Label-free microfluidic blood cells micro-separator
Blood cells separation is of great interest in many biomedical applications because of its importance in sample preparation for both clinical diagnosis and therapeutic research. In this work, the micro-separator uses the combination of magnetophoresis with hydrodynamics in order to separate whit...
| Main Authors: | , |
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| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
IEEE
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/51267/ http://irep.iium.edu.my/51267/5/51267-new.pdf http://irep.iium.edu.my/51267/8/51267_label%20free%20microfluidic_scopus.pdf |
| _version_ | 1848783820536414208 |
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| author | Aissa, Foughalia Ibrahim, Siti Noorjannah |
| author_facet | Aissa, Foughalia Ibrahim, Siti Noorjannah |
| author_sort | Aissa, Foughalia |
| building | IIUM Repository |
| collection | Online Access |
| description | Blood cells separation is of great interest in many
biomedical applications because of its importance in sample
preparation for both clinical diagnosis and therapeutic research.
In this work, the micro-separator uses the combination of
magnetophoresis with hydrodynamics in order to separate white
blood cells (WBCs) and red blood cells (RBCs) by taking into
account the magnetization of the ferromagnetic elements and
fluidic forces on the cells. The microfluidic devices can achieve
label-free, continuous separation of WBCs and RBCs with
relatively high efficiency. The micro-separator utilizes
hydrodynamic force acting on cells within laminar flow, coupled
with magnetophoresis force in novel U-shaped micro-channel.
Here, we report the separation efficiency of the microfluidic
device in continuous flow based on results of a 3D model
simulation conducted in COMSOL Multiphysics. The proposed
device enables label-free cell separation and thus, it can be a
useful microfluidic component for lab-on-a-chip system and
integrated biological and biomedical applications. |
| first_indexed | 2025-11-14T16:27:26Z |
| format | Proceeding Paper |
| id | iium-51267 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:27:26Z |
| publishDate | 2016 |
| publisher | IEEE |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-512672017-01-10T03:19:24Z http://irep.iium.edu.my/51267/ Label-free microfluidic blood cells micro-separator Aissa, Foughalia Ibrahim, Siti Noorjannah TK452 Electric apparatus and materials. Electric circuits. Electric networks TK7885 Computer engineering Blood cells separation is of great interest in many biomedical applications because of its importance in sample preparation for both clinical diagnosis and therapeutic research. In this work, the micro-separator uses the combination of magnetophoresis with hydrodynamics in order to separate white blood cells (WBCs) and red blood cells (RBCs) by taking into account the magnetization of the ferromagnetic elements and fluidic forces on the cells. The microfluidic devices can achieve label-free, continuous separation of WBCs and RBCs with relatively high efficiency. The micro-separator utilizes hydrodynamic force acting on cells within laminar flow, coupled with magnetophoresis force in novel U-shaped micro-channel. Here, we report the separation efficiency of the microfluidic device in continuous flow based on results of a 3D model simulation conducted in COMSOL Multiphysics. The proposed device enables label-free cell separation and thus, it can be a useful microfluidic component for lab-on-a-chip system and integrated biological and biomedical applications. IEEE 2016-05 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/51267/5/51267-new.pdf application/pdf en http://irep.iium.edu.my/51267/8/51267_label%20free%20microfluidic_scopus.pdf Aissa, Foughalia and Ibrahim, Siti Noorjannah (2016) Label-free microfluidic blood cells micro-separator. In: 2016 Symposium on Design, Test, Integration and Packaging of MEMS/MOEMS (DTIP), 30th May-2nd June 2016, Budapest, Hungary. http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=7514861&filter%3DAND%28p_IS_Number%3A7514818%29%26rowsPerPage%3D75 10.1109/DTIP.2016.7514861 |
| spellingShingle | TK452 Electric apparatus and materials. Electric circuits. Electric networks TK7885 Computer engineering Aissa, Foughalia Ibrahim, Siti Noorjannah Label-free microfluidic blood cells micro-separator |
| title | Label-free microfluidic blood cells micro-separator |
| title_full | Label-free microfluidic blood cells micro-separator |
| title_fullStr | Label-free microfluidic blood cells micro-separator |
| title_full_unstemmed | Label-free microfluidic blood cells micro-separator |
| title_short | Label-free microfluidic blood cells micro-separator |
| title_sort | label-free microfluidic blood cells micro-separator |
| topic | TK452 Electric apparatus and materials. Electric circuits. Electric networks TK7885 Computer engineering |
| url | http://irep.iium.edu.my/51267/ http://irep.iium.edu.my/51267/ http://irep.iium.edu.my/51267/ http://irep.iium.edu.my/51267/5/51267-new.pdf http://irep.iium.edu.my/51267/8/51267_label%20free%20microfluidic_scopus.pdf |