Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation
Microencapsulation is a promising approach in drug delivery to protect the drug from degradation and allow controlled release of the drug in the body. Fucoxanthin-loaded microsphere (F-LM) was fabricated by two step w/o/w double emulsion solvent evaporation method with poly (L-lactic-co-glycolic aci...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English English English |
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Japan Oil Chemists' Society
2016
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| Online Access: | http://irep.iium.edu.my/51371/ http://irep.iium.edu.my/51371/4/51371.pdf http://irep.iium.edu.my/51371/7/51371_Fabrication%20of%20fucoxanthin-loaded%20microsphere_Scopus.pdf http://irep.iium.edu.my/51371/8/51371_Fabrication%20of%20fucoxanthin-loaded%20microsphere_WoS.pdf |
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| author | Noviendri, Dedi Jaswir, Irwandi Bakhtiar, M. Taher Mohamed, Farahidah Mohd. Salleh, Hamzah Noorbatcha, Ibrahim Ali Octavianti, Fitri Lestari, Widya Hendri, Ridar Ahmad, Hasna Miyashita, Kazuo Abdullah, Alias |
| author_facet | Noviendri, Dedi Jaswir, Irwandi Bakhtiar, M. Taher Mohamed, Farahidah Mohd. Salleh, Hamzah Noorbatcha, Ibrahim Ali Octavianti, Fitri Lestari, Widya Hendri, Ridar Ahmad, Hasna Miyashita, Kazuo Abdullah, Alias |
| author_sort | Noviendri, Dedi |
| building | IIUM Repository |
| collection | Online Access |
| description | Microencapsulation is a promising approach in drug delivery to protect the drug from degradation and allow controlled release of the drug in the body. Fucoxanthin-loaded microsphere (F-LM) was fabricated by two step w/o/w double emulsion solvent evaporation method with poly (L-lactic-co-glycolic acid) (PLGA) as carrier. The effect of four types of surfactants (PVA, Tween-20, Span-20 and SDS), homogenization speed, and concentration of PLGA polymer and surfactant (PVA), respectively, on particle size and morphology of F-LM were investigated. Among the surfactants tested, PVA showed the best results with smallest particle size (9.18 µm) and a smooth spherical surface. Increasing the homogenization speed resulted in a smaller mean F-LM particle size [d(0.50)] from 17.12 to 9.18 µm. Best particle size results and good morphology were attained at homogenization speed of 20 500 rpm. Meanwhile, increased PLGA concentration from 1.5 to 11.0 (% w/v) resulted in increased F-LM particle size. The mean particle size [d(0.5)] of F-LM increased from 3.93 to 11.88 µm. At 6.0 (% w/v) PLGA, F-LM showed the best structure and external morphology. Finally, increasing PVA concentration from 0.5 to 3.5 (% w/v) resulted in decreased particle size from 9.18 to 4.86 µm. Fucoxanthin characterization before and after microencapsulation was carried out to assess the success of the microencapsulation procedure. Thermo gravimetry analysis (TGA), glass transition (Tg) temperature of F-LM and fucoxanthin measured using DSC, ATR-FTIR and XRD indicated that fucoxanthin was successfully encapsulated into the PLGA matrix, while maintaining the structural and chemical integrity of fucoxanthin. |
| first_indexed | 2025-11-14T16:27:45Z |
| format | Article |
| id | iium-51371 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T16:27:45Z |
| publishDate | 2016 |
| publisher | Japan Oil Chemists' Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-513712017-04-19T07:58:57Z http://irep.iium.edu.my/51371/ Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation Noviendri, Dedi Jaswir, Irwandi Bakhtiar, M. Taher Mohamed, Farahidah Mohd. Salleh, Hamzah Noorbatcha, Ibrahim Ali Octavianti, Fitri Lestari, Widya Hendri, Ridar Ahmad, Hasna Miyashita, Kazuo Abdullah, Alias RS Pharmacy and materia medica Microencapsulation is a promising approach in drug delivery to protect the drug from degradation and allow controlled release of the drug in the body. Fucoxanthin-loaded microsphere (F-LM) was fabricated by two step w/o/w double emulsion solvent evaporation method with poly (L-lactic-co-glycolic acid) (PLGA) as carrier. The effect of four types of surfactants (PVA, Tween-20, Span-20 and SDS), homogenization speed, and concentration of PLGA polymer and surfactant (PVA), respectively, on particle size and morphology of F-LM were investigated. Among the surfactants tested, PVA showed the best results with smallest particle size (9.18 µm) and a smooth spherical surface. Increasing the homogenization speed resulted in a smaller mean F-LM particle size [d(0.50)] from 17.12 to 9.18 µm. Best particle size results and good morphology were attained at homogenization speed of 20 500 rpm. Meanwhile, increased PLGA concentration from 1.5 to 11.0 (% w/v) resulted in increased F-LM particle size. The mean particle size [d(0.5)] of F-LM increased from 3.93 to 11.88 µm. At 6.0 (% w/v) PLGA, F-LM showed the best structure and external morphology. Finally, increasing PVA concentration from 0.5 to 3.5 (% w/v) resulted in decreased particle size from 9.18 to 4.86 µm. Fucoxanthin characterization before and after microencapsulation was carried out to assess the success of the microencapsulation procedure. Thermo gravimetry analysis (TGA), glass transition (Tg) temperature of F-LM and fucoxanthin measured using DSC, ATR-FTIR and XRD indicated that fucoxanthin was successfully encapsulated into the PLGA matrix, while maintaining the structural and chemical integrity of fucoxanthin. Japan Oil Chemists' Society 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/51371/4/51371.pdf application/pdf en http://irep.iium.edu.my/51371/7/51371_Fabrication%20of%20fucoxanthin-loaded%20microsphere_Scopus.pdf application/pdf en http://irep.iium.edu.my/51371/8/51371_Fabrication%20of%20fucoxanthin-loaded%20microsphere_WoS.pdf Noviendri, Dedi and Jaswir, Irwandi and Bakhtiar, M. Taher and Mohamed, Farahidah and Mohd. Salleh, Hamzah and Noorbatcha, Ibrahim Ali and Octavianti, Fitri and Lestari, Widya and Hendri, Ridar and Ahmad, Hasna and Miyashita, Kazuo and Abdullah, Alias (2016) Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation. Journal of Oleo Science, 65 (8). pp. 641-653. ISSN 1347-3352 E-ISSN 1345-8957 https://www.jstage.jst.go.jp/article/jos/65/8/65_ess16018/_pdf 10.5650/jos.ess 16018 |
| spellingShingle | RS Pharmacy and materia medica Noviendri, Dedi Jaswir, Irwandi Bakhtiar, M. Taher Mohamed, Farahidah Mohd. Salleh, Hamzah Noorbatcha, Ibrahim Ali Octavianti, Fitri Lestari, Widya Hendri, Ridar Ahmad, Hasna Miyashita, Kazuo Abdullah, Alias Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation |
| title | Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation |
| title_full | Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation |
| title_fullStr | Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation |
| title_full_unstemmed | Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation |
| title_short | Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation |
| title_sort | fabrication of fucoxanthin-loaded microsphere ( f-lm) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/51371/ http://irep.iium.edu.my/51371/ http://irep.iium.edu.my/51371/ http://irep.iium.edu.my/51371/4/51371.pdf http://irep.iium.edu.my/51371/7/51371_Fabrication%20of%20fucoxanthin-loaded%20microsphere_Scopus.pdf http://irep.iium.edu.my/51371/8/51371_Fabrication%20of%20fucoxanthin-loaded%20microsphere_WoS.pdf |