Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties

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Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties

Condensation of substituted anthranilic acids with 4-isothiocyanatoethyl-benzenesulfonamide led to series of heterocyclic benzenesulfonamides incorporating 2-mercapto-quinazolin-4-one tails. These sulfonamides were investigated as inhibitors of the human carbonic anhydrase (hCA, EC 4.2.1.1) isofor...

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Bibliographic Details
Main Authors:	Bozdag, Murat, Alafeefy, Ahmed Mahmoud, Carta, Fabrizio, Ceruso, Mariangela, Al-Tamimi, Abdul-Malek S., Al-Kahtani, Abdulla A., Alasmary, Fatmah A.S., Supuran, Claudiu T.
Format:	Article
Language:	English English English
Published:	Elsevier 2016
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/51705/ http://irep.iium.edu.my/51705/1/2016_4100-4107.pdf http://irep.iium.edu.my/51705/4/51705_benzenesulfonamides%20with%20subnanomolar%20carbonic_Scopus.pdf http://irep.iium.edu.my/51705/5/51705_benzenesulfonamides%20with%20subnanomolar%20carbonic_WoS.pdf

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