A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs
β-Carboline alkaloids present in Peganum harmala L. (harmal) have recently drawn attention due to their antitumor activities. Bovine Serum Albumin (BSA) is the major soluble protein constituent of the circulatory system, and has many physiological functions including the transportation of various...
| Main Authors: | , , , |
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
Kulliyah of Engineering, International Islamic University Malaysia
2016
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| Online Access: | http://irep.iium.edu.my/51789/ http://irep.iium.edu.my/51789/1/51789.pdf |
| _version_ | 1848783933534109696 |
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| author | Qadir, Anmbiya Khuroo, Mohammad Akbar Akbar, Iqrah Jamal, Parveen |
| author_facet | Qadir, Anmbiya Khuroo, Mohammad Akbar Akbar, Iqrah Jamal, Parveen |
| author_sort | Qadir, Anmbiya |
| building | IIUM Repository |
| collection | Online Access |
| description | β-Carboline alkaloids present in Peganum harmala L. (harmal) have recently drawn attention due to their
antitumor activities. Bovine Serum Albumin (BSA) is the major soluble protein constituent of the circulatory
system, and has many physiological functions including the transportation of various compounds as ligands.
In this study the binding of β-carboline alkaloids to Bovine Serum Albumin (BSA) has been investigated by
using a constant protein concentration and varying drug concentrations. The binding modes of β-carboline
alkaloids were analyzed by using FTIR and UV–Vis spectroscopic methods. Spectroscopic evidence showed
that β-carboline alkaloids bind BSA via hydrophobic interaction and Vander Waals contacts along with Hbonding
with the–NH groups. |
| first_indexed | 2025-11-14T16:29:13Z |
| format | Proceeding Paper |
| id | iium-51789 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:29:13Z |
| publishDate | 2016 |
| publisher | Kulliyah of Engineering, International Islamic University Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-517892017-10-19T13:37:35Z http://irep.iium.edu.my/51789/ A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs Qadir, Anmbiya Khuroo, Mohammad Akbar Akbar, Iqrah Jamal, Parveen QD Chemistry β-Carboline alkaloids present in Peganum harmala L. (harmal) have recently drawn attention due to their antitumor activities. Bovine Serum Albumin (BSA) is the major soluble protein constituent of the circulatory system, and has many physiological functions including the transportation of various compounds as ligands. In this study the binding of β-carboline alkaloids to Bovine Serum Albumin (BSA) has been investigated by using a constant protein concentration and varying drug concentrations. The binding modes of β-carboline alkaloids were analyzed by using FTIR and UV–Vis spectroscopic methods. Spectroscopic evidence showed that β-carboline alkaloids bind BSA via hydrophobic interaction and Vander Waals contacts along with Hbonding with the–NH groups. Kulliyah of Engineering, International Islamic University Malaysia 2016 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/51789/1/51789.pdf Qadir, Anmbiya and Khuroo, Mohammad Akbar and Akbar, Iqrah and Jamal, Parveen (2016) A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs. In: 4th International Conference on Biotechnology Engineering 2016 (ICBioE 2016), 25th-27th July 2016, Kuala Lumpur. http://www.iium.edu.my/icbioe/2016/ |
| spellingShingle | QD Chemistry Qadir, Anmbiya Khuroo, Mohammad Akbar Akbar, Iqrah Jamal, Parveen A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs |
| title | A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs |
| title_full | A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs |
| title_fullStr | A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs |
| title_full_unstemmed | A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs |
| title_short | A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs |
| title_sort | study of binding serum albumin proteins with β-carboline alkaloids :critical for pharmacological action of various drugs |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/51789/ http://irep.iium.edu.my/51789/ http://irep.iium.edu.my/51789/1/51789.pdf |