoorientin), sulfur-containing glucosides, cerebrosides mixer, a monoacylmonogalactosylglycerol, 13-hydroxy-(13-S)-phaeophytin b, Pupurin-18-phytyl ester, phaeophorbide and chlorophyll derivatives. Literature search showed that the ethanolic extract of CN had an antioxidant activity and protective effect against free radical. Experimental evidences confirmed that the CN could be used in treating tumor and cancer since it showed anticancer and antiproliferative properties. Its petroleum ether extracts also demonstrated the strongest cytotoxic activity against HeLa and K-562 cells. The bioactive compounds from CN are potential cytotoxic, antioxidant and antiproliferative properties against cultured cancer cell lines, suggesting an alternate adjunctive regimen for cancer prevention or treatment. Kulliyah of Engineering, International Islamic University Malaysia 2016 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/51801/1/51801.pdf Zakaria, Khairun Najwa and Amid, Azura (2016) A review on anticancer and biochemical properties of Clinacanthus nutans. In: 4th International Conference on Biotechnology Engineering 2016 (ICBioE 2016), 25th-27th July 2016, Kuala Lumpur. http://www.iium.edu.my/icbioe/2016/ |
| spellingShingle | RC254 Neoplasms. Tumors. Oncology (including Cancer) RS Pharmacy and materia medica Zakaria, Khairun Najwa Amid, Azura A review on anticancer and biochemical properties of Clinacanthus nutans |
| title | A review on anticancer and biochemical properties of Clinacanthus nutans |
| title_full | A review on anticancer and biochemical properties of Clinacanthus nutans |
| title_fullStr | A review on anticancer and biochemical properties of Clinacanthus nutans |
| title_full_unstemmed | A review on anticancer and biochemical properties of Clinacanthus nutans |
| title_short | A review on anticancer and biochemical properties of Clinacanthus nutans |
| title_sort | review on anticancer and biochemical properties of clinacanthus nutans |
| topic | RC254 Neoplasms. Tumors. Oncology (including Cancer) RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/51801/ http://irep.iium.edu.my/51801/ http://irep.iium.edu.my/51801/1/51801.pdf |