Ectopic miRNA network and the crosstalk between different signalling pathways during EMT and MET
The tumor microenvironment (TEM) comprise of various cellular and molecular components such as fibroblasts, immune cells, bone marrow-derived inflammatory cells, endothelial cells, extracellular matrix (ECM), and signaling molecules. The complex crosstalk between (TEM) components and malignant cells...
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| Format: | Proceeding Paper |
| Language: | English |
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Kulliyyah of Engineering, International Islamic University Malaysia
2016
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| Online Access: | http://irep.iium.edu.my/51251/ http://irep.iium.edu.my/51251/1/51251_Ectopic_miRNA_network.pdf |
| _version_ | 1848783817191456768 |
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| author | Razak, Eliza Yusof, Faridah Ahmad Raus, Raha |
| author_facet | Razak, Eliza Yusof, Faridah Ahmad Raus, Raha |
| author_sort | Razak, Eliza |
| building | IIUM Repository |
| collection | Online Access |
| description | The tumor microenvironment (TEM) comprise of various cellular and molecular components such as fibroblasts, immune cells, bone marrow-derived inflammatory cells, endothelial cells, extracellular matrix (ECM), and signaling molecules. The complex crosstalk between (TEM) components and malignant cells can give rise to tumorigenesis, progression, and angiogenesis as well as micro-metastasis and macro-metastasis. MicroRNAs (miRNAs) are small, non-coding extracellular RNAs involved in post-transcriptional regulation of gene silencing or degradation by base paring at open reading frame (ORF) region of the target mRNA. Recent advances in the miRNA field have driven to the understanding of multiple regulatory aspects concerning cancer biology. Aberrant miRNA expression in malignant tumors compared with normal tissue are promising biomarkers for cancer diagnosis. Epithelial-to-mesenchymal transition (EMT) is a reversible process in which neoplastic epithelial cells expressed mesenchymal phenotypes and resulting in alteration of cell autonomous mechanisms. EMT enables epithelial cells to lose their cell polarity, acquire cancer stem cell-like properties which favor tumor invasion, extravasation and metastasis. Mesenchymal–epithelial transition (MET) is the inverse process of EMT. This results in stabilization of distant metastases by permitting cancerous cells to recoup epithelial phenotypes and integrate into distant organs. Ectopic microRNA expression and disturbed signaling pathways have been associated with EMT and MET processes. This review describes the co-regulatory loops among miRNAs, target genes and important regulatory pathways involved in cancer. |
| first_indexed | 2025-11-14T16:27:22Z |
| format | Proceeding Paper |
| id | iium-51251 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:27:22Z |
| publishDate | 2016 |
| publisher | Kulliyyah of Engineering, International Islamic University Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-512512017-01-13T08:24:05Z http://irep.iium.edu.my/51251/ Ectopic miRNA network and the crosstalk between different signalling pathways during EMT and MET Razak, Eliza Yusof, Faridah Ahmad Raus, Raha TP248.13 Biotechnology The tumor microenvironment (TEM) comprise of various cellular and molecular components such as fibroblasts, immune cells, bone marrow-derived inflammatory cells, endothelial cells, extracellular matrix (ECM), and signaling molecules. The complex crosstalk between (TEM) components and malignant cells can give rise to tumorigenesis, progression, and angiogenesis as well as micro-metastasis and macro-metastasis. MicroRNAs (miRNAs) are small, non-coding extracellular RNAs involved in post-transcriptional regulation of gene silencing or degradation by base paring at open reading frame (ORF) region of the target mRNA. Recent advances in the miRNA field have driven to the understanding of multiple regulatory aspects concerning cancer biology. Aberrant miRNA expression in malignant tumors compared with normal tissue are promising biomarkers for cancer diagnosis. Epithelial-to-mesenchymal transition (EMT) is a reversible process in which neoplastic epithelial cells expressed mesenchymal phenotypes and resulting in alteration of cell autonomous mechanisms. EMT enables epithelial cells to lose their cell polarity, acquire cancer stem cell-like properties which favor tumor invasion, extravasation and metastasis. Mesenchymal–epithelial transition (MET) is the inverse process of EMT. This results in stabilization of distant metastases by permitting cancerous cells to recoup epithelial phenotypes and integrate into distant organs. Ectopic microRNA expression and disturbed signaling pathways have been associated with EMT and MET processes. This review describes the co-regulatory loops among miRNAs, target genes and important regulatory pathways involved in cancer. Kulliyyah of Engineering, International Islamic University Malaysia 2016 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/51251/1/51251_Ectopic_miRNA_network.pdf Razak, Eliza and Yusof, Faridah and Ahmad Raus, Raha (2016) Ectopic miRNA network and the crosstalk between different signalling pathways during EMT and MET. In: 4th International Conference on Biotechnology Engineering 2016 (ICBioE 2016), 25th-27th July 2016, Kuala Lumpur. http://iiumpress.iium.edu.my/bookshop/orthodontics-and-you |
| spellingShingle | TP248.13 Biotechnology Razak, Eliza Yusof, Faridah Ahmad Raus, Raha Ectopic miRNA network and the crosstalk between different signalling pathways during EMT and MET |
| title | Ectopic miRNA network and the crosstalk between different signalling pathways during EMT and MET |
| title_full | Ectopic miRNA network and the crosstalk between different signalling pathways during EMT and MET |
| title_fullStr | Ectopic miRNA network and the crosstalk between different signalling pathways during EMT and MET |
| title_full_unstemmed | Ectopic miRNA network and the crosstalk between different signalling pathways during EMT and MET |
| title_short | Ectopic miRNA network and the crosstalk between different signalling pathways during EMT and MET |
| title_sort | ectopic mirna network and the crosstalk between different signalling pathways during emt and met |
| topic | TP248.13 Biotechnology |
| url | http://irep.iium.edu.my/51251/ http://irep.iium.edu.my/51251/ http://irep.iium.edu.my/51251/1/51251_Ectopic_miRNA_network.pdf |